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Biosafety and Biosecurity Approaches to Counter SARS-CoV-2: From Detection to Best Practices and Risk Assessments

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Editorial24 August 2021
Editorial: Biosafety and Biosecurity Approaches to Counter SARS-CoV-2: From Detection to Best Practices and Risk Assessments

Hospitals can be a source of new infections. To reduce this possibility, Raventos and Sabata suggested that air curtains equipped with sprayers to nebulize an alcoholic solution could be used in hospitals to disinfect clothing, exposed body parts and objects that passed through to rapidly and economically reduce the In today's world, the requirement for genetic information security is an evergrowing need. The very information that allows us to understand the properties of a pathogen can also be misused through genetic manipulation for potential harm. Schumacher et al. characterized a general genetic information system from biological material collection through long-term data sharing, storage, and application in the context of security. They also discussed the challenges associated with wet and dry laboratories due to distributed devices and systems that are not designed to address the security of genetic information systems and the need for an extensive laboratory system to realize the potential of this emerging field and to protect the bioeconomy of all stakeholders. patients was 12.9% versus 1.8% among those who did not report close contact.

isothermal nucleic acid amplification techniques, which included conventional PCR and loop-mediated isothermal amplification (LAMP) methods, with hybrid techniques such as polymerase chain displacement reaction (PCDR) and a newly developed PCR-LAMP method. Based on their evaluation, they concluded that hybrid methods exhibited higher sensitivity and assay reaction rates than the classic LAMP-and PCR-based methods.To ascertain early warning signs for severe and critical patients with COVID-19, Xu et al. performed a quantitative analysis of chest CT images at the lung segment level. Their analysis showed that lung involvement in the ordinary and severe/critical groups reached a peak on the 18th and 14th day, respectively. In the first stage, the percentage of lung involvement (PLI) in the right middle lobe and the left superior lobe were significantly different between the two groups. In the second stage and the fourth stage, there were statistically significant differences in PLI between the two groups in the whole lung, right superior lobe, right inferior lobe and left superior lobe. They observed that the rapid progress of the lateral segment of the right middle lobe on the second day and the anterior segment of the right upper lobe on the 13th day may be an early warning sign for severe/critical patients. In addition to the contribution of these scientists toward our understanding of COVID-19 response, scientists from around the world are working to enhance our knowledge and understanding about this virus and trying to identify ways to counter and eradicate this disease. Even with all of our current understanding, many unanswered questions remain that will be worth exploring. The editors of this Research Topic would like to thank the many scientists for their contribution to our knowledge about this disease and their dedication to public health.

2,259 views

1 citations

ORIGINAL RESEARCH
24 June 2021
Oropharyngeal Probiotic ENT-K12 Prevents Respiratory Tract Infections Among Frontline Medical Staff Fighting Against COVID-19: A Pilot Study
Qiang Wang, 11 more and Junbo Xia

24,539 views

35 citations

ORIGINAL RESEARCH
13 May 2021
Early Warning Information for Severe and Critical Patients With COVID-19 Based on Quantitative CT Analysis of Lung Segments
Xu Yuyun, 3 more and Gong Xiangyang

11,315 views

9 citations

ORIGINAL RESEARCH
6 September 2021
De Novo Powered Air-Purifying Respirator Design and Fabrication for Pandemic Response
Akshay Kothakonda, 18 more and Peter K. Sorger

8,725 views

9 citations

REVIEW
29 September 2021
Critical Capability Needs for Reduction of Transmission of SARS-CoV-2 Indoors

4,804 views

3 citations

Advances in Synthetic Biology and Biosafety Governance
REVIEW
30 April 2021
Advances in Synthetic Biology and Biosafety Governance
Jing Li, 2 more and Wenlin An

23,891 views

75 citations

REVIEW
14 April 2021
Management of SARS-CoV-2 Infection: Key Focus in Macrolides Efficacy for COVID-19
Gaber El-Saber Batiha, 13 more and Helal F. Hetta

11,631 views

16 citations

BRIEF RESEARCH REPORT
29 March 2021
Comparison Between a Standard and SalivaDirect RNA Extraction Protocol for Molecular Diagnosis of SARS-CoV-2 Using Nasopharyngeal Swab and Saliva Clinical Samples
Sofía N. Rodríguez Flores, 4 more and Mario A. Rodríguez-Pérez

5,591 views

16 citations

BRIEF RESEARCH REPORT
26 March 2021
Time Till Viral Clearance of Severe Acute Respiratory Syndrome Coronavirus 2 Is Similar for Asymptomatic and Non-critically Symptomatic Individuals
Nitya Kumar, 4 more and Manaf AlQahtani

4,568 views

14 citations

ORIGINAL RESEARCH
2 March 2021
Performance of a Point of Care Test for Detecting IgM and IgG Antibodies Against SARS-CoV-2 and Seroprevalence in Blood Donors and Health Care Workers in Panama
Alcibiades Villarreal, 42 more and Amador Goodridge

7,896 views

16 citations

ORIGINAL RESEARCH
18 January 2021
Potential False-Positive and False-Negative Results for COVID-19 IgG/IgM Antibody Testing After Heat-Inactivation
Jie Lin, 11 more and Xinyi Xia

15,489 views

10 citations

Combinations of PCR and Isothermal Amplification Techniques Are Suitable for Fast and Sensitive Detection of SARS-CoV-2 Viral RNA
BRIEF RESEARCH REPORT
4 November 2020
Combinations of PCR and Isothermal Amplification Techniques Are Suitable for Fast and Sensitive Detection of SARS-CoV-2 Viral RNA
Dmitriy A. Varlamov, 3 more and Konstantin B. Ignatov

14,103 views

29 citations

ORIGINAL RESEARCH
23 October 2020
Hot, Humid Air Decontamination of Aircraft Confirmed That High Temperature and High Humidity Are Critical for Inactivation of Infectious, Enveloped Ribonucleic Acid (RNA) Virus
Tony L. Buhr, 18 more and Brooke B. Luck

6,723 views

8 citations

The global covid-19 pandemic puts great pressure on medical resources worldwide and leads healthcare professionals to question which individuals are in imminent need of care. With appropriate data of each patient, hospitals can heuristically predict whether or not a patient requires immediate care. We adopted a deep learning model to predict fatality of individuals tested positive given the patient’s underlying health conditions, age, sex, and other factors. As the allocation of resources towards a vulnerable patient could mean the difference between life and death, a fatality prediction model serves as a valuable tool to healthcare workers in prioritizing resources and hospital space. The models adopted were evaluated and refined using the metrics of accuracy, specificity, and sensitivity. After data preprocessing and training, our model is able to predict whether a covid-19 confirmed patient is likely to be dead or not, given their information and disposition. The metrics between the different models are compared. Results indicate that the deep learning model outperforms other machine learning models to solve this rare event prediction problem.

12,409 views

45 citations

ORIGINAL RESEARCH
20 October 2020
Controlled Heat and Humidity-Based Treatment for the Reuse of Personal Protective Equipment: A Pragmatic Proof-of-Concept to Address the Mass Shortage of Surgical Masks and N95/FFP2 Respirators and to Prevent the SARS-CoV2 Transmission
Louis Bernard, 23 more and Nathalie Heuzé-Vourc'h

10,510 views

14 citations