In the published article, there was an error in Figure 3 as published. Figure 3 was substituted with Figure 4, which was duplicated. The corrected Figure 3 and its caption appear below.
Figure 3
Stimulation of CD4+ T cells by SEB induces the secretion of inflammatory cytokines in the absence of MHC class II- and B7-expressing APCs. (A–G) Human CD4+ T cells isolated by the peripheral blood of healthy donors (HD) were unstimulated (Med) or stimulated for different times with 1 μg ml-1 SEB. IFN-γ (A), IL-2 (B), IL-6 (C), TNF-α (D), IL-17A (E), IL-22 (F) and GM-CSF (G) levels in culture supernatant were measured by ELISA. Data show the mean ± SEM of different HD (n = 4). Statistical significance was calculated by One-way ANOVA. Means values (pg ml-1): 24 hours; IFN-γ, Med = 0, SEB = 328.7; IL-2, Med = 0, SEB = 1966; IL-6, Med = 92.2; SEB = 249; TNF-α, Med = 0, SEB = 1959; IL-17A, Med = 0, SEB = 251.7; IL-22, Med = 37.4, SEB = 1197; GM-CSF, Med = 19.1, SEB = 916.5. 48 hours; IFN-γ, Med = 0, SEB = 1738; IL-2, Med = 0, SEB = 2600; IL-6, Med = 96.7, SEB = 498.8; TNF-α, Med = 0, SEB = 3361; IL-17A, Med = 0, SEB = 1884; IL-22, Med = 178.6, SEB = 5726; GM-CSF, Med = 22,3, SEB = 3426. 72 hours; IFN-γ, Med = 0, SEB = 3099; IL-2, Med = 0.9, SEB = 2303; IL-6, Med = 95, SEB = 851.5; TNF-α, Med = 2.6, SEB = 3591; IL-17A, Med = 0, SEB = 4211; IL-22, Med = 140.9, SEB = 10737; GM-CSF, Med = 42.3, SEB = 7633. (*) p < 0.05, (**) p < 0.01, (***) p < 0.001, (****) p < 0.0001. NS, not significant.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Summary
Keywords
staphylococcal superantigens, T cells, TCR (T cell receptor), CD28, inflammation
Citation
Kunkl M, Amormino C, Spallotta F, Caristi S, Fiorillo MT, Paiardini A, Kaempfer R and Tuosto L (2023) Corrigendum: Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells. Front. Immunol. 14:1273921. doi: 10.3389/fimmu.2023.1273921
Received
07 August 2023
Accepted
08 August 2023
Published
15 August 2023
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
14 - 2023
Updates
Copyright
© 2023 Kunkl, Amormino, Spallotta, Caristi, Fiorillo, Paiardini, Kaempfer and Tuosto.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Loretta Tuosto, loretta.tuosto@uniroma1.it; Alessandro Paiardini, alessandro.paiardini@uniroma1.it
†Deceased
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.