%A Brinkman,C. %A Peske,J. %A Engelhard,Victor %D 2013 %J Frontiers in Immunology %C %F %G English %K T cell trafficking,T cell memory,T cell heterogeneity,tumor infiltrating lymphocytes (TIL),T cell migration,T cell recirculation,Memory T cell trafficking,Effector T cell migration %Q %R 10.3389/fimmu.2013.00241 %W %L %M %P %7 %8 2013-August-19 %9 Mini Review %+ Prof Victor Engelhard,University of Virginia,Microbiology, Immunology, and Cancer Biology,PO Box 801386 MR6 Building, Room 3523,Charlottesville,22908,Virginia,United States,vhe@virginia.edu %# %! Control of T cell homing %* %< %T Peripheral Tissue Homing Receptor Control of Naïve, Effector, and Memory CD8 T Cell Localization in Lymphoid and Non-Lymphoid Tissues %U https://www.frontiersin.org/articles/10.3389/fimmu.2013.00241 %V 4 %0 JOURNAL ARTICLE %@ 1664-3224 %X T cell activation induces homing receptors that bind ligands on peripheral tissue vasculature, programing movement to sites of infection and injury. There are three major types of CD8 effector T cells based on homing receptor expression, which arise in distinct lymphoid organs. Recent publications indicate that naïve, effector, and memory T cell migration is more complex than once thought; while many effectors enter peripheral tissues, some re-enter lymph nodes (LN), and contain central memory precursors. LN re-entry can depend on CD62L or peripheral tissue homing receptors. Memory T cells in LN tend to express the same homing receptors as their forebears, but often are CD62Lneg. Homing receptors also control CD8 T cell tumor entry. Tumor vasculature has low levels of many peripheral tissue homing receptor ligands, but portions of it resemble high endothelial venules (HEV), enabling naïve T cell entry, activation, and subsequent effector activity. This vasculature is associated with positive prognoses in humans, suggesting it may sustain ongoing anti-tumor responses. These findings reveal new roles for homing receptors expressed by naïve, effector, and memory CD8 T cells in controlling entry into lymphoid and non-lymphoid tissues.