Renal Pharmacology in Hypertension: The Importance of Specific Treatment for Women

Hypertension continues to present as a significant global health challenge, contributing notably to cardiovascular disease morbidity and mortality rates, as well as to the burden of chronic kidney disease (CKD). Increasing recognition of gender differences in pharmacological responses has highlighted the urgent need to better understand renal pharmacology in hypertensive women. Historically, medical research has prioritized male subjects, resulting in a knowledge gap in understanding women's responses to antihypertensive treatments. Gender-specific physiological changes, such as puberty, pregnancy, and menopause, can impact both renal function and blood pressure regulation, underscoring the need for tailored therapeutic approaches for women.

This Research Topic aims to address these disparities by exploring the facets of renal pharmacology unique to women, particularly regarding hypertension management. By investigating differences in pharmacokinetics and pharmacodynamics, we aim to identify gender-specific therapeutic responses that optimize treatment efficacy and safety among women with hypertension. The kidneys' pivotal role in blood pressure regulation through mechanisms like fluid balance and the renin-angiotensin-aldosterone system (RAAS) is gaining attention for its variation across genders. Understanding the interaction between renal function, hormonal changes, and drug efficacy can lead to more effective female-centric treatment protocols.

The scope of this Research Topic is focused on illuminating the influence of gender differences in renal function on hypertension management, with particular emphasis on women's unique physiological contexts. We welcome articles addressing, but not limited to, the following themes:

o The impact of renal hemodynamics and hormonal fluctuations on hypertension in women

o Gender differences in antihypertensive pharmacokinetics and pharmacodynamics

o Innovative pharmacological treatments targeting RAAS and other regulatory systems

o Development of clinical guidelines incorporating gender-specific recommendations

o Exploration of precision medicine and biomarkers for hypertension in women

By involving a multidisciplinary discussion among experts in pharmacology, nephrology, endocrinology, and gynaecology, this Research Topic seeks to foster awareness and promote progress in personalized medicine for hypertensive women. Articles in this collection should contribute to closing the care gap in women's health, improving treatment outcomes, and enriching the pharmacological knowledge base. We are eager to receive submissions that align with these focal areas and anticipate significant advancements in the management of hypertension in women.