Mesenchymal Stem Cells and Derived Extracellular Vesicles as Next-Generation Biological Drugs for Tissue Regeneration

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ORIGINAL RESEARCH

Published on 12 Nov 2025

Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats

Barbara Porto Cipriano
Rachel Santana Cunha
Thaís Alves de Santana
Kátia Nunes da Silva
Erick Correia Loiola
Júlio César Queiroz Figueiredo
Elisama Araújo da Silva
Adne Vitória Rocha de Lima
Erik Aranha Rossi
4 more
Bruno Solano de Freitas Souza

doi 10.3389/fphar.2025.1695914

REVIEW

Accepted on 10 Nov 2025

Endoplasmic Reticulum Stress and Exosomes Secretion in the Pathogenesis of Inflammatory Bowel Disease: A Concise Summary of Research Findings

Ashiq Shibili P
Antara Banerjee
Soham Chakraborty
Suresh Babu Kondaveeti
Andrea Porzionato
Silvia Barbon
Surajit Pathak

REVIEW

Published on 25 Sep 2025

Adipose-derived stem cell exosomes: emerging roles and therapeutic application

Yuhan Gong
Hui Ma
Zhongren Zheng
Xinjie Wang
Jiahua Zhang
Xiaowei Zhao

doi 10.3389/fphar.2025.1637342

3,120 views

ORIGINAL RESEARCH

Published on 15 Sep 2025

Modulation of ASC-derived extracellular vesicles containing cargo that specifically enhances wound healing

Jodi P. Gurney
John W. Ludlow
Michael J. Van Kanegan
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doi 10.3389/fphar.2025.1635151

1,399 views
1 citation

REVIEW

Published on 12 Sep 2025

Mesenchymal stromal cell-laden hydrogels in tissue regeneration: insights from preclinical and clinical research

Silvia Barbon
Senthilkumar Rajendran
Antara Banerjee
Pier Paolo Parnigotto
Raffaele De Caro
Veronica Macchi
Andrea Porzionato

doi 10.3389/fphar.2025.1670649

2,799 views

REVIEW

Published on 19 Aug 2025

The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases

Mateusz Matwiejuk
Agnieszka Mikłosz
Hanna Myśliwiec
Adrian Chabowski
Iwona Flisiak

doi 10.3389/fimmu.2025.1626066

2,915 views

REVIEW

Published on 17 Jul 2025

From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment

Hailian Ye
Qi He
Fang Qi
Guangchao Xu
Mulan Qahar
Chenliang Deng
Zairong Wei

doi 10.3389/fimmu.2025.1609288

1,793 views
1 citation

REVIEW

Published on 03 Jun 2025

A bibliometric analysis of research trends in mesenchymal stem cell therapy for neonatal bronchopulmonary dysplasia: 2004–2024

Lu Bai
Yue Xin

doi 10.3389/fped.2025.1558301

2,184 views
1 citation

ORIGINAL RESEARCH

Published on 13 Mar 2025

A bibliometric and visualized analysis of extracellular vesicles in degenerative musculoskeletal diseases (from 2006 to 2024)

Jun-Jie Yang
Sha-Qi He
Bei Huang
Peng-Xin Wang
Feng Xu
Xiao Lin
Jun Liu

doi 10.3389/fphar.2025.1550208

1,947 views

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Frontiers in Pharmacology

Integrative and Regenerative Pharmacology

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Articles

Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats

Endoplasmic Reticulum Stress and Exosomes Secretion in the Pathogenesis of Inflammatory Bowel Disease: A Concise Summary of Research Findings

Adipose-derived stem cell exosomes: emerging roles and therapeutic application

Modulation of ASC-derived extracellular vesicles containing cargo that specifically enhances wound healing

Mesenchymal stromal cell-laden hydrogels in tissue regeneration: insights from preclinical and clinical research

The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases

From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment

A bibliometric analysis of research trends in mesenchymal stem cell therapy for neonatal bronchopulmonary dysplasia: 2004–2024

A bibliometric and visualized analysis of extracellular vesicles in degenerative musculoskeletal diseases (from 2006 to 2024)

Frontiers in Pharmacology

Integrative and Regenerative Pharmacology