%A Li,Lili %A Li,Jie %A Gao,Meiling %A Fan,Huimin %A Wang,Yanan %A Xu,Xin %A Chen,Chunfeng %A Liu,Junxiao %A Kim,Jocelyn %A Aliyari,Roghiyh %A Zhang,Jicai %A Jin,Yujie %A Li,Xiaorong %A Ma,Feng %A Shi,Minxin %A Cheng,Genhong %A Yang,Heng %D 2021 %J Frontiers in Immunology %C %F %G English %K cytokine serum profile,biomarker,coronavirus disease-2019 prognosis,respiratory syndrome coronavirus 2,Cytokine storm,Interleukin-6,Interleukin-8 %Q %R 10.3389/fimmu.2020.602395 %W %L %M %P %7 %8 2021-January-08 %9 Original Research %+ Genhong Cheng,Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles,United States,yhmyt@hotmail.com %+ Heng Yang,Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College,China,yhmyt@hotmail.com %+ Heng Yang,Cheng Lab, Suzhou Institute of Systems Medicine,China,yhmyt@hotmail.com %# %! IL-8 as a biomarker for COVID-19 disease prognosis %* %< %T Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients %U https://www.frontiersin.org/articles/10.3389/fimmu.2020.602395 %V 11 %0 JOURNAL ARTICLE %@ 1664-3224 %X The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis.