Juvenile Idiopathic Arthritis: Pathogenesis, Management of Complications, and Treat-to-target

Rheumatology encompasses a range of conditions affecting muscles, bones, and surrounding tissues, significantly impacting pediatric health. Among these conditions, juvenile idiopathic arthritis (JIA) stands out as the most prevalent chronic rheumatic disease in children. Recent advancements have significantly improved our comprehension of JIA, including its pathogenesis, classification, disease activity metrics, targeted therapies, and complication management. Researchers have extensively studied these areas, leading to a better yet incomplete understanding of the disease.

This Research Topic aims to illuminate the ongoing challenges and urgent issues surrounding JIA management and treatment. By focusing on the emergent complexities and unaddressed questions, the goal is to drive forward the understanding and treatment protocols for this debilitating condition. Key objectives include exploring the underpinnings of JIA pathogenesis, identifying potential biomarkers, and enhancing management strategies for associated complications such as macrophage activation syndrome, uveitis, and interstitial lung disease.

To provide broad insights into JIA, this Research Topic encourages a global submission of original studies, including basic research and clinical findings. We seek contributions across a range of topics, but not limited to:



•Pathophysiology and potential markers of JIA

•Treatment protocols for complications like macrophage activation syndrome and uveitis

•Advances in biological therapies targeting JIA

•Clinical management of interstitial lung disease in JIA patients

•Comprehensive reviews and analyses of current JIA treatment strategies



Submissions may include original basic or clinical research, systematic reviews, treatises, commentaries, and case reports aimed at fostering discussion and furthering knowledge among pediatric rheumatologists.