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Front. Chem. | doi: 10.3389/fchem.2019.00782

Comparison Study of Computational Prediction Tools for Drug-Target Binding Affinities

  • 1Computational Bioscience Research Center, King Abdullah University of Science and Technology, Saudi Arabia

The drug development is generally arduous, costly, and success rates are low. Thus, the identification of drug-target interactions (DTIs) has become a crucial step in early stages of drug discovery. Consequently, developing computational approaches capable of identifying potential DTIs with minimum error rate are increasingly being pursued. These computational approaches aim to narrow down the search space for novel DTIs and shed light on drug functioning context. Most methods developed to date use binary classification to predict if the interaction between a drug and its target exists or not. However, it is more informative but also more challenging to predict the strength of the binding between a drug and its target. If that strength is not sufficiently strong, such DTI may not be useful. Therefore, the methods developed to predict drug-target binding affinities (DTBA) are of great value. In this study, we provide a comprehensive overview of the existing methods that predict DTBA. We focus on the methods developed using artificial intelligence (AI), machine learning (ML), and deep learning (DL) approaches, as well as related benchmark datasets and databases. Furthermore, guidance and recommendations are provided that cover the gaps and directions of the upcoming work in this research area. To the best of our knowledge, this is the first comprehensive comparison analysis of tools focused on DTBA with reference to AI/ML/DL.

Keywords: drug repurposing, Drug-target interaction, drug-target binding affinity, artificial intelligence, machine learning, deep learning, information integration, bioinformatics

Received: 09 Aug 2019; Accepted: 30 Oct 2019.

Copyright: © 2019 Thafar, Raies, Albradei, Essack and Bajic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Vladimir B. Bajic, King Abdullah University of Science and Technology, Computational Bioscience Research Center, Thuwal, 23955-6900, Saudi Arabia,