%A Hastings,Karen %D 2013 %J Frontiers in Immunology %C %F %G English %K MHC class II,antigen processing and presentation,GILT,Autoimmunity,tumor immunity %Q %R 10.3389/fimmu.2013.00429 %W %L %M %P %7 %8 2013-December-04 %9 Mini Review %+ Prof Karen Hastings,University of Arizona College of Medicine Phoenix,Phoenix,United States,khasting@email.arizona.edu %# %! GILT in CD4+ T cell-mediated immunity %* %< %T GILT: Shaping the MHC Class II-Restricted Peptidome and CD4+ T Cell-Mediated Immunity %U https://www.frontiersin.org/articles/10.3389/fimmu.2013.00429 %V 4 %0 JOURNAL ARTICLE %@ 1664-3224 %X The MHC class II-restricted antigen processing pathway generates peptide:MHC complexes in the endocytic pathway for the activation of CD4+ T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) reduces protein disulfide bonds in the endocytic compartment, thereby exposing buried epitopes for MHC class II binding and presentation. T cell hybridoma responses and elution of MHC class II bound peptides have identified GILT-dependent epitopes, GILT-independent epitopes, and epitopes that are more efficiently presented in the absence of GILT termed GILT-prevented epitopes. GILT-mediated alteration in the MHC class II-restricted peptidome modulates T cell development in the thymus and peripheral tolerance and influences the pathogenesis of autoimmunity. Recent studies suggest an emerging role for GILT in the response to pathogens and cancer survival.