Stimuli-responsive nanoparticles represent a frontier in biomedical research, offering dynamic and controllable systems capable of responding to specific biological or physicochemical triggers. These smart nanomaterials can be engineered to release therapeutic agents, change conformation, or alter their physicochemical properties in response to stimuli such as pH, temperature, magnetic or electric fields, enzymatic activity, or light. This adaptive behavior makes them particularly promising for applications in targeted drug delivery, precision diagnostics, regenerative medicine, and minimally invasive therapies.
This Research Topic aims to advance the field by collecting original research articles, critical reviews, and perspectives that explore the design, synthesis, characterization, and biomedical application of stimuli-responsive nanoparticles. The goal is to highlight the potential of these smart systems to address unmet clinical needs and to foster interdisciplinary approaches that accelerate their development and implementation in healthcare.
We welcome submissions addressing, but not limited to, the following topics: • Design and synthesis of nanoparticles responsive to physical, chemical, or biological stimuli • Applications in targeted drug delivery, diagnostics, and theranostics • Stimuli-induced modulation of nanoparticle behavior (e.g., shape change, aggregation, degradation) • Computational modeling and simulation of nanoparticle behavior and bio-interactions • Biocompatibility, stability, and pharmacokinetics of responsive nanoparticles • Preclinical and clinical evaluations of stimuli-responsive systems • Multifunctional platforms combining responsiveness with imaging or therapeutic capabilities
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
