In this Research Topic area of using elastography as a prognostic factor in cancers, five articles have been published. To show the robustness of the technique, these articles evaluate breast cancer, lymph node cancer, carotid body tumors, and colon cancer. A review of MRE for tumor diagnosis is also included in this topic area.
Most cancers are stiff. When treatments are working, the cancers become soft. This allows elastography to be an excellent biomarker for treatment response. Further work is needed to determine the amount of change in elasticity needed to confirm that a treatment is working over a short period of time. If that early response is not seen, the patient can be changed to another treatment regimen. The changes in elastography can predict a complete response, which also needs to be determined. These changes will probably be different for each type of cancer. Investigation of whether the percentage of the tumor that is changing stiffness early on is indicative of treatment response, size changes, or other additional features will improve the accuracy of treatment response. It is also important to note that some cancers such as lymphoma are not stiff, and it is unlikely that elastography will be able to predict treatment response in these patients.
Most other imaging for early treatment response requires injection of a contrast agent, and it is change in vascularity that is used to assess treatment response. The RECIST criteria have been used, but there is a delay in finding the changes that occur, and therefore, early response to treatment is usually not observed. Elastography is performed without contrast and therefore can be used in patients who cannot receive contrast. Also, ultrasound elastography is less expensive and can be performed at more time points if needed.
Further work in this area is needed to develop protocols for the use of elastography for treatment monitoring. Multicenter trials using these protocols are also needed for elastography to become an accepted method of treatment monitoring.
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Summary
Keywords
elastography, cancer, breast, tumor response, shear wave
Citation
Barr RG (2023) Editorial: Imaging elasticity as a tangible prognostic factor in cancers. Front. Oncol. 13:1211615. doi: 10.3389/fonc.2023.1211615
Received
25 April 2023
Accepted
10 May 2023
Published
21 June 2023
Volume
13 - 2023
Edited and reviewed by
Zaver Bhujwalla, Johns Hopkins University, United States
Updates
Copyright
© 2023 Barr.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Richard G. Barr, rgbarr525@gmail.com
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.