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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Public Health | doi: 10.3389/fpubh.2019.00315

Effects of CYP3A4 polymorphisms on drug addiction risk among the Chinese Han population

li wang1, mei bai1, tianbo jin1, Jianwen Zheng1, Yuhe Wang1, Yongjun He1, Dongya Yuan1 and  Xue He1*
  • 1Xizang Minzu University, China

Background: Cytochrome P450 3A4 (CYP3A4) regulate pharmacokinetic and pharmcodynamic interactions during the process of drug absorption and metabolism, it suggests that CYP3A4 plays an important role in drug addiction. However, the association between CYP3A4 polymorphisms and drug addiction risk is still not clear.
Methods: This case-control study included 504 drug addicts and 501 healthy controls from place, China. Four single nucleotide polymorphisms (SNPs) in CYP3A4 (rs3735451, rs4646440, rs35564277 and rs4646437) were selected and genotyped by Agena MassARRAY platform. After adjusting by age and gender, we calculated odd ratios (OR) and 95%confidence intervals (CI) by logistic regression to estimate the association between CYP3A4 polymorphisms and drug addiction risk.
Results: We found rs4646440 and rs4646437 were associated with decreased risk of drug addiction in codominant (rs4646440: OR = 0.41, 95%CI = 0.19-0.92, p = 0.030; rs4646437: OR = 0.19, 95%CI = 0.04-0.87, p = 0.032) and recessive (rs4646440: OR = 0.41, 95%CI = 0.19-0.91, p = 0.028; rs4646437: OR = 0.20, 95%CI = 0.04-0.90, p = 0.036) models. Among the individuals aged ≤ 48 and men, rs3735451 and rs4646440 had strong relationship with decreased risk of drug addiction (p < 0.05). The effects of rs3735451 on drug addiction risk were related to drug-using time (p < 0.05). And, rs4646437 was related to drug addiction risk in the subgroup of age > 48 (p < 0.05) and man (p < 0.05). We also observed one block (rs4646440 and rs35564277) in haplotype analysis.
Conclusion: CYP3A4 polymorphisms were associated with drug addiction risk among the Chinese Han population.

Keywords: CYP3A4, drug addiction, case-control study, polymorphisms, Genetics

Received: 13 Aug 2019; Accepted: 14 Oct 2019.

Copyright: © 2019 wang, bai, jin, Zheng, Wang, He, Yuan and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Xue He, Xizang Minzu University, Xianyang, Shaanxi Province, China, hexue0621@163.com