In the original article, there was a mistake in Figure 3A and Supplement 3 as published. In the Figure 3A, the bicuculine group at day 28 post-TAC was inadvertently saved in the improper folders and attached to Sham group at days 14 and 28 post-TAC, so the representative images of Sham group at days 14 and 28 post-TAC were wrong and duplicated. In the Supplement 3, the representative image of Sham group at day 21 post-TAC was chosen by mistake. The corrected Figure 3A and Supplement 3 appear below.
Figure 3
Activation or blockade of the GABAA receptor selectively increases or reduces the number of Ly6Clow macrophages in the hearts of pressure-overload hypertrophy mice. Macrophage (CD45+F4/80+CD11b+) subpopulations were respectively defined as Ly6Chigh or Ly6Clow macrophages according to Ly-6C expression levels. (A) Representative images of Ly6Chigh and Ly6Clow macrophages at days 7, 14, and 28 post-TAC. The representative images of 1, 3, and 21 days after TAC were shown in supplementary materials. (B) The number of Ly6Clow macrophages or Ly6Chigh macrophages (per mg heart tissue) among the total number of live cells isolated from hearts at the indicated time points after TAC. (C) The number of CD45+CD11b+F4/80+EdU+cell (per mg heart tissue) among the total number of live cells isolated from hearts at the indicated time points after TAC. (D) Representative images of Ki-67+ expression in Ly6Clow macrophages at day 7 post-TAC. (E) The percentage of Ki-67+ expression in Ly6Clow macrophages. Data show the mean ± SEM, by one-way ANOVA with Bonferroni’s multiple comparison test. For topiramate treatment, *P < 0.05 vs. vehicle. For bicuculline treatment, #P < 0.05 vs. vehicle. (n = 3 mice for sham group, n = 6–8 mice for all other groups).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Statements
Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2021.753404/full#supplementary-material
Supplement 3Living cells (upper panel) were gated to determine the presence of CD45+Ly6G-CD11b+Ly6Chigh and CD45+Ly6G-CD11b+Ly6Clow monocytes at day 21 post-TAC in the peripheral blood.
Summary
Keywords
GABAA receptor, amphiregulin, macrophage, monocyte, pressure-overload hypertrophy
Citation
Bu J, Huang S, Wang J, Xia T, Liu H, You Y, Wang Z and Liu K (2021) Corrigendum: The GABAA Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice. Front. Immunol. 12:753404. doi: 10.3389/fimmu.2021.753404
Received
04 August 2021
Accepted
24 August 2021
Published
21 September 2021
Volume
12 - 2021
Edited and reviewed by
Guochang Hu, University of Illinois at Chicago, United States
Updates
Copyright
© 2021 Bu, Huang, Wang, Xia, Liu, You, Wang and Liu.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Zhaohui Wang, zhaohuiwang@hust.edu.cn; Kun Liu, liukun@hust.edu.cn
†These authors share first authorship
This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.