Insights into the Molecular and Cellular Mechanisms of Insulin Resistance

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ORIGINAL RESEARCH

Published on 11 Aug 2026

Associations between novel triglyceride glucose and adiposity-related indices and risk of metabolic dysfunction-associated steatotic liver disease: the mediating role of biological aging and evidence from the UK Biobank

Kun Wang
Renfang Han
Yueqing Huang
Jingfen Cai
Xiadi Wu

doi 10.3389/fendo.2026.1915819

346 views

ORIGINAL RESEARCH

Published on 24 Jul 2026

Machine learning and bioinformatics identify and validate membrane protein biomarkers for type 2 diabetes mellitus

Tong Liu
Zhaoyuan Tang
Zulipikaer Aierken
Jie Zhang
Cheng Lei

doi 10.3389/fendo.2026.1805548

552 views

SYSTEMATIC REVIEW

Published on 21 Jul 2026

Integrative functional bioinformatic analysis of NAD+-associated protein coding genes in adipose tissue (dys)function – evidence from targeted rodent transcriptomic studies

Filip Postolov
Dragan Milenkovic
Tatjana Ruskovska

doi 10.3389/fendo.2026.1807667

774 views

ORIGINAL RESEARCH

Published on 16 Jul 2026

IGFBP-1 is associated with IRS signaling upregulation and contributes to metabolic recovery post-Roux-en-Y bypass

Tengfei Qi
Ru Ji
Liangping Wu
Jipei He
Hongbin Zhang
Zhengyong Xie

doi 10.3389/fendo.2026.1859266

719 views

ORIGINAL RESEARCH

Published on 12 May 2026

Zinc oxide nanoparticles mitigate insulin resistance in a D-galactose-induced C57BL/6 mouse model

Kanagavalli Ramasubbu
Devi Rajeswari V.

doi 10.3389/fendo.2026.1819985

1,362 views

CASE REPORT

Published on 08 May 2026

Inavolisib-induced fulminant-like diabetes and hyperosmolar hyperglycemic state: a case report

Hongyu Li
Chenxiang Cao
Lixia Jin
Jianzhong Xiao
Wenhui Zhao
Xiaojing Wang

doi 10.3389/fendo.2026.1747317

1,157 views
1 citation

SYSTEMATIC REVIEW

Published on 13 Apr 2026

Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review

Mikołaj Kisiała
Wiktoria Mazepa
Dominika Bauer
Patrycja Tabaka
Michał Gas
Aleksander Sowiński
Krzysztof Wolak
Albert Synal
Julia Gąsiorowska
4 more
Zygmunt Domagała

doi 10.3389/fendo.2026.1810805

3,481 views
3 citations

ORIGINAL RESEARCH

Published on 02 Mar 2026

Association between the triglyceride-glucose index and risk of type 2 diabetes mellitus and the mediating effect of BMI: a comparative analysis in Chinese and Japanese populations

Yuxian Chen
Haiyong Zeng
Ziqi Luo
Haofei Hu
XinYu Wang

doi 10.3389/fendo.2026.1701371

1,482 views

ORIGINAL RESEARCH

Published on 07 Jan 2026

Cangfu Daotan decoction treats PCOS-IR through the IL6/JAK2/STAT3/FOXO4 signaling pathway

Wenhan Ju
Qianwen Zhang
Yue Wang
Keying Pan
Yuan Li
Shuai Zhao
Fang Lian

doi 10.3389/fendo.2025.1661000

2,724 views

ORIGINAL RESEARCH

Published on 15 Dec 2025

Enhancing insulin secretion by pancreatic β-cell redifferentiation: a study of the anti-diabetic effects of berberine in vitro

Jing-Jing Xing
Wei Li
Chen Chen

doi 10.3389/fendo.2025.1658671

3,077 views

ORIGINAL RESEARCH

Published on 12 Dec 2025

Insulin resistance and its association with coronary heart disease: insights from bioinformatics analysis

Xinyue Lu
Minghuan Liu
Yang Song
Shiying Lin
Xiaowan Zhou
Hang Zeng
Aina Li
Huangyuan Li
Xiaoxu Xie
1 more
Siying Wu

doi 10.3389/fendo.2025.1730801

2,817 views
1 citation

CLINICAL TRIAL

Published on 18 Nov 2025

Postexercise immune-inflammatory improvement in type 2 diabetes is associated with baseline insulin resistance

Wei Cheng
Kai Guo
Xuelian Zhang
Keqin Zhang

doi 10.3389/fendo.2025.1679142

2,583 views
1 citation

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Frontiers in Endocrinology

Molecular and Structural Endocrinology

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Articles

Associations between novel triglyceride glucose and adiposity-related indices and risk of metabolic dysfunction-associated steatotic liver disease: the mediating role of biological aging and evidence from the UK Biobank

Machine learning and bioinformatics identify and validate membrane protein biomarkers for type 2 diabetes mellitus

Integrative functional bioinformatic analysis of NAD+-associated protein coding genes in adipose tissue (dys)function – evidence from targeted rodent transcriptomic studies

IGFBP-1 is associated with IRS signaling upregulation and contributes to metabolic recovery post-Roux-en-Y bypass

Zinc oxide nanoparticles mitigate insulin resistance in a D-galactose-induced C57BL/6 mouse model

Inavolisib-induced fulminant-like diabetes and hyperosmolar hyperglycemic state: a case report

Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review

Association between the triglyceride-glucose index and risk of type 2 diabetes mellitus and the mediating effect of BMI: a comparative analysis in Chinese and Japanese populations

Cangfu Daotan decoction treats PCOS-IR through the IL6/JAK2/STAT3/FOXO4 signaling pathway

Enhancing insulin secretion by pancreatic β-cell redifferentiation: a study of the anti-diabetic effects of berberine in vitro

Insulin resistance and its association with coronary heart disease: insights from bioinformatics analysis

Postexercise immune-inflammatory improvement in type 2 diabetes is associated with baseline insulin resistance

Frontiers in Endocrinology

Molecular and Structural Endocrinology