Bacterial infections linked to medical devices, implants, and chronic wounds remain a critical healthcare challenge, intensified by multidrug resistance and biofilm persistence. Innovative solutions are emerging at the crossroads of immuno-materials, antimicrobial biomaterials, and tissue engineering. Multifunctional bioactive surfaces, antimicrobial coatings, and bio- and nanomaterials for personalized medicine—together with sustainable biopolymers from marine sidestreams—offer strategies to prevent colonization, regulate inflammation, and promote regeneration. Regenerative therapies further enhance healing. By integrating infection control, immunomodulation, and tissue restoration, this interdisciplinary field opens new horizons for sustainable, patient-specific interventions against device-associated and chronic wound infections.
The goal of this Research Topic is to collect cutting-edge research articles, comprehensive reviews, and perspectives focused on the design, development, and application of advanced biomaterials with integrated antimicrobial, immunomodulatory, and regenerative properties. These biomaterials aim to address the critical challenge of infection prevention and treatment in medical devices, implants, and chronic wounds, where bacterial colonization, biofilm formation, and multidrug resistance often compromise therapeutic success.
Contributions are encouraged in diverse and complementary areas, including the development of immuno-materials that modulate the host immune response, bio- and nanomaterials engineered for personalized medicine, and sustainable biopolymers for wound healing applications. Innovative multifunctional surfaces designed to inhibit bacterial adhesion while promoting tissue regeneration are also within the scope, alongside tissue engineering strategies that harness biomaterial-mediated immune regulation for enhanced healing.
By fostering interdisciplinary collaboration across materials science, microbiology, immunology, and regenerative medicine, this Research Topic seeks to advance novel therapeutic approaches that bridge infection management with immune modulation and tissue regeneration. Ultimately, the collected contributions aim to pave the way for effective, sustainable, and patient-tailored biomaterial-based interventions, improving clinical outcomes in the management of implant-associated and chronic wound infections
We invite submissions of Original Research articles, which are strongly preferred, as well as high-quality Reviews, Perspectives, and Short Communications related to advanced biomaterials for infection prevention, immunomodulation, and tissue regeneration. Manuscripts should present novel experimental, computational, or clinical findings with clear relevance to the design and application of antimicrobial, immuno-material, and regenerative systems. Contributions that offer mechanistic insights and demonstrate potential for clinical translation are particularly encouraged. While comprehensive reviews are welcome, priority will be given to original studies that advance the field through new data and innovative approaches. Multidisciplinary research spanning materials science, microbiology, immunology, and biomedical engineering is highly valued. All submissions must adhere to the journal’s formatting guidelines and will undergo thorough peer review.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
