The Insights of Multi-Omics into the Microenvironment After Tumor Metastasis: A Paradigm Shift in Molecular Targeting Modeling and Immunotherapy for Advanced Cancer Patients

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EDITORIAL

Published on 16 Dec 2025

Editorial: The insights of multi-omics into the microenvironment after tumor metastasis: a paradigm shift in molecular targeting modeling and immunotherapy for advanced cancer patients

Xuejian Liu
Qi Wang
Yang Ma
Xinhua Xiao
Xue Zhao
Hailin Tang
Divya Gopinath
Chao Wang

doi 10.3389/fonc.2025.1749178

197 views

MINI REVIEW

Published on 03 Nov 2025

Antibody-drug conjugates as immuno-oncology agents in colorectal cancer: targets, payloads, and therapeutic synergies

Yihan Wang
Kai Lu
Yang Xu
Shengshan Xu
Hongyu Chu
Xuedong Fang

doi 10.3389/fimmu.2025.1678907

3,080 views
1 citation

ORIGINAL RESEARCH

Published on 01 Oct 2025

AI-based non-invasive profiling of the tumor immune microenvironment using longitudinal CT radiomics predicts immunotherapy response in lung cancer

Guangjie Liu
Xiaoyan Zhang
Yutong He
Di Liang
Shaonan Xie
Ning Zhang
Nan Geng
Liwen Zhang
Yajie Huang
1 more
Qingyi Liu

doi 10.3389/fimmu.2025.1664726

1,624 views

ORIGINAL RESEARCH

Published on 01 Oct 2025

Targeting the CCL28-STAT3-PLAC8 axis to suppress metastasis and remodel tumor microenvironment in colorectal cancer

Yao Yang
Qixin Jiang
Zhe Zhu
Shun Zhang
Tao Du
Shuzheng Song
Xiaohua Jiang

doi 10.3389/fimmu.2025.1610540

1,401 views

ORIGINAL RESEARCH

Published on 01 Oct 2025

Development and validation of a novel sodium-overload related genes signature for prognostic prediction in breast cancer: integrating bioinformatics and experimental approaches

Qizhen Feng
Wenlin Yang
Guohao Su
Fei Wu
Chungen Xing

doi 10.3389/fimmu.2025.1653903

2,072 views

REVIEW

Published on 23 Sep 2025

Multi-omics analysis of the tumor microenvironment after metastasis: advancing toward personalized immunotherapy and molecular targeted strategies

Qing Gao
Huqiang Wu
Li Duan
Guanhua Lv
Dongmei Quan

doi 10.3389/fimmu.2025.1648987

2,160 views

ORIGINAL RESEARCH

Published on 19 Sep 2025

Stemness- and hypoxia-based prognostic stratification index reveals G6PD as a regulator of hypoxia-driven stemness in hepatocellular carcinoma

Mingwei Gao
Yuechuan Liu
Jianhui Wu
Peiru Zhang
Jin Liu
Kun Guo
Binwen Sun
Sunbin Ling
Liming Wang

doi 10.3389/fimmu.2025.1669275

1,733 views

ORIGINAL RESEARCH

Published on 15 Sep 2025

Integrating deep learning features from mammography with SHAP values for a machine learning model predicting over 5-year recurrence of breast ductal carcinoma In Situ post-lumpectomy

Yupeng Sha
Quan Yuan
Yi Du
Shuqi Yang
Ming Niu
Xiaoshuan Liang
Shanshan Sun
Tong Li
Shu Gong
Jiguang Han

doi 10.3389/fimmu.2025.1681072

1,727 views

REVIEW

Published on 10 Sep 2025

Integrating single-cell omics and materials science for uveal melanoma: from mechanistic insights to precision therapeutics

Shouyong Fu
Changfei Li

doi 10.3389/fonc.2025.1661889

2,042 views

ORIGINAL RESEARCH

Published on 20 Aug 2025

Diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma

Yicheng Wen
Xin Yi
Jixin Shi
Peng Wan
Huan Wang
Li Tian
Huixia Liu

doi 10.3389/fimmu.2025.1662638

2,121 views

ORIGINAL RESEARCH

Published on 13 Aug 2025

Analysis of standard vs dose-escalated stereotactic body radiation therapy in localized prostate cancer: a comparative evaluation of survival outcomes

Bichun Xu
Xianzhi Zhao
Tingting Wei
Yiyin Liang
Weiwei Zhang
Liang Chen
Zuping Lian
Huojun Zhang

doi 10.3389/fimmu.2025.1654174

1,764 views

CORRECTION

Published on 05 Aug 2025

Correction: The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study

Frontiers Production Office

doi 10.3389/fimmu.2025.1671178

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Articles

Editorial: The insights of multi-omics into the microenvironment after tumor metastasis: a paradigm shift in molecular targeting modeling and immunotherapy for advanced cancer patients

Antibody-drug conjugates as immuno-oncology agents in colorectal cancer: targets, payloads, and therapeutic synergies

AI-based non-invasive profiling of the tumor immune microenvironment using longitudinal CT radiomics predicts immunotherapy response in lung cancer

Targeting the CCL28-STAT3-PLAC8 axis to suppress metastasis and remodel tumor microenvironment in colorectal cancer

Development and validation of a novel sodium-overload related genes signature for prognostic prediction in breast cancer: integrating bioinformatics and experimental approaches

Multi-omics analysis of the tumor microenvironment after metastasis: advancing toward personalized immunotherapy and molecular targeted strategies

Stemness- and hypoxia-based prognostic stratification index reveals G6PD as a regulator of hypoxia-driven stemness in hepatocellular carcinoma

Integrating deep learning features from mammography with SHAP values for a machine learning model predicting over 5-year recurrence of breast ductal carcinoma In Situ post-lumpectomy

Integrating single-cell omics and materials science for uveal melanoma: from mechanistic insights to precision therapeutics

Diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma

Analysis of standard vs dose-escalated stereotactic body radiation therapy in localized prostate cancer: a comparative evaluation of survival outcomes

Correction: The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study

Frontiers in Oncology

Cancer Immunity and Immunotherapy

Gynecological Oncology

Other participating journals

Frontiers in Immunology

Cancer Immunity and Immunotherapy