Reactive Oxygen Species (ROS) in Nanomedicine: Innovations, Challenges, and Future Directions

Nanomedicine has recently recognized the dual role of Reactive Oxygen Species (ROS) in health and disease, promoting significant interest in exploring their therapeutic potentials and pathological implications. Originally implicated in contributing to a myriad of diseases due to their excessive levels, ROS also play beneficial roles in cellular processes related to growth, fitness, and aging. Consequently, their unique biochemical properties are being harnessed to innovate medical treatments, particularly in addressing chronic inflammation, aging, and cancer through antitumor strategies.

This Research Topic aims to serve as a proactive platform for interdisciplinary investigation into the complexities of ROS within the field of nanomedicine. Its goal is to enhance our understanding of ROS mechanisms in disease and therapy, develop innovative therapeutic strategies utilizing ROS, and address the challenges in their application and management. By bringing together insights from nanomedicine, biochemistry, and materials science, this special issue seeks to forge new pathways in the use of ROS to improve health outcomes.

To gather further insights into the interactions between ROS and nanomedicine, we welcome articles addressing, but not limited to, the following themes:

Mechanisms of ROS Generation and Scavenging by Nanoparticles:

Studies on how various nanoparticles induce ROS and their underlying mechanisms.

Investigations into nanoparticle-based ROS scavenging strategies and their implications for disease treatment.

Antioxidant Nanomedicines: Design, Efficacy, and Applications:

Developments in antioxidant nanoparticle designs and their applications in chronic diseases and aging.

Evaluations of the safety and effectiveness of these nanoparticles in clinical and preclinical studies.

Targeted Delivery and Controlled Release of ROS-Related Therapies:

Enhancements in targeted delivery systems for ROS-oriented nanoparticles.

Advances in controlled release systems that regulate ROS therapeutic levels in response to bodily signals.

Challenges and Future Directions in ROS-Nanomedicine Research:

Discussion of current limitations such as toxicity and biocompatibility.

Proposals for future research avenues and technological breakthroughs in ROS applications.