In the published article, there was an error in Table 1 as published. The order of the references in Table 1 was incorrect. The corrected Table 1 appears below.
Table 1
| Compound | Mechanism | References |
|---|---|---|
| PRIMA-1 | restore the wild-type conformation to mutant P53 and induce apoptosis in cancer cells | (128) |
| APR-246(PRIMA-1Met) | restore the wild-type conformation to mutant P53 and induce apoptosis in cancer cells reduce glutathione(GSH) and thioredoxin reductase 1 (TXNRD1) increase ROS levels | (129) (130) |
| COTI-2 | promote refolding of mutant p53 and restore wild-type-p53 function lead to activation of AMPK and inhibit the PI3K-AKT pathway | (124, 131) |
| MIRA1 | restore transcriptional transactivation to mutant p53 in living cells | (132) |
| STIMA-1 | preferentially kill mutant p53‐carrying tumor cells activate caspases and induces Bax, PUMA and p21 | (133) |
| Zinc metallochaperone-1 (ZMC1/NSC319726) | activate mutant p53 by restoring proper zinc loading decrease cellular GSH levels and increase ROS levels | (134, 135) |
| PK11007 and other similar compounds(PK11000,PK11010,PK11029,PK11003,PK11012 and PK11015) | alkylation of surface-exposed cysteines 182 and 277 and stabilized the p53 DBD without impairing its DNA-binding affinity increase protein and mRNA levels of the p21 and PUMA decrease cellular GSH levels and increase ROS levels | (126) |
| ReACp53 and related peptides(CDB3) | disrupts mutant-p53 aggregates and stabilise wild-type conformation | (136-138) |
| CP-31398 | protect p53 from thermal degeneration,restore the wild type function of some mutant p53 and up-regulate p53 levels | (139, 140) |
| PhiKan083(PK083) | Binds to the DNA-binding domain of mutant-p53 and restore the wild type function of some mutant p53 | (141-143) |
| RETRA | Treatment of mutant p53-expressing cancer cells with RETRA results in a substantial increase in the expression level of p73 | (144) |
| PC14586 | stabilize the Y220C mutant and restore p53 wild-type (normal) conformation | (145) |
| MDM2 Inhibitor : Nutlin-3 and ALRN-6924 | Increase p53 levels and activity | (146, 147) |
| RG7388 and AMG232 | disrupt the p53-MDM2 protein–protein interaction and prevent p53 from proteasomal degradation | (148, 149) |
Agents that target TP53 mutation.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Publisher’s note
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Summary
Keywords
TP53 mutation, ferroptosis, pyroptosis, apoptosis, autophagic cell death, cancer
Citation
Su Y, Sai Y, Zhou L, Liu Z, Du P, Wu J and Zhang J (2022) Corrigendum: Current insights into the regulation of programmed cell death by TP53 mutation in cancer. Front. Oncol. 12:1071831. doi: 10.3389/fonc.2022.1071831
Received
17 October 2022
Accepted
31 October 2022
Published
11 November 2022
Volume
12 - 2022
Edited and reviewed by
Jin Zhang, University of Mississippi Medical Center, United States
Updates
Copyright
© 2022 Su, Sai, Zhou, Liu, Du, Wu and Zhang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jinghua Wu, wujh@ncst.edu.cn; Jinghua Zhang, jhzhang_te@163.com
This article was submitted to Cancer Genetics, a section of the journal Frontiers in Oncology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.