Sepsis is a critical issue in the field of infectious diseases and immunology, posing a significant challenge to global health due to its high morbidity and mortality rates. Emerging from initial hyper-inflammatory responses to infections, sepsis advances into widespread organ dysfunction and immunosuppression, rendering patients susceptible to subsequent infections. Central to this complexity are the dual roles of inflammation and immune suppression, which underscore the crucial need for comprehensive understanding and intervention. Recent studies have advanced our understanding of these mechanisms, yet many questions remain, particularly regarding the molecular underpinnings and variable patient responses. Despite technological advances and increasing genomic data linking genetic predispositions to sepsis outcomes, significant gaps in effective treatments and diagnostics persist.
This Research Topic aims to illuminate the multifaceted pathogenesis of sepsis alongside investigating the intricate pathophysiology across various organs such as the lungs, liver, brain, kidneys, bones, skin, eyes, prostate, and heart. Our objective is to drive forward research that not only clarifies these relationships but also harnesses genomic studies to pinpoint critical functional genes, explore mechanisms of organ-specific susceptibility, and identify promising therapeutic targets. By integrating clinical observations with experimental research, we aim to enhance the fidelity of diagnostics and the efficacy of therapeutic interventions.
To gather further insights into these multi-layered interactions and improve patient outcomes, we invite both original research articles and reviews addressing, but not limited to, the following themes:
Nature, etiology, and pathophysiology of sepsis
Biologically relevant aspects of the epidemiology, diagnosis, and treatment of sepsis
Innovative strategies in sepsis drug discovery and development
Integrative approaches in basic and clinical pharmacology of sepsis
Bridging insights between genomic studies and practical clinical applications
We encourage contributions that can deepen the understanding of sepsis and propel advancements in therapeutic methodologies.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Clinical Trial
Data Report
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Clinical Trial
Data Report
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Review
Systematic Review
Technology and Code
Keywords: Sepsis, Pathogenesis, Pathophysiology, Epidemiology, Pharmacology, Drug development
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
