Prostate cancer is the most widely diagnosed disease in men worldwide and is currently ranked as one of the top five cancers in both incidence and mortality. The disease represents significant challenges as prostate cancer has a low survival rate and poor prognosis. Therefore, studies are required to identify how imaging techniques, e.g. magnetic resonance imaging (MRI) can be utilized for early detection and to assess the evolution of metastasis during treatment.
The current Research Topic aims to generate a discussion on how imaging aids in the detection of prostate cancer and which impact it can have on survival. It contains four articles, two systematic reviews and two original articles.
The first review by Turpin et al. focuses on imaging in metastatic prostate cancers in general and its problem. It underlines the dilemma we have in daily practice. With Prostate-specific membrane antigen (PSMA)- positron emission tomography (PET) we have a novel imaging modality with better sensitivity and specificity compared to conventional imaging technologies. However, its availability is limited, and outcomes of most randomized trials still rely on conventional imaging. Next to a validation of novel imaging modalities, the authors highlight the importance of a better communication between clinicians and imagers.
The second systematic review and meta-analysis by Xie et al. compares the detection rates of prostate cancer with MRI/Transrectal Ultrasound Fusion-Guided Targeted Biopsy and Transrectal Ultrasound-Guided Systematic Biopsy. 26 studies could be included in the meta-analysis. The results clearly underline how crucial prostate MRI is in the diagnostic workout. Compared to systematic biopsies, MRI-targeted biopsy alone detects more clinically significant and more high-risk prostate cancer cases, and fewer clinically insignificant cases. MRI-targeted biopsy combined with systematic biopsy enhances the overall detection rate compared to either one of the biopsy techniques alone but does not reduce the detection rate of clinically insignificant disease.
The original work by Yang et al. aims to assess the association of radiomics features based on multiparametric MRI (mpMRI) with the proportion of intraductal carcinoma of prostate. Within a cohort of 97 men, the authors could demonstrate how radiomics can help to differentiate between low and high proportions of intraductal carcinoma and pure acinar adenocarcinoma. It gives us a hint what radiomics based on MRI information can do and how it might influence diagnostic and treatment decisions in future.
The last prospective study of this Research Topic by Reijnen et al. explores if a high-resolution diffusion weighted MRI sequence (DWI-only) could be used as a first step in an MRI-directed diagnostic pathway. The authors could demonstrate that with DWI-only, all patients diagnosed with clinically significant cancer were identified. These findings are important. Reducing the multiparametric MRI to an monoparametric, or a biparametric MRI, which is currently assessed in the Prostate Imaging Using MRI +/- Contrast Enhancement (PRIME) trial (NCT04571840), MRI costs as well as exam time could be significantly reduced and thus be available for more patients.
In summary, this Research Topic contains several high-quality articles, reviewing the current literature and raises new concepts and ideas related to the role of MRI and imaging in prostate cancer that can also be used as further insights for work in this field.
Statements
Author contributions
FP wrote the first draft of the manuscript. MM contributed to manuscript revision, read, and approved the submitted version.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
MRI, prostate cancer, radiomics, imaging, diagnosis
Citation
Preisser F and Marchioni M (2023) Editorial: Magnetic resonance imaging applications for the diagnosis of prostate cancer. Front. Oncol. 13:1191543. doi: 10.3389/fonc.2023.1191543
Received
22 March 2023
Accepted
22 March 2023
Published
04 April 2023
Volume
13 - 2023
Edited and reviewed by
Ronald M Bukowski, Cleveland Clinic, United States
Updates
Copyright
© 2023 Preisser and Marchioni.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Felix Preisser, f.preisser@uke.de
This article was submitted to Genitourinary Oncology, a section of the journal Frontiers in Oncology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.