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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2019.00700

Palladium Mesoionic Carbene Pre-Catalyst for General Cross-Coupling Transformations in Deep Eutectic Solvents

  • 1University of Alicante, Spain

A strong -donor mesoionic carbene ligand has been synthesized and applied to four different palladium-catalyzed cross-coupling transformations, proving the catalyst/medium compatibility and the increased activity of this system over previous reports in Deep Eutectic Solvent medium. Some cross-coupling processes could be carried out at room temperature and using aryl chlorides as starting materials. The possible implementation of multistep synthesis in eutectic mixtures has also been explored. The presence of palladium nanoparticles in the reaction media has been evaluated and correlated to the observed activity

Keywords: cross-coupling­, Deep eutectic solvent (DES), Palladium, carbene, Mesoionic

Received: 11 Jun 2019; Accepted: 08 Oct 2019.

Copyright: © 2019 Ramón, Guillena, Marset, Saavedra, González-Gallardo, Beaton, León and Luna. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Diego J. Ramón, University of Alicante, San Vicente del Raspeig, Spain, djramon@ua.es
Prof. Gabriela Guillena, University of Alicante, San Vicente del Raspeig, Spain, gabriela.guillena@ua.es