Exploring the Gut Microbiota-Host Interaction through Omics: From Metabolite Profiling to Therapeutic Strategies

The interplay between gut microbiota and host health is a burgeoning area of investigation in microbiology and infection science. Microbial commensals within the gut microbiome produce a wide array of metabolites that serve as signalling molecules, nutrients, or toxins, fundamentally affecting host physiological pathways. These metabolites are crucial in regulating gut homeostasis and influencing systemic processes, such as neuroinflammation. Yet, the complexity of their interactions, particularly concerning metabolic syndrome, liver injury, autoimmune disorders, and cancer, remains inadequately understood. Leveraging the power of omics technologies enables in-depth profiling of microbial communities along with their gene products and the resultant metabolite landscapes, offering new insights into these complex interactions. Despite these advances, there remains a need to further elucidate the causal mechanisms and establish clear links between specific metabolites and host responses, particularly to identify potential biomarkers and therapeutic targets.

This Research Topic aims to deeply explore the intricate relationships between gut microbiota and host health, particularly examining how multi omics approaches can advance our understanding of personalized nutrition and the crucial role of diet-gut microbiota-metabolite networks in maintaining host health. By fostering a cross-disciplinary dialogue, including microbiologists, immunologists, systems biologists, computational scientists, and clinicians, this initiative aspires to merge fundamental discoveries with practical clinical applications. The goal is to unravel novel insights into the interactions between microbial metabolites and host pathways, ultimately contributing to the identification of biomarkers and the development of targeted therapeutic strategies.

To gather further insights into this expanding field, the scope of this research encompasses understanding the multifaceted gut microbiota, microbiome-derived metabolites, and their influence on host health. We welcome articles addressing, but not limited to, the following themes:
o Innovations in research on gut microbiota-host health interactions
o Challenges in translating microbiome research into clinical practice
o Contributions to the development of precision medicine through dietary interventions
o Biochemical network mapping of diet-microbe-metabolite interconnections
o Mechanistic studies on microbial metabolite activities and their implications for metabolic health
Contributions such as original research, reviews, and methodological advancements are especially encouraged to provide deeper insight into these dynamic diet-microbe-metabolite networks, paving the way towards the future of precision medicine.