In the original article, there was an error. We stated that USP8 genetic abnormalities were not identified in DNA from tumor samples analyzed by microarray technology.
A correction has been made to Abstract, Paragraph Number 1, Lines 18–19.
Somatic mutations in USP8 were also investigated and mutations were identified in six cases.
A correction has been made to Results, Paragraph Number 1.
Before microarray analysis, we performed the screening for mutations in USP8 in our patients, and somatic variants were found in patients #2 and #5 (p.Ser718Pro), #4 (p.Ser718Cys), patients #3 and #6 (p.Pro720Arg), and #9 (p.Pro720Gln). Both mutations were found in heterozygosis and have been previously described (17, 18).
A correction has been made to Discussion, Paragraph Number 1.
In the microarray study cohort, we identified six USP8 mutations in 12 samples (50%). In the patients included in the validation study, we could identify somatic USP8 mutations in 5 (non-invasive corticotrophinomas) out of 18 patients (27.7%). According to Reincke et al. (17) and Perez-Rivas et al. (18), these mutations occur in ≈36% of patients with CD. Interestingly, the presence of USP8 mutations did not interfere in the transcriptome expression analysis results comparing invasive vs. non-invasive tumors and in its validation study.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Summary
Keywords
Cushing's disease, gene expression, neuroendocrine tumors, microarray, anterior pituitary
Citation
de Araújo LJT, Lerario AM, de Castro M, Martins CS, Bronstein MD, Machado MC, Trarbach EB and Villares Fragoso MCB (2019) Corrigendum: Transcriptome Analysis Showed a Differential Signature Between Invasive and Non-invasive Corticotrophinomas. Front. Endocrinol. 10:567. doi: 10.3389/fendo.2019.00567
Received
23 May 2019
Accepted
02 August 2019
Published
22 August 2019
Volume
10 - 2019
Edited and reviewed by
Nienke Biermasz, Leiden University, Netherlands
Updates
Copyright
© 2019 de Araújo, Lerario, de Castro, Martins, Bronstein, Machado, Trarbach and Villares Fragoso.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Maria Candida Barisson Villares Fragoso maria.villares@hc.fm.usp.br
This article was submitted to Pituitary Endocrinology, a section of the journal Frontiers in Endocrinology
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