Ranavirus: Host-Pathogen Interaction and Immunity

Ranavirus infections are emerging as significant threats to amphibian, reptilian, and fish populations worldwide, causing severe declines in biodiversity and disrupting ecosystems. As a member of the Iridoviridae family, Ranavirus exhibits complex interactions with their hosts, leading to infectious disease outbreaks that can be devastating in both wild and aquaculture environments. Despite the growing impact of Ranavirus, our understanding of host-pathogen interactions and the immune responses of infected animals remains limited. Research into Ranavirus pathogenesis, immune evasion strategies, and host immunity mechanisms is crucial for improving disease management and developing effective therapeutic and preventative measures. This special issue will highlight the latest advancements in the molecular and immunological aspects of Ranavirus infections, shedding light on how the virus manipulates host defences and influencing disease outcomes.

The goal of this Research Topic is to provide a comprehensive platform for the exploration of Ranavirus-host interactions, with a particular focus on host immune responses and pathogen strategies for evading host defenses. By assembling cutting-edge research in this field, the Research Topic aims to advance our understanding of the molecular mechanisms underlying Ranavirus infections and host resistance. This Research Topic will also highlight novel therapeutic approaches and diagnostic tools that could enhance the management and prevention of Ranavirus outbreaks. This special issue will serve as an essential resource for researchers, clinicians, and policymakers seeking to address the challenges posed by Ranavirus in wildlife conservation and aquaculture.

This Research Topic invites manuscripts that investigate the diverse aspects of Ranavirus infections in amphibians, reptiles, and fish, with a focus on host-pathogen interactions, immune defenses, and emerging control strategies. We welcome both original research articles and comprehensive reviews that offer insights into these areas, aiming to bridge the gap between basic research and applied solutions. Topics of interest include but are not limited to:

• Ranavirus pathogenesis and host susceptibility
• Host immune responses to Ranavirus infection (innate and adaptive immunity)
• Viral immune evasion mechanisms
• Molecular and genetic factors influencing host resistance
• The role of environmental stressors in disease dynamics
• Vaccine development and immunotherapies
• Epidemiology and diagnostic approaches for Ranavirus detection in wild and farmed populations
• Host response to Ranavirus-chytrid fungus co-infection