Advancing Pulmonary Therapeutics with Novel Drug Delivery Technologies

Pulmonary drug delivery represents a rapidly evolving field that holds significant promise for treating respiratory and systemic ailments. The allure of this route stems from its capability to target localized areas, its rapid therapeutic effects, and reduced systemic side effects. Nevertheless, several challenges persist, such as optimizing particle deposition, ensuring drug stability, and overcoming biological barriers in the lungs. Advanced drug delivery systems like nanoparticles, microparticles, and lipid-based carriers are revolutionizing this domain by enabling controlled release, enhancing bioavailability, and achieving precise targeting of therapeutic agents within the respiratory system.

This Research Topic aims to tackle critical challenges and showcase innovative strategies to advance pulmonary drug delivery systems. The topic will delve into the effectiveness of advanced drug delivery platforms in surmounting hurdles such as efficient drug deposition, penetration through lung biological barriers, and ensuring controlled and sustained release. By exploring the utilization of cutting-edge technologies and materials, this Research Topic seeks to emphasize their pivotal role in enhancing therapeutic outcomes and moving toward a more personalized medicine approach in treating conditions like chronic obstructive pulmonary disease (COPD), asthma, and lung cancer.

To gather further insights into the innovative strategies for pulmonary drug delivery systems, we welcome articles addressing, but not limited to, the following themes:

-Nanoparticles, microparticles, and lipid-based carriers for pulmonary delivery
-Aerosol science and optimization of inhalable formulations
-Cyclodextrins and their applications in pulmonary drug delivery
-Microemulsions, micelles, and other nanostructured systems for lung delivery
-Strategies for overcoming lung biological barriers, including mucus penetration and cellular uptake
-Preclinical and clinical studies on pulmonary drug delivery platforms
-Applications of computational modelling and artificial intelligence in designing pulmonary delivery systems
-Safety, toxicity, and regulatory aspects of pulmonary drug delivery systems

The topic editors welcome a variety of article types, such as Original Research, Review, Perspective, Method, or Case Report.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Respiratory Diseases, Pulmonary Drug Delivery, Targeted Drug Delivery, Inhalable Formulations, controlled Release Systems, Nanotechnology, Drug-Loaded Nanoparticles

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.