The emergence and exploration of new disciplines and technologies have provided new ideas and opportunities for probiotic science and industry development. The interaction between diet and intestinal flora has become a new target for human health regulation. Recently, probiotic supplements have received increasing attention as an important tool to modulate the gut microbiota (Brito Sampaio et al., 2022). Lactic acid bacteria (LAB) are powerful probiotics in the intestinal tract that can participate in metabolic regulation by directly or indirectly influencing the inhibition or activation of the signaling pathways. LAB can synthesize a variety of active metabolites, producing short-chain fatty acids, vitamins, enzymes, organic acids and antibacterial peptides. These metabolites can regulate the intestinal epithelium's barrier function and provide health benefits to the host.
Studies have found that probiotics have a variety of biological activities (Brito Sampaio et al., 2022; Leite de Souza et al., 2022). However, their application is still limited due to the poor colonization and the unclear mechanism of the induction of metabolites in the host involved in the interaction between pathogens and bacterial communities, etc. Therefore, this Research Topic aimed to collect new studies focused on probiotics and probiotics' metabolites in food and intestine with combined phenotyping, genotyping and targeting strategies as well as the multi-omics technologies.
Chen X. et al. assessed the effects of alkali stress on the growth and menaquinone-7 metabolism of Bacillus subtilis natto, whereas He et al. investigated the effects of Akkermansia muciniphila on gut microbiota and disease-related biomarkers in murine model, finding that this microorganism alters gut microbiota and immune system to improve cardiovascular diseases.
Li et al. demonstrated that autoinducer-2 exporters (AI-2E) family transporter protein in Lactobacillus acidophilus exhibits AI-2 exporter activity and relate with intestinal juice resistance of the strain.
Hu P. et al. isolated and identified Rhodotorula mucilaginosa TZR2014 and assessed its function as well as its effects on the growth and helath of weaned piglets.
Ke et al. demonstrated the inhibition of Cronobacter sakazakii in an infant simulator of the human intestinal microbial ecosystem using a potential synbiotic consisting of six lactic acid bacteria (LAB) strains and Vivinal GOS.
Hu Y. et al. demonstrated the alleviating effects of Selenium-enriched Bifidobacterium longum DD98 on dextran sulfate sodium-induced colitis in mice and explored the underlying mechanism.
Zhao et al. investigated the alleviating effects of gut micro-ecologically regulatory treatments on onstipation in mice.
Chen P. et al. investigated the regulations of lipid metabolism of broilers by Bacillus amyloliquefaciens TL both in vivo and in vitro, whereas Wang et al. demonstrated the exertion by Lactobacillus mucosae of different antiviral effects on respiratory syncytial virus infection in mice.
Sheng et al. discovered a novel exopolysaccharide derived from the probiotic Lactobacillus pantheris TCP102 strain exerting immune-enhancing and anticancer activities.
Finally, Liu et al. provided a review on antifungal mechanisms and application of Lactic Acid Bacteria in bakery products, whereas Shi et al., provided a review on the recent advances in the roles of microorganisms in fermented foods based on multi-omics data.
Statements
Author contributions
VF conceived and wrote the manuscript. All authors revised the manuscript. All authors contributed to the article and approved the submitted version.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1
Brito SampaioK.FuscoVde Brito AlvesJ. L.Leite de SouzaE. (2022). “Chapter 1—Probiotics: concepts, evolution, and applications,” in Probiotics for Human Nutrition in Health and Disease, eds Leite de SouzaE.de Brito AlvesJ. L.FuscoV.Academic Press. ISBN 9780323899086.
2
Leite de SouzaE.de Brito AlvesJ. L.FuscoV eds. (2022). Probiotics for Human Nutrition in Health and Disease. Academic Press. ISBN: 978-0-323-89908-6.
Summary
Keywords
probiotics, prebiotics, food, intestine, metabolites
Citation
Fusco V, Wu R, Zhang W and Zhai Q (2023) Editorial: Role of probiotics and probiotics' metabolites in food and intestine. Front. Microbiol. 14:1183550. doi: 10.3389/fmicb.2023.1183550
Received
10 March 2023
Accepted
16 March 2023
Published
24 March 2023
Volume
14 - 2023
Edited and reviewed by
Giovanna Suzzi, University of Teramo, Italy
Updates
Copyright
© 2023 Fusco, Wu, Zhang and Zhai.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Vincenzina Fusco vincenzina.fusco@ispa.cnr.it
This article was submitted to Food Microbiology, a section of the journal Frontiers in Microbiology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.