Inflammatory Biomarkers in Type 1 Diabetes

Type 1 Diabetes (T1D) is a severe autoimmune disorder marked by the immune system's targeted destruction of pancreatic beta cells, leading to a critical reduction in insulin production and resultant systemic hyperglycemia. As T1D diagnoses climb globally, especially among children, the necessity for reliable biomarkers that indicate early, pre-symptomatic stages of the disease becomes ever more crucial. The inflammatory process, despite being well-known, remains inadequately understood, particularly in how it could serve as an indicator for the onset of T1D.
Notably, cytokines such as Interleukin-1β (IL-1β), Tumor Necrosis Factor-α (TNF-α), and Interferon-γ (IFN-γ) have been associated with inflammation but fall short of facilitating early identification of the disease.
The current urgency lies in developing biomarkers capable of detecting early inflammatory processes linked with T1D, which can provide insights into potential preventive or delaying strategies for the disease and its adverse effects.

Current research into microRNAs (miRNAs) presents a promising direction, as they offer potential as biomarkers capable of identifying early T1D stages. Capitalizing on these advancements could also reveal new targets for therapy, establishing a robust framework for diagnosing and managing T1D efficiently.

This Research Topic aims to encapsulate the current understanding of inflammation-associated markers in T1D patients, focusing on enhancing the diagnostics and therapy. Emphasis will be placed on identifying and understanding novel and existing inflammatory markers and potential therapeutic opportunities they present. To gather further insights, we welcome articles addressing, but not limited to, the following themes:

• Overview of inflammation in T1D and its role in disease onset and progression.
• Discovery and analysis of novel key inflammatory markers, especially miRNAs.
• Unveiling the mechanisms of inflammation driven by these markers.
• Clinical perspectives on diagnostic feasibility and application of inflammation markers in T1D.
• Complications arising from systemic inflammation including cardiovascular, skeletal, and kidney issues.
• Emerging research, recent study reviews, and suggestions for future studies’ directions.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Type 1 diabetes, hyperglycaemia, biomarkers, miRNAs, cytokines, systemic inflammation, T1D complications

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.