Systemic Sclerosis: Immunological Impacts

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ORIGINAL RESEARCH

Published on 02 Dec 2025

Serum profiling of uPA, PAI-1, and suPAR in systemic sclerosis: a preliminary study on analytical aspects and associations with microvascular and fibrotic manifestations

Filomena Napolitano
Ilaria Mormile
Gabriele Mignogna
Amato de Paulis
Francesca Wanda Rossi
Nunzia Montuori

doi 10.3389/fimmu.2025.1697785

1,196 views

MINI REVIEW

Published on 24 Oct 2025

The clinical utility of autoantibodies in systemic sclerosis: a review with a focus on cohort differences and standardization

Kazuhiro Komura

doi 10.3389/fimmu.2025.1691988

2,225 views

ORIGINAL RESEARCH

Published on 16 Oct 2025

A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects

A Ram Lee
Su Been Jeon
Hye Won Kwak
Suh Won Yang
Yoo Jin Bang
Seon-Yeong Lee
So Won Lee
Jin Hyung Park
Se Gyeong Han
3 more
Jae-Hwan Nam

doi 10.3389/fimmu.2025.1665998

2,421 views

ORIGINAL RESEARCH

Published on 05 Sep 2025

Identification of crosstalk genes and diagnostic biomarkers in systemic sclerosis associated sarcopenia through integrative analysis and machine learning

Yanfang Wu
Yunfeng Dai
Fei Gao
Haiping Xie
Shuyao Pan
Juanjuan He
Jianwen Liu
He Lin
Zhihan Chen
Junping Wen

doi 10.3389/fimmu.2025.1642806

2,212 views
1 citation

CASE REPORT

Published on 03 Jul 2025

Tocilizumab combined with cyclophosphamide for the treatment of rapidly progressive refractory systemic sclerosis with predominant cardiac involvement: a case report

Zhong-Chao Fu
Jing Ji
Xiao-Gui Cheng
Ran-Geng Shi
Xiao-Feng Mo
Zhi-Zhu Yang

doi 10.3389/fimmu.2025.1614714

2,065 views
2 citations

REVIEW

Published on 16 Apr 2025

A review of recent studies on the pathogenesis of Systemic Sclerosis: focus on fibrosis pathways

Sergio A. Jimenez
Fabian A. Mendoza
Sonsoles Piera-Velazquez

doi 10.3389/fimmu.2025.1551911

7,241 views
14 citations

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Frontiers in Immunology

Cytokines and Soluble Mediators in Immunity

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