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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2019.00283

The preparation of hollow mesoporous bioglass nanoparticles with excellent drug delivery capacity for bone tissue regeneration

 Yudong Wang1, 2, Haobo Pan1* and  Xiaofeng Chen2*
  • 1Shenzhen Institutes of Advanced Technology (CAS), China
  • 2South China University of Technology, China

In this work, hollow mesoporous bioglass (HMBG) nanoparticles were prepared in a hexadecyl trimethyl ammonium bromide (CTAB)-cyclonexane-ethanol-water (O/W) emulsion system. The HMBG nanoparticles possessed higher drug storage ability and stable drug release behavior which resulted from HMBG’s unique mesoporous structure. The mesoporous structure could be modulated by adjusting concentration of CTAB. The specific surface area and drug loading efficiency was as high as 749.619 m2g-1 and 55.1%. Besides, in vivo experiments demonstrated that the HMBG nanoparticles could promote the bone tissue regeneration and the drug-loading HMBG nanoparticles possessed better repair capability. The unique structure and properties might make the HMBG nanoparticles good candidates as drug carriers and repair materials for bone tissue regeneration.

Keywords: hollow structure, Nanoparticles, Bioglass, Drug delivery, Bone repair

Received: 07 Dec 2018; Accepted: 08 Apr 2019.

Edited by:

Tianyou Zhai, Huazhong University of Science and Technology, China

Reviewed by:

Wei Luo, Donghua University, China
Min Zhou, Zhejiang University, China  

Copyright: © 2019 Wang, Pan and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Haobo Pan, Shenzhen Institutes of Advanced Technology (CAS), Shenzhen, China, hb.pan@siat.ac.cn
Prof. Xiaofeng Chen, South China University of Technology, Guangzhou, 510 641, Guangdong Province, China, chenxf@scut.edu.cn