Clay-based Nanomaterials: Overcoming Multidrug Resistance in Cancer Therapy

Multidrug resistance (MDR) in cancer remains a crucial challenge, primarily due to the capacity of cancer cells to withstand multiple chemotherapy agents. This resilience significantly reduces the effectiveness of available treatments, driving the quest for innovative therapeutic strategies and advanced drug delivery systems. Among various potential solutions, clay minerals stand out due to their innate biocompatibility and unique physicochemical properties. These naturally sourced materials are being explored as effective drug carriers with the potential to improve drug uptake and persistence in cancerous tissues. Such advancements could lead to significantly enhanced therapeutic outcomes, providing renewed hope for the efficacy of cancer treatments.

This Research Topic aims to investigate the innovative application of clay-based nanomaterials in addressing MDR in cancer therapy. It intends to answer pivotal questions on the interactions between these nanomaterials and biological systems, notably their role in boosting the bioavailability and potency of anticancer drugs. The goal is to evaluate their abilities to create advanced, biocompatible therapeutic platforms that can disrupt the complex resistance pathways in cancer cells, thereby providing new avenues for intervention.

To gather further insights into the boundaries and opportunities of clay-based nanomaterials in cancer drug delivery strategies, we welcome articles addressing, but not limited to, the following themes:

• Detailed exploration of how clays interact with cancer cells, tissues, and biomolecules
• Cutting-edge design of clay-centered carriers and drug delivery solutions
• Comparative analysis of natural versus modified clays in novel medical applications
• Assessment of clay minerals' biocompatibility and safety in therapeutic uses
• Interdisciplinary strategies leveraging clays to surmount MDR in cancer

We invite contributions in the form of reviews, full papers, and communications focused on these themes to advance our understanding and strategic application of clay minerals in overcoming multidrug resistance in cancer therapy.