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Front. Chem. | doi: 10.3389/fchem.2019.00014

Metal-Assisted Hydrolysis Reactions Involving Lipids: A Review

  • 1Department of Chemistry, School of Arts and Sciences, University of Richmond, United States
  • 2Department of Chemistry, College of Arts & Sciences, Georgia State University, United States

This report covers major advances in the use of metal ions and complexes to hydrolyze ester and phosphate ester lipid bonds. These metal-based Lewis acids have been investigated as catalysts to isolate fatty acids from biological sources, as probes to study phospholipid bilayer properties, as tools to examine signal transduction pathways, and as lead compounds toward the discovery of therapeutic agents. Metal ions that accelerate phosphate ester hydrolysis under mild conditions of temperature and pH may have the potential to mimic phospholipase activity in biochemical applications.

Keywords: Cleavage, Fatty Acids, Liposomes, Enzyme mimics, Triglycerides

Received: 28 Sep 2018; Accepted: 08 Jan 2019.

Edited by:

Rajeev Prabhakar, University of Miami, United States

Reviewed by:

Salah S. Massoud, University of Louisiana at Lafayette, United States
Alfredo M. Angeles-Boza, University of Connecticut, United States
Sanjay Singh, Ahmedabad University, India  

Copyright: © 2019 Williams and Grant. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Kathryn B. Grant, Department of Chemistry, College of Arts & Sciences, Georgia State University, Atlanta, United States, kbgrant@gsu.edu