Green Biomanufacturing by Industrial Microorganisms: Precise Regulation and System Optimization

Under the dual impetus of global carbon neutrality imperatives and bioeconomic transition, contemporary industrial microbiology research confronts the inherent limitations of static regulatory strategies. This urgency demands the development of innovative microbiotechnology frameworks through advanced methodologies, including spatiotemporal metabolic network analysis and dynamic feedback mechanisms, to engineer microbial systems resilient to complex industrial production environments. Such advancements are critical for resolving bottlenecks in scaling laboratory-derived innovations to industrial production. Concurrently, the integration of multi-scale systems biology methods will transcend the dimensional constraints of conventional microbiotechnology, enabling holistic full-chain system spanning molecular mechanisms to factory-scale processes, thereby accelerating intelligent and precision-oriented advancements in green biomanufacturing. Cross-disciplinary convergence is poised to catalyze profound synergies between synthetic biology, artificial intelligence (AI), and emerging frontier disciplines, fundamentally redefining microbial technology development paradigms. Furthermore, establishing a comprehensive life-cycle assessment framework—encompassing industrial efficacy, environmental impact mitigation, biosafety protocols, and ethical governance—will steer microbial-driven green manufacturing from output-centric models toward systemic innovation ecosystems.

This Research Topic initiative aims to curate and disseminate groundbreaking studies and review articles, focusing specifically on microbial technological innovations and their transformative potential in advancing green biomanufacturing by industrial microorganisms. Its core conceptual framework is designed to serve as an interdisciplinary platform that fosters scholarly discourse while catalyzing innovation in both fundamental research and applied practices. By pioneering novel microbial strategies centered on precision regulation and systemic optimization—integrating bioinformatic analyses, multi-omics datasets, and chemical engineering workflows with a substantial microbial component—this research ultimately seeks to establish a closed-loop microbiotechnology innovation system that bridges technological breakthroughs with industrial implementation. This approach will drive a paradigm shift in industrial microbiology—transitioning from foundational scientific inquiry to engineered applications—while accelerating the convergence of biomanufacturing with cutting-edge interdisciplinary fields, thereby redefining industrial sustainability through biologically driven solutions.

To further explore the core themes of this Research Topic, we welcome submissions addressing, but not limited to, the following areas:

• Bioengineering strategies and novel fermentation paradigms for industrial microorganisms.
• Characteristics, diversity, and functional roles of industrial microorganisms for green biomanufacturing.
• Systems-driven analysis of cellular metabolic networks spanning multi-omics integration, molecular coordination mechanisms, and adaptive pathway optimization through engineered biological systems.
• Development of intelligent biomanufacturing systems for industrial microorganisms.
• Innovative technologies and methodologies in green process engineering for industrial microorganisms.
• Frontier interdisciplinary applications: innovative synthetic biology tools, AI-integrated applications, and industrial translational case studies.
• Practical implementations and comprehensive reviews: sustainable industrial practices, bio-product development, and ethical and safety management strategies.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Green Biomanufacturing, Industrial Microorganisms, Precise Regulation, System Optimization

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.