Abstract
Extracorporeal life support (ECLS) represents an essential component in the treatment of the pediatric patient with refractory heart failure. Defined as the use of an extracorporeal system to provide cardiopulmonary support, ECLS provides hemodynamic support to facilitate end-organ recovery and can be used as a salvage therapy during acute cardiorespiratory failure. Support strategies employed in pediatric cardiac patients include bridge to recovery, bridge to therapy, and bridge to transplant. Advances in extracorporeal technology and refinements in patient selection have allowed wider application of this therapy in pediatric heart failure patients.
Introduction
Based on John Gibbon’s pioneering work on the development of a heart–lung machine for cardiac surgery, Bartlett and his colleagues began using extracorporeal support for prolonged periods of time to support critically ill patients in the 1970s (1). The first pediatric cardiac extracorporeal life support (ECLS) survivor was a young child with postcardiotomy myocardial dysfunction following repair of transposition of the great arteries (2). Early clinical successes led to increased use of ECLS to support children with respiratory and cardiac failure. Data from the Extracorporeal Life Support Organization (ELSO) international registry indicate that ECLS has been used to provide cardiac support for more than 19,000 children (3). Despite significant advances in durable and non-durable ventricular assist devices for adult patients, ECLS remains the most commonly used form of mechanical cardiac and cardiopulmonary support in infants and young children.
Perioperative Support
Perioperative support following surgical intervention for congenital heart disease remains the most common indication (74%) for pediatric cardiac ECLS, followed by support for cardiomyopathy (4.4%), myocarditis (2.6%), cardiac arrest (2.5%), and cardiogenic shock (1.8%) (3). Not surprisingly, venoarterial ECLS is the most common mode of support for these patients (95%) (4). Overall survival in this patient population has increased moderately during the past several decades from 38% (1990–2000) to 45% (2001–2011) but remains less than survival in patients of similar age who require ECLS for respiratory support alone (5). Pediatric cardiac ECLS survival appears to be improving, despite the fact that ECLS is being used to support an increasingly heterogeneous patient population. Single-ventricle heart disease, once considered a contraindication for ECLS, now represents one of the most common diagnoses in neonates who require extracorporeal support (6). Increased utilization has also been observed in other unique patient populations during the past decade, including ECLS for refractory cardiac arrest (ECPR, over 4,000 cases in the ELSO registry) and patients being bridged to transplantation (284 cases reported in the ELSO registry) (3, 4).
Despite advances in perioperative care, myocardial protection, anesthesia, and surgical techniques, children remain at risk for myocardial dysfunction following heart surgery. In most cases, myocardial dysfunction is mild and improves with inotropic therapy, afterload reduction, and pulmonary vasodilators. In its most severe form, postoperative myocardial dysfunction may lead to inadequate end-organ oxygen delivery and inability to separate from cardiopulmonary bypass. ECLS may be used as short-term supportive therapy to improve end-organ oxygen delivery, reverse acidosis and other metabolic derangements, prevent progression to cardiac arrest, prevent dysrhythmias, and limit further myocardial injury by decreasing myocardial oxygen demand. Initiation of ECLS provides short-term mechanical circulatory support that enables weaning of inotropic and vasopressor support and facilitates myocardial recovery. The incidence of postoperative ECLS varies by patient population and center, with some centers reporting its use in fewer than 0.6% of patients and others reporting that up to 6.8% of patients require postoperative mechanical support (7, 8). Postoperative ECLS is utilized in as many as 10% of patients who undergo some high-risk procedures, such as surgical palliation of single-ventricle heart disease (9). Overall survival in children who require ECLS for failure to separate from cardiopulmonary bypass is around 45% (10).
Initiation of ECLS for failure to separate from cardiopulmonary bypass should prompt investigation for residual hemodynamically significant lesions. Diagnostic imaging, such as echocardiography or catheterization, should be undertaken promptly when questions remain about adequacy of surgical repair or palliation, or if a patient makes poor clinical progression toward separation from ECLS. Unsuspected lesions may have been found in over half of pediatric ECLS patients who undergo perioperative diagnostic cardiac catheterization (11). In many cases, clinically important residual lesions may be addressed by percutaneous interventional techniques, whereas others may require surgical intervention to facilitate separation from ECLS. Left ventricular distention must be avoided in patients who require postoperative venoarterial ECLS. Ventricular distention increases myocardial wall tension and reduces myocardial oxygen delivery, which has deleterious effects on ventricular recovery and function. In patients with severely depressed left ventricular systolic function, consideration should be given to inserting a left heart vent at time of conversion from cardiopulmonary bypass to ECLS. Effective left ventricle decompression may be accomplished by venting through pulmonary vein, left atrium, or left ventricle apex cannulae. Alternatively, surgical or percutaneous balloon atrial septostomy may be used to adequately decompress the left ventricle during ECLS. Meticulous hemostasis prior to leaving the operating room is essential to reduce the likelihood of postoperative bleeding and infection, which occur in up to 30 and 11%, respectively. Positive routine surveillance mediastinal cultures obtained at time of postoperative surgical interventions, including delayed sternal closure, have been shown to be predictive of postoperative surgical site infection in children (12). Routine ECLS circuit cultures may also detect occult but clinically important infection in pediatric patients who require postoperative ECLS.
Indications and thresholds for initiating ECLS during the perioperative period are not well established. There is evidence that patients who successfully separate from cardiopulmonary bypass but subsequently require ECLS during the postoperative period are more likely to survive than patients who are unable to separate form cardiopulmonary bypass (69 vs. 24% survival) (13). However, there is also evidence that initiation of ECLS in the operating room is associated with improved survival when compared to initiation of support in the intensive care unit (64 vs. 29%) (14). Irrespective of indication for and location of support, prolonged duration of ECLS is an independent risk factor for death. ECLS survival is typically >50% when support is limited to <72 h but is <40% for patients supported >72 h (15, 16). Survival following 7 days of ECLS support is very low in this population (17).
Bridge to Transplant
Extracorporeal life support may be used to support children with severe, life-threatening congenital and non-congenital forms of heart failure. The most common forms of non-congenital heart disease in this population are cardiomyopathy (16% of pediatric cardiac ECLS cases) and myocarditis (8% of cases) (4). In general, survival is better in these patients (62% cardiomyopathy; 70% myocarditis) than in those with structural congenital etiologies of heart failure because in many cases, the underlying disease process is self-limited or manageable with appropriate pharmacotherapy. Additional causes of pediatric heart failure that may require ECLS include refractory or chronic dysrhythmia, infection, and myocardial infarction (18, 19).
Despite increased risk associated with prolonged support, ECLS has been used to provide mechanical cardiac support for children awaiting heart transplantation for nearly 30 years (20–24). The ELSO registry contains data from over 280 pediatric patients who were successful bridged to cardiac transplantation using ECLS (4). Single-center reports of pediatric patients who receive ECLS while awaiting heart transplantation suggest that up to 24% of patients may recover adequate myocardial function to be weaned from ECLS prior to transplantation and that approximately 50% of patients are successfully transplanted (23, 24). Early posttransplant survival is approximately 80%, and survival in patients supported with ECLS appears to be similar to that in patients who do not requite extracorporeal bridge to transplantation at 1 year.
Retrospective analysis of ELSO and Organ Procurement Transplant Network data suggest that up to 45% of children awaiting heart transplantation while receiving ECLS may ultimately receive a donor organ, but only 47% of these patients survive to hospital discharge (25). In contrast, bridge to transplantation with the Berlin Heart EXCOR, the only pediatric ventricular assist device approved for use in the United States, is successful in 64% of patients (26). Approximately 75% of these patients remain alive at 12 months but roughly one-third of children supported with the Berlin Heart device experience clinically significant neurologic injury prior to transplantation (26). It is clear that ECLS and currently available ventricular assist devices are inferior to adult mechanical bridge to transplant options. Despite this, ECLS will likely continue to play a crucial role in stabilization of critically ill young children and, in many cases, will serve as a viable option for bridge-to-bridge or bridge-to-decision (27, 28). In addition, ECLS is probably the best mode of mechanical cardiac support for infants and young children with single-ventricle heart disease and refractory heart failure.
Extracorporeal Cardiopulmonary Resuscitation
Perhaps, the most significant advancement in the field of pediatric ECLS during the last several decades is the use of ECLS as an adjunct to standard cardiopulmonary resuscitation (ECPR). The earliest reported use of ECPR was in 1976 (29). Since that time, a number of advances in ECLS equipment, refinements in surgical techniques, and growing recognition of an apparent survival benefit have led to increased use of ECPR in pediatric patients. Hospitals worldwide have developed rapid-response ECPR programs to expeditiously initiate ECLS during cardiopulmonary resuscitation, often within 30 min of cardiac arrest (30). To date, over 6,400 ECPR cases have been reported to the ELSO registry, with an overall survival rate of 36.8% (3). Despite the absence of randomized, controlled trials to support the use of ECPR, there is strong evidence that ECPR provides a significant survival advantage over conventional cardiopulmonary resuscitation in children (37 vs. 13–27%) (31). Overall survival following ECPR appears to be higher for neonates (41%) and children (41%) than adults (30%), which may reflect age-related differences in etiology of cardiac arrest and patient comorbidities (3). ECPR survival is greater in children with two functional ventricles than in those who have single-ventricle congenital heart disease (32, 33). Survival is as high as 89% in children with cardiomyopathy who experience cardiac arrest (33). Overall ECPR survival is lower (21%) and central nervous system hemorrhage is higher in neonates born before 34-week gestational age than it is for all preterm infants (27% survival) (34).
There is no consensus regarding the impact of duration of pre-ECLS cardiopulmonary resuscitation on survival in children. Some retrospective studies suggest that duration of pre-ECPR resuscitation impacts survival (31). Although survival following conventional resuscitation efforts >30 min is rare, survival is not uncommon in patients who receive ECPR following 45–60 min of conventional resuscitation (30, 31, 35, 36), and the use of conventional resuscitative measures for >30 min before initiation of ECPR is not necessarily associated with poorer outcome (30). The impact of duration of pre-ECPR resuscitation on survival may vary by age and patient population. Increased duration of pre-ECPR resuscitation has been shown to be associated with worse outcome in adults, using propensity score-matched analysis (36). Adequacy, rather than duration, of pre-ECPR resuscitation is undoubtedly the most important determinant of ECPR outcomes (37–39).
Not surprisingly, patients who require ECPR are at risk for significant ECLS and resuscitation-related complications. Clinically significant hemorrhage is seen in as many as 30% of patients (32). Acute kidney injury that requires renal replacement therapy occurs in 8.7% and bloodstream infections in 8.5% of patients (32). Central nervous system injury occurs in approximately 11% of ECPR patients and is independently associated with increased mortality (34). Approximately 80% of pediatric ECPR survivors have a Pediatric Cerebral Performance Category score ≤2 at hospital discharge or follow-up, indicating mild or no neurological disability (30). Information about long-term neurologic outcome is limited, but a recent study reported that children who survived ECPR scored 76.5% on full-scale intelligence quotient testing 5 years after hospital discharge (40).
Despite increasing use by a growing number of centers, ECPR remains a relatively infrequently utilized therapy, representing only 8% of ECLS cases reported to the ELSO registry (3). When properly executed, ECPR requires expeditious mobilization of a large number of hospital resources and coordinated interaction between several interprofessional teams. Many centers now perform ECPR simulation training to increase team preparedness and reduce time to ECLS initiation. ECLR simulation has been found to improve practitioner confidence and knowledge regarding deployment of ECPR (41, 42) and reduce ECLS initiation times during ECPR events (43). ECLS simulation is recognized as a critical component in the development and maintenance of successful ECPR programs.
Contraindications
Pediatric cardiac ECLS is performed in a heterogeneous patient population that in many cases would not survive without extracorporeal support. Therefore, it is difficult to determine absolute contraindications for its use. In general, potential ECLS candidates must be free of a lethal cardiac condition not amenable to surgery or any other terminal condition, including a severe and irreversible brain injury. The ECLS team must assess each candidate for bleeding risk, and those with severe bleeding diatheses are generally not offered ECLS. Historically, extreme prematurity and low weight have been considered contraindications; however, determining absolute cutoffs for gestational age or weight has proven difficult. Extrapolating data from neonatal respiratory ECLS, Smith et al. showed that neonates with gestational age <32 weeks had a 38% rate of CNS hemorrhage (44). In this report of ELSO data, there was a stepwise decrease in mortality as gestational age increased. Furthermore, McMullan et al. showed that survival following neonatal ECPR decreased with younger gestational age (34).
Several reports have addressed the association between patient weight and pediatric cardiac ECLS outcome. For example, infants placed on ECLS weighing <2.5 kg with hypoplastic left heart syndrome have been found to have a survival of only 10% (45). A follow-up study examined outcomes in neonates <3 kg placed on ECLS following cardiac surgery (46). In this series, 30-day survival was 33%. Finally, neonates <2 kg that underwent ECPR were found to have a greater than four times risk of mortality as compared to newborns >3 kg (34). The ELSO registry contains very little data on patients at the extreme lower end of gestational age or weight, making the determination of absolute cutoff values for gestational age or weight impossible. Therefore, clinicians must balance risks and potential benefits on an individual patient basis, understanding the risk of neurologic injury and death increases in smaller and younger infants.
Complications
Hemorrhagic
Children who require ECLS are at risk for a number of clinically significant and life-threatening complications. Postoperative hemorrhage is an important risk factor for mortality in children who require ECLS during the postoperative period (47). Hemorrhagic complications, including surgical and cannulation site bleeding, occur in >30% of patient populations, such as patients who require perioperative support (3). Cardiopulmonary bypass causes platelet dysfunction due to contact activation and consumption of platelets and clotting factors, which increases the risk of hemorrhage (48). In addition, cardiopulmonary bypass-induced hemodilution further increases the risk of postoperative bleeding (49). ECLS circuit surface coatings are frequently used to reduce the risk of circuit-related derangements in the coagulation system, but there is little clinical evidence to support the use of surface coatings or for the superiority of one coating over another. Immaturity of the coagulation cascade makes neonates particularly vulnerable to ECLS-related hemorrhage during the postoperative period (50). The impact of ECLS-related bleeding on survival appears to vary by age, with neonates exhibiting worse overall survival (31%) than older children (50%). Patients at increased risk for bleeding may be safely managed with reduced or delayed systemic anticoagulation for a limited period of time (51). In cases of refractory hemorrhage, recombinant Factor VII can been used to effectively control bleeding in many patients, albeit with a 19–24% rate of thromboembolic complications (52–55).
CNS Injury
Central nervous injury is also a relatively common and devastating complication for pediatric cardiac ECLS patients. CNS injury represents a heterogenous group of disorders that include CNS hemorrhage, ischemic stroke, seizures, and anoxic brain injury. Neonates, especially premature infants, are at greatest risk (11%) for experiencing central nervous system hemorrhage (3). The need for anticoagulation, along with the presence of an arterial cannula (during venoarterial ECLS), places these patients at increased risk for both thrombotic and hemorrhagic CNS complications. Other risk factors for severe CNS injury in pediatric ECLS patients include metabolic acidosis, inotropic/vasopressor medication usage, renal failure, cardiopulmonary resuscitation, or LVAD placement prior to ECLS initiation (56). Pediatric cardiac ECLS patients have also been found to have higher rates of CNS hemorrhage as compared to medical patients, and CNS hemorrhage has been shown to significantly increase mortality (47). A recent ELSO report reviewed cannulation trends and neurologic complications and found that pediatric patients placed on venoarterial ECLS have been found to be 1.6 times more likely to suffer CNS injury than those placed on venovenous support; interestingly, no difference was observed in rates of neurologic complications between carotid and femoral cannulation among venoarterial patients (57). Seizures are a relatively common manifestation of CNS injury in pediatric ECLS patients and portend a poor outcome. Seizure activity can be difficult to detect in these patients, as most are sedate and/or chemically paralyzed. However, the utility of routine use of monitoring to detect seizure activity, using electroencephalograms (EEGs) or amplitude-integrated EEG, remains controversial and an area of active investigation (58, 59).
Other Complications
Additional complications include oxygenator failure, pericardial tamponade, pneumothorax, acidosis, seizures, infection, renal failure, and limb ischemia. Renal failure is an independent predictor of mortality in several ECLS patient populations (32, 34). Acute renal failure (GFR <35 ml/min/1.73 m) is relatively common and has been reported in up to 72% of pediatric cardiac ECLS patients with 59% requiring continuous renal replacement therapy (CRRT) (60). Risk factors for renal failure in pediatric ECLS patients include increased duration of extracorporeal support, hemolysis, increased pre-ECLS creatinine level, and pre-ECLS acidosis (60, 61). Severity of pre-ECLS acidemia is associated with reduced survival in neonates who require ECLS, suggesting that earlier initiation of ECLS may reduce the degree and duration of inadequate oxygen delivery and improve survival in these patients (62).
Summary
The field of pediatric ECLS has experienced remarkable technological and medical advances that have led to wider acceptance and broader applications of this lifesaving therapy during recent decades. The origins of contemporary ECLS are based on the pioneering work of John Gibbon in 1931, when he wrote “the idea naturally occurred to me that if it were possible to remove continuously some of the blue blood from the patient’s swollen veins, put oxygen into that blood and allow carbon dioxide to escape from it, and then inject continuously the now-red blood into the patient’s arteries, we might have saved her life” (2). Nearly 90 years later, his vision has been realized. Continuous improvements in circuit design, individualized anticoagulation strategies, and recognition of the importance of ECLS in the management of pediatric heart failure will undoubtedly lead to increased use of this highly complex but efficacious support therapy.
Statements
Author contributions
CB – conception of manuscript, literature review, manuscript preparation, and final revisions. DM – conception of manuscript, critical manuscript revisions, and final revisions.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1
BartlettRHGazzanigaABFongSWJefferiesMRRoohkHVHaiducN. Extracorporeal membrane oxygenator support for cardiopulmonary failure. Experience in 28 cases. J Thorac Cardiovasc Surg (1977) 73(3):375–86.
2
BartlettRH. John H Gibbon Jr Lecture. Extracorporeal life support: Gibbon fulfilled. J Am Coll Surg (2014) 218(3):317–27.10.1016/j.jamcollsurg.2013.12.002
3
ELSO. 2016 ELSO International Summary. Ann Arbor, MI: Extracorporeal Life Support Organization Registry (2016). p. 1–26.
4
PadenMLRycusPTThiagarajanRRRegistryE. Update and outcomes in extracorporeal life support. Semin Perinatol (2014) 38(2):65–70.10.1053/j.semperi.2013.11.002
5
PadenMLConradSARycusPTThiagarajanRRRegistryE. Extracorporeal Life Support Organization registry report 2012. ASAIO J (2013) 59(3):202–10.10.1097/MAT.0b013e3182904a52
6
MesherALMcMullanDM. Extracorporeal life support for the neonatal cardiac patient: outcomes and new directions. Semin Perinatol (2014) 38(2):97–103.10.1053/j.semperi.2013.11.006
7
UndarAMcKenzieEDMcGarryMCOwensWRSurpriseDLKilpackVDet alOutcomes of congenital heart surgery patients after extracorporeal life support at Texas Children’s Hospital. Artif Organs (2004) 28(10):963–6.10.1111/j.1525-1594.2004.07378.x
8
DerbyCDKolczJKerinsPJDuncanDRQuezadaEPizarroC. Aristotle score predicts outcome in patients requiring extracorporeal circulatory support following repair of congenital heart disease. ASAIO J (2007) 53(1):82–6.10.1097/01.mat.0000248230.47551.6c
9
OhyeRGSleeperLAMahonyLNewburgerJWPearsonGDLuMet alComparison of shunt types in the Norwood procedure for single-ventricle lesions. N Engl J Med (2010) 362(21):1980–92.10.1056/NEJMoa0912461
10
SasakiTAsouTTakedaYOnakatomiYTominagaTYamamotoY. Extracorporeal life support after cardiac surgery in children: outcomes from a single institution. Artif Organs (2014) 38(1):34–40.10.1111/aor.12191
11
CallahanRTruccoSMWeardenPDBeermanLBAroraGKreutzerJ. Outcomes of pediatric patients undergoing cardiac catheterization while on extracorporeal membrane oxygenation. Pediatr Cardiol (2015) 36(3):625–32.10.1007/s00246-014-1057-5
12
AdlerALSmithJPermutLCMcMullanDMZerrDM. Significance of positive mediastinal cultures in pediatric cardiovascular surgical procedure patients undergoing delayed sternal closure. Ann Thorac Surg (2014) 98(2):685–90.10.1016/j.athoracsur.2014.03.038
13
WaltersHLHakimiMRiceMDLyonsJMWhittleseyGCKleinMD. Pediatric cardiac surgical ECMO: multivariate analysis of risk factors for hospital death. Ann Thorac Surg (1995) 60(2):329–36; discussion 336–7.10.1016/0003-4975(95)00410-M
14
ChaturvediRRMacraeDBrownKLSchindlerMSmithECDavisKBet alCardiac ECMO for biventricular hearts after paediatric open heart surgery. Heart (2004) 90(5):545–51.10.1136/hrt.2002.003509
15
AharonASDrinkwaterDCChurchwellKBQuislingSVReddyVSTaylorMet alExtracorporeal membrane oxygenation in children after repair of congenital cardiac lesions. Ann Thorac Surg (2001) 72(6):2095–101; discussion 2101–2.10.1016/S0003-4975(01)03209-X
16
AlsoufiBAl-RadiOOGruenwaldCLeanLWilliamsWGMcCrindleBWet alExtra-corporeal life support following cardiac surgery in children: analysis of risk factors and survival in a single institution. Eur J Cardiothorac Surg (2009) 35(6):1004–11; discussion 1011.10.1016/j.ejcts.2009.02.015
17
SherwinEDGauvreauKScheurerMARycusPTSalvinJWAlmodovarMCet alExtracorporeal membrane oxygenation after stage 1 palliation for hypoplastic left heart syndrome. J Thorac Cardiovasc Surg (2012) 144(6):1337–43.10.1016/j.jtcvs.2012.03.035
18
SivarajanVBAlmodovarMCRodefeldMDLaussenPC. Pediatric extracorporeal life support in specialized situations. Pediatr Crit Care Med (2013) 14(5 Suppl 1):S51–61.10.1097/PCC.0b013e318292e16e
19
SalernoJCSeslarSPChunTUVafaeezadehMParrishARPermutLCet alPredictors of ECMO support in infants with tachycardia-induced cardiomyopathy. Pediatr Cardiol (2011) 32(6):754–8.10.1007/s00246-011-9961-4
20
FrazierEAFaulknerSCSeibPMHarrellJEVan DevanterSHFasulesJW. Prolonged extracorporeal life support for bridging to transplant: technical and mechanical considerations. Perfusion (1997) 12(2):93–8.10.1177/026765919701200203
21
FiserWPYetmanATGunselmanRJFasulesJWBakerLLChipmanCWet alPediatric arteriovenous extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation. J Heart Lung Transplant (2003) 22(7):770–7.10.1016/S1053-2498(02)00808-2
22
DaltonHJSiewersRDFuhrmanBPDel NidoPThompsonAEShaverMGet alExtracorporeal membrane oxygenation for cardiac rescue in children with severe myocardial dysfunction. Crit Care Med (1993) 21(7):1020–8.10.1097/00003246-199307000-00016
23
KirshbomPMBridgesNDMyungRJGaynorJWClarkBJSprayTL. Use of extracorporeal membrane oxygenation in pediatric thoracic organ transplantation. J Thorac Cardiovasc Surg (2002) 123(1):130–6.10.1067/mtc.2002.118504
24
GajarskiRJMoscaRSOhyeRGBoveELCrowleyDCCusterJRet alUse of extracorporeal life support as a bridge to pediatric cardiac transplantation. J Heart Lung Transplant (2003) 22(1):28–34.10.1016/S1053-2498(02)00476-X
25
AlmondCSSinghTPGauvreauKPierceyGEFynn-ThompsonFRycusPTet alExtracorporeal membrane oxygenation for bridge to heart transplantation among children in the United States: analysis of data from the Organ Procurement and Transplant Network and Extracorporeal Life Support Organization Registry. Circulation (2011) 123(25):2975–84.10.1161/CIRCULATIONAHA.110.991505
26
AlmondCSMoralesDLBlackstoneEHTurrentineMWImamuraMMassicotteMPet alBerlin Heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US children. Circulation (2013) 127(16):1702–11.10.1161/CIRCULATIONAHA.112.000685
27
LebretonGPozziMMastroianniCLégerPPavieALeprinceP. Extracorporeal life support as a bridge to bridge: a strategy to optimize ventricular assist device results. Eur J Cardiothorac Surg (2015) 48(5):785–91.10.1093/ejcts/ezu516
28
MarascoSFLoCMurphyDSummerhayesRQuayleMZimmetAet alExtracorporeal life support bridge to ventricular assist device: the double bridge strategy. Artif Organs (2016) 40(1):100–6.10.1111/aor.12496
29
MattoxKLBeallAC. Resuscitation of the moribund patient using portable cardiopulmonary bypass. Ann Thorac Surg (1976) 22(5):436–42.10.1016/S0003-4975(10)64452-9
30
KaneDAThiagarajanRRWypijDScheurerMAFynn-ThompsonFEmaniSet alRapid-response extracorporeal membrane oxygenation to support cardiopulmonary resuscitation in children with cardiac disease. Circulation (2010) 122(11 Suppl):S241–8.10.1161/CIRCULATIONAHA.109.928390
31
SivarajanVBBestDBrizardCPShekerdemianLSd’UdekemYButtW. Duration of resuscitation prior to rescue extracorporeal membrane oxygenation impacts outcome in children with heart disease. Intensive Care Med (2011) 37(5):853–60.10.1007/s00134-011-2168-6
32
ChanTThiagarajanRRFrankDBrattonSL. Survival after extracorporeal cardiopulmonary resuscitation in infants and children with heart disease. J Thorac Cardiovasc Surg (2008) 136(4):984–92.10.1016/j.jtcvs.2008.03.007
33
WolfMJKanterKRKirshbomPMKogonBEWagonerSF. Extracorporeal cardiopulmonary resuscitation for pediatric cardiac patients. Ann Thorac Surg (2012) 94(3):874–9; discussion 879–80.10.1016/j.athoracsur.2012.04.040
34
McMullanDMThiagarajanRSmithKRycusPBroganT. Extracorporeal cardiopulmonary resuscitation outcomes in term and premature neonates. Pediatr Crit Care Med (2014) 15(1):e9–16.10.1097/PCC.0b013e3182a553f3
35
GoldbergerZDChanPSBergRAKronickSLCookeCRLuMet alDuration of resuscitation efforts and survival after in-hospital cardiac arrest: an observational study. Lancet (2012) 380(9852):1473–81.10.1016/S0140-6736(12)60862-9
36
ChenYSLinJWYuHYKoWJJerngJSChangWTet alCardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis. Lancet (2008) 372(9638):554–61.10.1016/S0140-6736(08)60958-7
37
ChaiPJJacobsJPDaltonHJCostelloJMCooperDSKirschRet alExtracorporeal cardiopulmonary resuscitation for post-operative cardiac arrest: indications, techniques, controversies, and early results – what is known (and unknown). Cardiol Young (2011) 21(Suppl 2):109–17.10.1017/S1047951111001685
38
StiellIGBrownSPNicholGCheskesSVaillancourtCCallawayCWet alWhat is the optimal chest compression depth during out-of-hospital cardiac arrest resuscitation of adult patients?Circulation (2014) 130(22):1962–70.10.1161/CIRCULATIONAHA.114.008671
39
NicholGLerouxBWangHCallawayCWSopkoGWeisfeldtMet alTrial of continuous or interrupted chest compressions during CPR. N Engl J Med (2015) 373(23):2203–14.10.1056/NEJMoa1509139
40
Garcia GuerraGZorzelaLRobertsonCMAltonGYJoffeARMoezEKet alSurvival and neurocognitive outcomes in pediatric extracorporeal-cardiopulmonary resuscitation. Resuscitation (2015) 96:208–13.10.1016/j.resuscitation.2015.07.034
41
Sanchez-GlanvilleCBrindleMESpenceTBlackwoodJDrewsTMenziesSet alEvaluating the introduction of extracorporeal life support technology to a tertiary-care pediatric institution: smoothing the learning curve through interprofessional simulation training. J Pediatr Surg (2015) 50(5):798–804.10.1016/j.jpedsurg.2015.02.037
42
BrumRRajaniRGelandtEMorganLRaguseelanNButtSet alSimulation training for extracorporeal membrane oxygenation. Ann Card Anaesth (2015) 18(2):185–90.10.4103/0971-9784.154472
43
SuLSpaederMCJonesMBSinhaPNathDSJainPNet alImplementation of an extracorporeal cardiopulmonary resuscitation simulation program reduces extracorporeal cardiopulmonary resuscitation times in real patients. Pediatr Crit Care Med (2014) 15(9):856–60.10.1097/PCC.0000000000000234
44
SmithKMMcMullanDMBrattonSLRycusPKinsellaJPBroganTV. Is age at initiation of extracorporeal life support associated with mortality and intraventricular hemorrhage in neonates with respiratory failure?J Perinatol (2014) 34(5):386–91.10.1038/jp.2013.156
45
GelehrterSFiferCGArmstrongAHirschJGajarskiR. Outcomes of hypoplastic left heart syndrome in low-birth-weight patients. Pediatr Cardiol (2011) 32(8):1175–81.10.1007/s00246-011-0053-2
46
BhatPHirschJCGelehrterSCooleyEDonohueJKingKet alOutcomes of infants weighing three kilograms or less requiring extracorporeal membrane oxygenation after cardiac surgery. Ann Thorac Surg (2013) 95(2):656–61.10.1016/j.athoracsur.2012.06.041
47
WerhoDKPasqualiSKYuSDonohueJAnnichGMThiagarajanRRet alHemorrhagic complications in pediatric cardiac patients on extracorporeal membrane oxygenation: an analysis of the Extracorporeal Life Support Organization Registry. Pediatr Crit Care Med (2015) 16(3):276–88.10.1097/PCC.0000000000000345
48
DespotisGJAvidanMSHogueCW. Mechanisms and attenuation of hemostatic activation during extracorporeal circulation. Ann Thorac Surg (2001) 72(5):S1821–31.10.1016/S0003-4975(01)03211-8
49
KernFHMoranaNJSearsJJHickeyPR. Coagulation defects in neonates during cardiopulmonary bypass. Ann Thorac Surg (1992) 54(3):541–6.10.1016/0003-4975(92)90451-9
50
AndrewMPaesBMilnerRJohnstonMMitchellLTollefsenDMet alDevelopment of the human coagulation system in the full-term infant. Blood (1987) 70(1):165–72.
51
McMullanDMEmmertJPermutLMazorRJeffriesHParrishAet alMinimizing bleeding associated with mechanical circulatory support following pediatric heart surgery. Eur J Cardiothorac Surg (2011) 39(3):392–7.10.1016/j.ejcts.2010.07.027
52
WarrenOJRogersPLWatretALde WitKLDarziAWGillRet alDefining the role of recombinant activated factor VII in pediatric cardiac surgery: where should we go from here?Pediatr Crit Care Med (2009) 10(5):572–82.10.1097/PCC.0b013e3181a642d5
53
NieblerRAPunzalanRCMarchanMLankiewiczMW. Activated recombinant factor VII for refractory bleeding during extracorporeal membrane oxygenation. Pediatr Crit Care Med (2010) 11(1):98–102.10.1097/PCC.0b013e3181b0620b
54
McQuiltenZKBarnesCZattaAPhillipsLECommitteeHRS. Off-label use of recombinant factor VIIa in pediatric patients. Pediatrics (2012) 129(6):e1533–40.10.1542/peds.2011-2561
55
McMullanDM. Relative risks of recombinant factor VII. Pediatr Crit Care Med (2009) 10(5):604–5.10.1097/PCC.0b013e3181ae49e1
56
MehtaAIbsenLM. Neurologic complications and neurodevelopmental outcome with extracorporeal life support. World J Crit Care Med (2013) 2(4):40–7.10.5492/wjccm.v2.i4.40
57
RollinsMDHubbardAZabrockiLBarnhartDCBrattonSL. Extracorporeal membrane oxygenation cannulation trends for pediatric respiratory failure and central nervous system injury. J Pediatr Surg (2012) 47:68–75.10.1016/j.jpedsurg.2011.10.017
58
BennetKS. Brain monitoring during extracorporeal membrane oxygenation: will it alter care?Ped Crit Care Med (2013) 14(6):648–9.10.1097/PCC.0b013e3182975663
59
PappasAShankaranSStockmannPTBaraR. Changes in amplitude-integrated electroenchephalography in neonates treated with extracorporeal membrane oxygenation: a pilot study. J Pediatr (2006) 148(1):125–7.10.1016/j.jpeds.2005.07.044
60
SmithAHHardisonDCWordenCRFlemingGMTaylorMB. Acute renal failure during extracorporeal support in the pediatric cardiac patient. ASAIO (2009) 55(4):412–6.10.1097/MAT.0b013e31819ca3d0
61
LvLLongCLiuJHeiFJiBYuKet alPredictors of acute renal failure during extracorporeal membrane oxygenation in pediatric patients after cardiac surgery. Artif Organs (2016) 40(5):e79–83.10.1111/aor.12644
62
FordMGauvreauKMcMullanDAlmodovarMCooperDRycusPet alFactors associated with mortality amongst neonates requiring extracorporeal membrane oxygenation for cardiac disease. Analysis of data from the Extracorporeal Life Support Organization registry. Pediatr Crit Care Med (2016) 17(9):860–70.10.1097/PCC.0000000000000842
Summary
Keywords
extracorporeal life support, pediatrics, critical care, heart failure, congenital heart disease
Citation
Burke CR and McMullan DM (2016) Extracorporeal Life Support for Pediatric Heart Failure. Front. Pediatr. 4:115. doi: 10.3389/fped.2016.00115
Received
20 June 2016
Accepted
05 October 2016
Published
20 October 2016
Volume
4 - 2016
Edited by
Oswin Grollmuss, University of Paris-Sud, France
Reviewed by
Federico Gutierrez-Larraya, Hospital Universitario La Paz, Spain; Madhusudan Ganigara, Mt Sinai Medical Centre, USA; Muhammad Ali Mumtaz, Baylor College of Medicine, USA
Updates
Copyright
© 2016 Burke and McMullan.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: D. Michael McMullan, michael.mcmullan@seattlechildrens.org
Specialty section: This article was submitted to Pediatric Cardiology, a section of the journal Frontiers in Pediatrics
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.