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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2019.00683

Self-healable, Fast Responsive poly(ω-pentadecalactone) Thermogelling System for Effective Liver Cancer Therapy

Huihui Shi1,  Hong Chi2, Zheng Luo3, Lu Jiang4, Xian Jun Loh4, Chaobin He1* and  Zibiao Li4*
  • 1Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, Singapore
  • 2Qilu University of Technology, China
  • 3Xiamen University, China
  • 4Agency for Science, Technology and Research (A*STAR), Singapore

A polyurethane based thermogelling system comprising poly(ω-pentadecalactone) (PPDL), poly(ethylene glycol) (PEG) and poly(propylene glycol) (PPG), termed as PDEP, was synthesized. The incorporation of PPDL lowers critical micelle concentration (CMC) as well as critical gelation concentration (CGC) of the novel copolymers compared to commercial Pluronic® F127. The thermogels showed excellent thermal stability at high temperature up to 80 C, fast response to temperature change in a time frame of less than second, as well as remarkable self-healing properties after being broken at high strain. In vitro drug release studies using docetaxel (DTX) and cell uptake studies using doxorubicin (DOX) show high potential of the hydrogel as drug reservoir for sustainable release profile of payloads, while the in vitro anti-tumor evaluation using mice model of hepatocellular carcinoma further demonstrated the significant inhibition on the growth of tumor. Together with its excellent biocompatibility in different organs, the novel PDPE thermogelling copolymers reported in this work could potentially be utilized as in situ-forming hydrogels for liver cancer therapy.

Keywords: Hydrogel, drug formulation, polymer synthesis, cancer therapy, self-healable, Temperature responsive hydrogel, biodegradable (co)polymers

Received: 17 Aug 2019; Accepted: 01 Oct 2019.

Copyright: © 2019 Shi, Chi, Luo, Jiang, Loh, He and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Chaobin He, Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117575, Singapore,
Dr. Zibiao Li, Agency for Science, Technology and Research (A*STAR), Singapore, 138632, Singapore,