Phytochemistry and Ethnopharmacology of Natural Bioactive Products against Inflammation and Neurodegeneration

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REVIEW

Published on 24 Sep 2026

Traditional Chinese botanical medicines and plant-derived bioactive compounds in amyotrophic lateral sclerosis: mechanistic evidence, translational challenges, and therapeutic opportunities

Mengfan Li
Ronghao Li
Zhe Deng
Liqun Zhang
Shimeng Lv
Jinjing Shi
Haoteng Ma
Wenhui Guan
Han Zhang
1 more
Jing Teng

doi 10.3389/fphar.2026.1918967

1,239 views

ORIGINAL RESEARCH

Published on 04 Sep 2026

Alismatis Rhizoma prevents AβO-induced neuronal cell death and synaptic loss in Alzheimer’s disease models

Seungmin Lee
In Gyoung Ju
Minji Lee
Jin Hee Kim
Yujin Choi
Chanmi Baek
Chan Kim
Kyuho Moon
Minho Moon
1 more
Myung Sook Oh

doi 10.3389/fphar.2026.1898356

903 views

ORIGINAL RESEARCH

Published on 25 Aug 2026

Naringenin as a dual-target modulator of RAGE–NF-κB signaling and Aβ fibrillization in Alzheimer’s disease: integrated computational and experimental analyses

Inderjeet Bhogal
Ivo Frydrych
Ajay Modi
Vaishali Pankaj
Akhil Kumar
Amit Khairnar
Viswanath Das
Sudeep Roy

doi 10.3389/fphar.2026.1901236

1,039 views

ORIGINAL RESEARCH

Published on 17 Aug 2026

Astragalus polysaccharide alleviates neuropathology and cognitive deficits by modulating gut microbiota and neuroinflammation in an Alzheimer’s disease model

Xiaoli Cui
Zhen Wei
Qingshui Wang
Sizhe Du
Zi Lin
Zibo Chen
Jie Zhang
Chao Li
Lanfang Tang
1 more
Weidong He

doi 10.3389/fphar.2026.1830927

1,073 views

ORIGINAL RESEARCH

Published on 22 Jun 2026

Bruceine E, a natural quassinoid from Brucea javanica, inhibits PARthanatos via targeting PARP1 in ischemic stroke

Chang Wei
Chun-ze Zhai
Chang-ling Yue
Yi-zhe Wang
Yin Cao
Qian-wen Yang
Zhao-huan Zhang
Xiao-hui Xu

doi 10.3389/fphar.2026.1843673

1,034 views
1 citation

ORIGINAL RESEARCH

Published on 15 Jun 2026

Fucoxanthin attenuates carbonyl stress and neuroinflammation by modulating MGO/RAGE/NF-κB axis in Aβ-induced models

Nayoung Lee
Kumju Youn
Huiyoung Kwon
Dong Hyun Kim
Chi-Tang Ho
Mira Jun

doi 10.3389/fphar.2026.1811183

1,033 views

ORIGINAL RESEARCH

Published on 19 May 2026

Unveiling the neuroprotective effects of pomegranate extract and/or physical activity against aluminum chloride-induced Alzheimer’s disease in rats: modulation of multitude pathways

Ahmed M. E. Hamdan
Hadil Alahdal
Haider F. S. Al-Zubaidy
Karema Abu-Elfotuh
Enji Reda
Yasmen F. Mahran
Asmahan Alghamdi
Heba Abdelnaser Aboelsoud
Samia A. Ismael
7 more
Ayah M. H. Gowifel

doi 10.3389/fphar.2026.1793211

2,308 views

ORIGINAL RESEARCH

Published on 04 May 2026

Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization

Jiacan Xu
Pengyu Hao
Jie Chen
Diqi Mai
Ying Wang
Ran Chen
Jiani Yang
Renjie Li
Xiaoyu Xing
3 more
Bodong Wang

doi 10.3389/fphar.2026.1797078

1,385 views
1 citation

ORIGINAL RESEARCH

Published on 29 Apr 2026

Anxiolytic and cognitive effects of dietary phenolics in zebrafish: rosmarinic acid, gallic acid, and 3-hydroxytyrosol

Tugba Ucar Akyurek
Ilkay Erdogan Orhan
Fatma Sezer Senol Deniz
Ion Brinza
Razvan Stefan Boiangiu
Lucian Hritcu

doi 10.3389/fphar.2026.1801073

1,264 views

SYSTEMATIC REVIEW

Published on 23 Feb 2026

Natural compounds as multitarget agents in Alzheimer’s diseases: evidence from in vivo and in vitro models

Vicko Suswidiantoro
Kim San Tang
Khalid Rahman
Donna Maretta Ariestanti
Richard Johari James
Choo Chee Yan
Mitsuyasu Kato
Fadlina Chany Saputri

doi 10.3389/fphar.2026.1766470

2,314 views
7 citations

ORIGINAL RESEARCH

Published on 07 Nov 2025

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties

Sadaf Abdian
Sajad Fakhri
Amir Kiani
Mohammad Mehdi Gravandi
Fatemeh Abbaszadeh
Mohammad Hosein Farzaei
Ehsan Mohammadi-Noori
Javier Echeverría

doi 10.3389/fphar.2025.1691130

13,457 views
2 citations

REVIEW

Published on 19 Sep 2025

Research progress on plant-derived natural compounds regulating the MAPK signaling pathway for the prevention and therapy of Alzheimer’s disease

Xinyue Zhang
Shujia Huang
Hongfeng Xu
Yanan Hu
Ling Gao

doi 10.3389/fphar.2025.1666082

6,578 views
12 citations

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Articles

Traditional Chinese botanical medicines and plant-derived bioactive compounds in amyotrophic lateral sclerosis: mechanistic evidence, translational challenges, and therapeutic opportunities

Alismatis Rhizoma prevents AβO-induced neuronal cell death and synaptic loss in Alzheimer’s disease models

Naringenin as a dual-target modulator of RAGE–NF-κB signaling and Aβ fibrillization in Alzheimer’s disease: integrated computational and experimental analyses

Astragalus polysaccharide alleviates neuropathology and cognitive deficits by modulating gut microbiota and neuroinflammation in an Alzheimer’s disease model

Bruceine E, a natural quassinoid from Brucea javanica, inhibits PARthanatos via targeting PARP1 in ischemic stroke

Fucoxanthin attenuates carbonyl stress and neuroinflammation by modulating MGO/RAGE/NF-κB axis in Aβ-induced models

Unveiling the neuroprotective effects of pomegranate extract and/or physical activity against aluminum chloride-induced Alzheimer’s disease in rats: modulation of multitude pathways

Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization

Anxiolytic and cognitive effects of dietary phenolics in zebrafish: rosmarinic acid, gallic acid, and 3-hydroxytyrosol

Natural compounds as multitarget agents in Alzheimer’s diseases: evidence from in vivo and in vitro models

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties

Research progress on plant-derived natural compounds regulating the MAPK signaling pathway for the prevention and therapy of Alzheimer’s disease

Frontiers in Pharmacology

Neuropharmacology

Other participating journals

Frontiers in Neuroscience

Neuropharmacology