Corrigendum: Staphylococcus aureus Bacteriophage Suppresses LPS-Induced Inflammation in MAC-T Bovine Mammary Epithelial Cells

In the original article, there was an error. We stated in the article that Previous studies reported that bacteriophages could activate NF-κB signaling and enhance immune effects in vitro (Gorski et al., 2006). In fact, the authors of the aforementioned article reported the exact opposite; that is, they reported a phage-mediated down-regulation of NF-κB activation.

A correction has been made to Discussion, Paragraph 3:

Previous studies reported that bacteriophages can diminish cellular infiltration of allogeneic skin allograft in mice, extend its survival and inhibit human T cell activation in vitro. Furthermore, T4 phage can abolish the ability of the pathogenic virus to induce NF-κB activity (Gorski et al., 2006). In order to prove the relationship between the effects induced by bacteriophages and NF-κB, we determined the expression levels and the phosphorylation of the NF-κB p65 subunit were determined by Western blotting. This part of our work demonstrated that pre-treatment with bacteriophage vB_SauM_JS25 significantly suppressed the phosphorylation levels of NF-κB p65 at 2 h post-LPS-stimulation (p < 0.05, Figure 4). However, once the pre-treatment bacteriophage was removed, the LPS-induced production of cytokines was significantly enhanced (p < 0.001, Figure 3). As reported previously, the lack of dissemination, and the reduced levels of inflammation caused by the production of prophage-created conditions, could promote persistent infection by P. aeruginosa (Secor et al., 2017). Moreover, there may be other mechanisms that bacteriophages use to interact directly with eukaryotic systems and thus modulate the immune system. In these scenarios, bacteriophages appear to act an immunomodulator in order to balance inflammation cytokines.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.

The original article has been updated.

Statements

Summary

Keywords

Staphylococcus aureus, bacteriophage, inflammation, LPS, NF-κB, MAC-T cells

Citation

Zhang L, Hou X, Sun L, He T, Wei R, Pang M and Wang R (2018) Corrigendum: Staphylococcus aureus Bacteriophage Suppresses LPS-Induced Inflammation in MAC-T Bovine Mammary Epithelial Cells. Front. Microbiol. 9:2511. doi: 10.3389/fmicb.2018.02511

Received

02 August 2018

Accepted

02 October 2018

Published

19 October 2018

Volume

9 - 2018

Edited by

Pilar García, Consejo Superior de Investigaciones Científicas (CSIC), Spain

Reviewed by

Andrzej Gorski, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PAN), Poland

Updates

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Copyright

© 2018 Zhang, Hou, Sun, He, Wei, Pang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Ran Wang Wangran2001@126.com

This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology

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