Molecular Mechanisms in Psychiatry: Anxiety and Stress, Volume II

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 16 March 2026

  2. This Research Topic is currently accepting articles.

Background

Following the success of the first volume in this series, Frontiers in Psychiatry presents "Molecular Mechanisms in Psychiatry: Anxiety and Stress, Volume II".

Stress is a common experience and a natural response to challenges in our daily lives. However, chronic stress can lead to a wide range of health problems, including mental health disorders such as anxiety and depression, as well as physical health disorders such as cardiovascular disease and obesity. Despite the significant impact of stress on health, the underlying molecular mechanisms that mediate these effects are not yet fully understood.

This Research Topic aims to bring together cutting-edge research on the molecular mechanisms of stress disorders from a variety of disciplines, including genetics, neurobiology, and pharmacology. We invite Original Research articles, Reviews, and Perspectives that cover the following topics:

• the genetic basis of stress disorders: recent advances in identifying genetic risk factors for stress-related disorders, including anxiety, depression, and post-traumatic stress disorder

• the role of neurotransmitters in stress disorders: the role of serotonin, norepinephrine, and other neurotransmitters in the pathophysiology of stress-related disorders

• cellular signaling pathways in stress disorders: the role of intracellular signaling pathways, such as the hypothalamic-pituitary-adrenal axis, in the development and progression of stress-related disorders

• brain imaging studies of stress disorders: recent advances in identifying brain regions involved in the stress response

• emerging therapies for stress disorders: novel therapeutic targets and approaches for the treatment of stress-related disorders, including non-pharmacological interventions such as mindfulness-based interventions, cognitive-behavioral therapy, and other behavioral therapies.

We particularly encourage submissions that explore new avenues for the development of targeted therapies for stress disorders and that highlight the translational potential of research on the molecular mechanisms of stress.

With this Research Topic, we aim to provide a comprehensive overview of the current state of research on the molecular mechanisms of stress disorders and to highlight new directions for future research. We welcome submissions from a variety of disciplines, including genetics, neurobiology, pharmacology, and psychology.

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Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Clinical Trial
  • Community Case Study
  • Data Report
  • Editorial
  • FAIR² Data
  • General Commentary
  • Hypothesis and Theory

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: anxiety, stress, PTSD, molecular mechanisms

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

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