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Published on 25 Jul 2025

Persistently, intensely grieving relations are nearly twice as likely to die within 10 years after losing a loved one

Researchers followed 1,735 people in Denmark over 10 years after their loss of loved one. 6% participants showed unabatingly high levels of grief symptoms, and these had a 88% higher hazard rate of dying from any cause over the time period than those with persistently low symptoms. The first group were likewise more likely to use healthcare services, with 186% higher odds of receiving talk therapy or other mental health services, and between 160% and 463% higher odds of being prescribed psychotropic medication. This is the first study on the long-term mortality rate and the use of healthcare in a large-scale cohort of bereaved persons. The results suggest that patients at risk for long-term ‘high grief’ may be identified in advance, and need additional support from the healthcare system.

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Published on 18 Jul 2025

Gene essential for vitamin D absorption could help unlock treatments for cancer and autoimmune diseases

Scientists have identified the human gene SDR42E1 as essential for the absorption of vitamin D from the intestine, its subsequent metabolic processing, as well as the production of lipids and steroids. Without the functional protein, the survival of cells dropped by 53%. This discovery has at least two potential applications in precision medicine. First, the experiments showed that the gene can be blocked to selectively kill cancer cells. Second, boosting SDR42E1’s expression could help treat many other diseases, for example, autoimmune and metabolic disorders, against which vitamin D and its related forms are thought to protect.

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