Dedicated to the future of cancer treatment, this topic covers emerging targeted and immunotherapeutic approaches in solid tumors and hematologic malignancies. It emphasizes breakthroughs in small molecule design or new applications, cell-based therapies, immune modulation, and epigenetic reprogramming, paving the way for next-generation oncology care.
The primary goal of this research topic is to advance the understanding and development of emerging targeted and immunotherapeutic strategies in oncology, with a focus on both solid tumors and hematologic malignancies. By integrating insights from small molecule therapies, immune-based approaches, and epigenetic modulation, the aim is to uncover novel mechanisms of action, address therapeutic resistance, and contribute to the refinement of personalized cancer treatments, thereby improving clinical outcomes and patient survival.
This research topic welcomes original research articles, reviews, mini-reviews, case reports, and perspectives focusing on innovative targeted and immunotherapeutic strategies in oncology. Contributions may explore solid tumors and hematologic malignancies, with emphasis on novel small molecules, monoclonal antibodies, CAR-T cell therapies, immune checkpoint modulation, bispecific antibodies, and epigenetic therapies. Studies addressing mechanisms of drug resistance, biomarker discovery, and translational research bridging laboratory findings to clinical applications are highly encouraged. Innovative in vivo and in vitro studies based on 3D models (spheroids/organoids, bioprinted models) are encouraged as well. Authors should highlight advances that contribute to improving the efficacy, specificity, and personalization of cancer treatment. Multidisciplinary approaches and emerging technologies are also within the scope.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Clinical Trial
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Clinical Trial
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Review
Technology and Code
Keywords: Targeted therapies, Malignancies, Small molecules, Drug repositioning, Immunetherapies
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
