Post-translational modifications (PTMs) are essential biochemical changes that proteins undergo after synthesis, playing a crucial role in regulating protein stability, localization, activity, and interaction with other molecules. In cancer biology, these modifications, including phosphorylation, ubiquitination, acetylation, and glycosylation, are central to processes such as tumorigenesis, immune evasion, and resistance to therapies. With advancements in proteomics and bioinformatics, there is an increased capacity to thoroughly characterize PTMs, highlighting their potential as therapeutic targets and biomarkers in cancer immunotherapy. Nevertheless, the precise mechanisms by which PTMs influence tumor-immune interactions and their implications for immunotherapy are not yet fully understood.
This Research Topic aims to investigate the influence of PTMs on shaping immune responses and tumor progression, particularly focusing on their effect on immunotherapy efficacy. The goal is to discover novel PTM-related strategies that could enhance the effectiveness of cancer immunotherapies, thereby improving patient outcomes. We encourage submissions that clarify the molecular mechanisms through which PTMs regulate immune function and their potential for clinical translation. By bridging foundational research with clinical applications, this topic seeks to stimulate novel insights and drive forward the development of cancer immunotherapies.
To gather further insights within the boundaries of PTMs in cancer immunotherapy, we welcome articles addressing, but not limited to, the following themes: • Impact of PTMs on the stability, localization, and ligand-binding ability of immune checkpoint proteins. • Influence of PTMs on immune cell activation and metabolic reprogramming. • Role of PTMs in tumor immune evasion and immune cell dysfunction. • Exploration of PTM-mediated crosstalk between tumor cells and immune or inflammatory cells. • Development of PTM-targeted therapeutic interventions and identifying PTM-dependent biomarkers for predicting immunotherapy response or resistance.
Authors are invited to submit various article types, including original research, comprehensive reviews, and future outlooks, to advance the dialogue on PTMs in tumor immunotherapy.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Review
Study Protocol
Systematic Review
Technology and Code
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
