The Insights of Multi-Omics into the Microenvironment After Tumor Metastasis: A Paradigm Shift in Molecular Targeting Modeling and Immunotherapy for Advanced Cancer Patients

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Articles

ORIGINAL RESEARCH

Accepted on 29 Aug 2025

Integrating Deep Learning Features from Mammography with SHAP Values for a Machine Learning Model Predicting Over 5-Year Recurrence of Breast Ductal Carcinoma In Situ Post-Lumpectomy

Yupeng Sha
Yuan Quan
Yi Du
Shuqi Yang
Ming Niu
Xiaoshuan Liang
Shanshan Sun
Tong Li
Shu Gong
Jiguang Han

doi 10.3389/fimmu.2025.1681072

ORIGINAL RESEARCH

Accepted on 29 Aug 2025

Stemness-and Hypoxia-Based Prognostic Stratification Index Reveals G6PD as a Regulator of Hypoxia-Driven Stemness in Hepatocellular Carcinoma

Mingwei Gao
Yuechuan Liu
Jianhui Wu
Peiru Zhang
Jin Liu
Kun Guo
Binwen Sun
Sunbin Ling
Liming Wang

doi 10.3389/fimmu.2025.1669275

REVIEW

Accepted on 28 Aug 2025

Integrating Single-Cell Omics and Materials Science for Uveal Melanoma: From Mechanistic Insights to Precision Therapeutics

Shouyong Fu
Changfei Li

doi 10.3389/fonc.2025.1661889

117 views

REVIEW

Accepted on 22 Aug 2025

Multi-Omics Analysis of the Tumor Microenvironment After Metastasis: Advancing Toward Personalized Immunotherapy and Molecular Targeted Strategies

Dongmei Quan
Huqiang Wu
Li Duan
Guanhua Lv
Qing Gao

doi 10.3389/fimmu.2025.1648987

131 views

ORIGINAL RESEARCH

Accepted on 20 Aug 2025

AI-Based Non-invasive Profiling of the Tumor Immune Microenvironment Using Longitudinal CT Radiomics Predicts Immunotherapy Response in Lung Cancer

Guangjie Liu
Xiaoyan Zhang
Yutong He
Di Liang
Shaonan Xie
Ning Zhang
Nan Geng
Liwen Zhang
Yajie Huang
1 more
Qingyi Liu

doi 10.3389/fimmu.2025.1664726

130 views

ORIGINAL RESEARCH

Published on 20 Aug 2025

Diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma

Yicheng Wen
Xin Yi
Jixin Shi
Peng Wan
Huan Wang
Li Tian
Huixia Liu

doi 10.3389/fimmu.2025.1662638

562 views

ORIGINAL RESEARCH

Published on 13 Aug 2025

Analysis of standard vs dose-escalated stereotactic body radiation therapy in localized prostate cancer: a comparative evaluation of survival outcomes

Bichun Xu
Xianzhi Zhao
Tingting Wei
Yiyin Liang
Weiwei Zhang
Liang Chen
Zuping Lian
Huojun Zhang

doi 10.3389/fimmu.2025.1654174

834 views

CORRECTION

Published on 05 Aug 2025

Correction: The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study

Frontiers Production Office

doi 10.3389/fimmu.2025.1671178

557 views

REVIEW

Published on 05 Aug 2025

Targeting GABA signaling in the tumor microenvironment: implications for immune cell regulation and immunotherapy resistance

Yuanqing Zhao
Jin Xu
Ke Yang
Li Bao

doi 10.3389/fimmu.2025.1645718

922 views

ORIGINAL RESEARCH

Published on 21 Jul 2025

Integrating proteomics and machine learning reveals characteristics and risks of lymph node-independent distant metastasis in colorectal cancer

Chenxiao Zheng
Baiwang Zhu
Yanyu Chen
Numan Shahid
Yiwang Hu
Hajar Mansoor Ahmed Ali Husain
Binbin Ou
Qiongying Zhang
Haobo Jin
3 more
Xiaodong Zhang

doi 10.3389/fimmu.2025.1622528

1,639 views

ORIGINAL RESEARCH

Published on 16 Jul 2025

The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study

Yao Wang
Du Meilu
Shi Qi
Tang Yufei
Gao Song
Han Susu
Wen Haotian
Zhu Tingting
Wang Chao
1 more
Yin Xiaoling

doi 10.3389/fimmu.2025.1582308

1,361 views

ORIGINAL RESEARCH

Published on 03 Jul 2025

Analysis of immune cell infiltration in the tumor microenvironment of cervical cancer and its impact on immunotherapy

Fei Qin
Lu Huan
Xia Shi
Yuanyuan Hua
Yi Wu

doi 10.3389/fonc.2025.1608597

1,222 views

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Frontiers in Oncology

Cancer Immunity and Immunotherapy
Gynecological Oncology

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Frontiers in Immunology
- Cancer Immunity and Immunotherapy
- 5.9 impact factor
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Articles

Integrating Deep Learning Features from Mammography with SHAP Values for a Machine Learning Model Predicting Over 5-Year Recurrence of Breast Ductal Carcinoma In Situ Post-Lumpectomy

Stemness-and Hypoxia-Based Prognostic Stratification Index Reveals G6PD as a Regulator of Hypoxia-Driven Stemness in Hepatocellular Carcinoma

Integrating Single-Cell Omics and Materials Science for Uveal Melanoma: From Mechanistic Insights to Precision Therapeutics

Multi-Omics Analysis of the Tumor Microenvironment After Metastasis: Advancing Toward Personalized Immunotherapy and Molecular Targeted Strategies

AI-Based Non-invasive Profiling of the Tumor Immune Microenvironment Using Longitudinal CT Radiomics Predicts Immunotherapy Response in Lung Cancer

Diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma

Analysis of standard vs dose-escalated stereotactic body radiation therapy in localized prostate cancer: a comparative evaluation of survival outcomes

Correction: The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study

Targeting GABA signaling in the tumor microenvironment: implications for immune cell regulation and immunotherapy resistance

Integrating proteomics and machine learning reveals characteristics and risks of lymph node-independent distant metastasis in colorectal cancer

The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study

Analysis of immune cell infiltration in the tumor microenvironment of cervical cancer and its impact on immunotherapy

Frontiers in Oncology

Cancer Immunity and Immunotherapy

Gynecological Oncology

Participating Journals

Frontiers in Immunology

Cancer Immunity and Immunotherapy