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Original Research ARTICLE

Front. Public Health, 29 July 2020 |

Seniors' Physical Activity in Neighborhood Parks and Park Design Characteristics

Yujia Zhai1, Dongying Li2, De Wang1 and Cheng Shi1*
  • 1College of Architecture and Urban Planning, Tongji University, Shanghai, China
  • 2Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A&M University, College Station, TX, United States

Physical activity brings multiple health benefits to seniors. Neighborhood parks provide seniors with accessible spaces and opportunities to engage in physical activity. This study investigated the associations between neighborhood park design characteristics and seniors' total walking step and energy expenditure during the park visit. Seniors' total step was measured by pedometer, and energy expenditure was calculated based on self-reported activities in the park. The study was conducted in 15 neighborhood parks with an area <10 ha, and included 234 senior participants. One-way ANOVA analyses indicated that seniors in parks with larger surface area, longer trail, larger natural area and outdoor fitness equipment had taken more steps. While seniors in parks without water expended more energy. For instance, seniors in parks with surface areas <3 ha walked 507 fewer steps than seniors in parks with areas between 3 and 5 ha, and 691 fewer steps than those in parks larger than 5 ha. When including seniors' demographic attributes, multiple regression analyses suggested that total step was negatively associated with age, but positively associated with total natural area in the park and the presence of outdoor fitness equipment. Seniors energy expenditure was positively associated with BMI and the presence of outdoor fitness equipment. Energy expenditure was also related to income. These findings provide direct implications for neighborhood park design and management. Planners and designers can include more natural areas over paved areas, create longer trails and place more outdoor fitness equipment in parks to encourage seniors to walk and spend more energy.


Physical inactivity increases the risk of various chronic diseases, e.g., diabetes, cerebrovascular diseases, and obesity, which represent leading causes of death in the senior population. Conversely, appropriate levels of activity provide multiple benefits to seniors' physical and mental health (1, 2). Despite these facts, it is challenging to encourage seniors to stay physically active. Providing a safe, barrier-free, and healthy built environment for activities is critical to encouraging seniors' physical activity.

Urban parks are outdoor environments that facilitate physical activity for all ages (36), and they are also where seniors usually choose to engage in physical activity (7). Seniors prefer natural environments than built environments more than other adults (8, 9). Seniors tend to be physically active during park visits, and spend half their time walking (10). Existing research indicates that seniors prefer neighborhood park without nuisance, with many trees and plants (11). However, the characteristics of seniors' physical activity in urban parks have not been thoroughly explored, and their needs in the urban park are not well understood (4, 1214).

Existing research has examined the relationship between parks and physical activity from two directions. The first is how park characteristics relate to residents' overall physical activity at the neighborhood level, such as the amount of moderate and vigorous physical activity of residents in 1 week (3), and whether residents achieve recommended levels of activity (15). Important park characteristics that encourage physical activity at the neighborhood level are: more parks and green space (16), larger park size (6), more features in the park (17), and proximity of residents to parks (3, 4). These findings support the inclusion of more green space and park facilities in community planning and policy-making. The second perspective is how different park activity zones encourage moderate and vigorous physical activity at the activity zone level, such as the numbers of individuals engaging in moderate and vigorous activities on park pathways or in open spaces (18). Trails have the strongest relationship with park use for walking and other physical activities (17, 19, 20). However, considering activity at the zone level does not allow researchers to capture an individual's total physical activity in the park. It is important to understand how park characteristics may influence physical activity at the level of individual visitors. Without this information, urban designers and green space managers lack key guidance on how to design a neighborhood park to maximize its health benefits.

Another potential limitation of existing studies is the methods by which physical activity is captured. Widely-used methods include self-reported activity and on-site observation. The self-reported approach asks participants to record their physical activity during a period, such as whether they visited the park for physical activity and which specific park facilities they used (17), and the duration of physical activity (2123). However, these methods are susceptible to recall bias and may not accurately represent actual activity levels (5, 24). On-site observation tools, such as the System for Observing Play and Recreation in Communities (SOPARC), can be used to examine differences in physical activity level between various park activity zones (25, 26). Using this tool, researchers scan the whole activity zone at sampling moments and count the numbers of visitors engaging in physical activities with different intensities. However, scanning may not be effective in heavily-used urban parks full of people, and accurate recording is often costly and time-consuming (5). Therefore, objective approaches that can efficiently collect data on park users' physical activity are needed (5, 21). Equipment such as pedometers and accelerometers have been used to measure the intensity of physical activity (5, 27, 28), but few studies have employed them to examine physical activity in urban parks.

Furthermore, few studies have addressed how park characteristics may impact physical activity from a design perspective (29). Designers are interested in knowing how many paved open spaces should be provided, how the trails should be distributed, and how large natural areas such as lawns and groves should be. However, existing findings may only suggest the presence of trail that would facilitate physical activity, rather than addressing design characteristics of these features, thus may have limited implications for park design. Therefore studies that can bear design implications and inform design practices are needed (5, 26, 30, 31).

This study aims to address the above-mentioned knowledge gaps by examining how neighborhood park design characteristics relate to seniors' walking and energy expenditure on park visit at the individual level. We used pedometers to measure seniors' total steps taken during their park visits and estimated energy expenditure based on their recall of the activities they engaged in. This study can provide empirical evidence on how neighborhood park design attributes may relate to the physical activity of seniors in parks as well as providing an approach for collecting physical activity data. Moreover, the research findings can inform future urban park design and management to promote physical activity in seniors.


Study Sites

Neighborhood parks provide seniors with accessible outdoor spaces to engage in physical activities. Fifteen neighborhood parks in the city of Shanghai were selected as study sites (Table 1, Figure 1). Shanghai is the second-largest city in China, with an area of ~6,300 km2 and a population of 24 million people at the end of 2016 (33). Its population density is very high, with 18,000 to 32,000 residents per km2 in the central districts (33). Three main ring-shaped roads (the inner ring, the middle ring and the outer ring) divide Shanghai into four parts, and the 6th National Census of Population shows that population density decreases from the area within the inner ring to the area beyond the outer ring (34). The city has 165 urban parks with a total area of 24 km2 (32). Due to limited land availability, most urban parks in Shanghai have a small surface area (35); around half of them are <5 ha (36). Fifteen neighborhood parks with surface areas of between 3 ha and 10 ha were selected as study sites based on the following criteria: 1. the park administrators approved data collection; 2. detailed digital survey documents of the park were obtainable; and 3. the park served the general public and was open to all. The 15 neighborhood parks all have common activity zones, such as lawns, trails, and paved open spaces (Figure 2). All parks are either within or very close to the middle ring and are frequently used by the citizens. Annual visitor numbers from 2015 for the selected parks ranged from 186,016 to 12,157,350.


Table 1. Selected urban parks.


Figure 1. Locations of the 15 neighborhood parks in Shanghai.


Figure 2. Master Plans of the 15 neighborhood parks. [Figure credit: authors; an adapted version of figure has been published in article that belong to the same project (13).]


The study was conducted on sunny or cloudy weekdays during 3 weeks in October of 2017, when the weather in Shanghai is conducive to outdoor activities. Sampling days consisted of two data collection sessions, one in the morning (9:00 am−12:00 pm) and one in the afternoon (1:00 pm−5:00 pm). Researchers were stationed at the most frequently-used park entrance and invited seniors entering the park to voluntarily participate in the study. Three criteria were used in screening participants: 1. The participant should be aged 60 and above, 2. The participant did not need walking aids, and 3. The participant planned to visit the park, rather than pass through. Once a senior park user agreed to participate in the study, he or she was asked to sign a consent form and provided with the researcher's telephone number. The participant's telephone number was also recorded with their approval.

When distributing pedometers, the researcher turned on the pedometer and made sure it had been reset, and helped the participant put it around their neck or on their waist, where pedometer has a high reliability (37). We also instructed the participant not to touch the buttons on pedometers to prevent them from turning it off or resetting the record by accident. When pedometers were returned, the researcher recorded the total steps measured, as well as the time of return in order to discriminate step data from different participants. At the time of return, participants were invited to complete a questionnaire addressing their demographic information, daily park use patterns, and physical activities in the park. We asked participants to recall and report in chronological order each activity they engaged in and the duration of each activity.


Total Steps and Energy Expenditure in Parks

The physical activity of senior park users was assessed using the total steps measured by pedometer and by self-reported energy expenditure. The pedometer used in this study was the Yamax Power Walker EX-510 (Yamax Corp., Tokyo, Japan), which showed a high accuracy in counting steps (37). Existing research has proven the validity of pedometer in measuring physical activity (27, 28). In particular, the Yamax pedometer has been shown to be very accurate in recording steps and distance (38), and in counting the steps of seniors who neither uses walking aids nor walk very slow (39). Specifically, when walking speed is >0.83 m/s, its step counts have acceptable error rates (40). Typically, seniors aged 60 and above have a walking speed >1 m/s (41), thus it is appropriate to measure their steps with a pedometer.

Energy expenditure was calculated based on participants' reported activity types and durations. Using the Compendium for Physical Activities, we identified the metabolic equivalent (MET) intensity level for each type of activity reported by participants. The MET is a standardized measure of activity intensity defined as the ratio of work to resting metabolic rate. For example, walking is estimated as 3 METs and running is considered to be 6 METs. We calculated the energy expenditure of each participant for each activity by multiplying their weight (kg), the energy cost (METs) of a given physical activity (kcal·kg−1·h−1), and the duration of the physical activity (h).

Park Design Characteristics

We measured seven park design characteristics: 1. Park area, 2. Total trail length, 3. Total paved activity zone area, 4. Total natural area, 5. Presence of water, 6. Presence of outdoor fitness equipment, and 7. Presence of court (Figure 3). Table 2 provides the definition, justification, type, and data source for these design characteristics. We hypothesized that parks with larger areas, more trails, larger paved activity zone area, larger natural area, water features, outdoor fitness equipment, and courts would be associated with more steps and more energy expenditure for senior users. All design variables were measured based on surveys of parks in AutoCAD format provided by the Shanghai Greening Administration Bureau and local park administrators. The researchers visited all 15 parks, field-validated the survey drawings, corrected errors, identified activity zone types, and then calculated values for each park's design characteristic variables using AutoCAD (Figure 4).


Figure 3. Park scenes of the study parks.


Table 2. Seniors' physical activity variables and neighborhood park design variables.


Figure 4. Park activity zone type identification of Songhe Park (left) and Quyang Park (right).

Statistical Analyses

Statistical Analyses were conducted using IBM SPSS Statistics. Descriptive statistics were used to determine general characteristics of the collected sample data and park design characteristics. One-way ANOVA tests were then fitted to test whether seniors' physical activity, including total steps and energy expenditure, differed between parks with different design characteristics. In ANOVA analysis, park design characteristics were coded as categorical variables (Table 2). Park area was classified as smaller than 3 ha, 3–5 ha, and larger than 5 ha; trail length as <1 km, 1–2 km, and longer than 2 km; paved activity zone areas as <0.4 ha, 0.4–0.6 ha, and larger than 0.6 ha; and natural area as <2 ha, 2–4 ha, and larger than 4 ha.

We then used regression models to examine the relationships between park design characteristics and seniors' walking step and energy expenditure. In the analyses, variables of park area, total trail length, total paved activity zone area and total natural area were coded as continuous variables, other park design variables, including presence of water, presence of outdoor fitness equipment, and presence of court were coded as categorical variables. First, we examined whether our data demonstrated a multi-level structure (i.e., park participants nested within parks). If so, mixed models would be required for analysis. However, when we calculated the intra-class correlation coefficient, we found the between-cluster variance to be very small (ICC = 0.050 for total steps and ICC = 0.038 for energy expenditure); this ruled out any need for a mixed model. We fitted linear regression models to predict total steps and energy expenditure using park design characteristics and included seniors' demographic attributes as control variables. Total steps and energy expenditure were log-transformed, as they displayed right-skewed distributions. Since park design characteristic variables exhibited collinearity, stepwise models selection were applied for the both models.


Descriptive Statistics

Total of 257 senior park users participated in the study (Table 3). Those who returned with the pedometer turned off, or whose survey results were inconsistent with activity durations recorded on the pedometer, were excluded from the study. A total of 234 (91.05%) participants had valid pedometer data and demographic information and were included in the analysis. On average, each park had 16 valid senior participants (Min = 11, Max = 23, SD = 3.54). As indicated in Table 3, the average age of participants was around 70 years old (Min = 60, Max = 93, SD = 7.54) and the average BMI of participants was 23.45 (Min = 12.37, Max = 31.25, SD = 2.89). One hundred and thirty-two (56.4%) participants were male, 188 (80.3%) lived with their spouse, and 112 (47.9%) had a household monthly income between 5,000 and 10,000 CNY (749-1498 USD). Eighty-six (36.8%) seniors reported that their health was excellent or good, and 132 (56.4%) seniors felt their health was fair. One hundred and sixty-seven (71.4%) participants claimed that they came to the park for exercise, and 51 (21.8%) said they came with multiple purposes.


Table 3. Descriptive statistics for senior participants.

Out of all 234 participants with valid data, 191 recalled the types of physical activity they engaged in and the duration of each type of physical activity. On average, each participant walked 2,278 steps in the park (Min = 158, Max = 10,320, SD = 1,642.403). Of these 191 participants, one (0.52%) engaged in four types of physical activities; 11 (5.76%) engaged in three kinds of physical activities; 82 (42.93%) took parts in two kinds of physical activities; and 97 (50.79%) participated in only one type of physical activity. In total, participants reported 27 types of physical activities, the most frequently mentioned of which were walking (139 seniors, 72.77%), meeting and chatting with friends (29 seniors, 15.18%), and using outdoor fitness equipment (20 seniors, 10.47%). We calculated the energy expenditure of each participant for each activity by multiplying their weight (kg), the energy cost of a given physical activity (kcal·kg−1·h−1), and the duration of the physical activity (h−1). The total energy expenditure of a participant was then calculated as the sum of energy expenditures across all kinds of activities they performed. On average, each senior expended 148.27 kcal (Min = 14.50, Max = 1007.40, SD = 113.579) during their stay in the park.

Park Design Characteristics

Table 4 reports descriptive statistics for park design characteristics. On average, the 15 neighborhood parks had a surface area of 4.4 ha (Min = 1.61, Max = 8.92, SD = 2.219), a total trail length of 2.27 km (Min = 0.533, Max = 6.05, SD = 1.339), a total paved activity area of 0.49 ha (Min = 0.12, Max = 0.86, SD = 0.204), and a total natural area of 2.68 ha (Min = 0.96, Max = 5.00, SD = 1.218). Twelve parks (80%) had water features, six parks (40%) had outdoor fitness equipment, and four parks (26.7%) contained courts. Correlation analyses were used to detect associations between park design characteristics (Table 5). The results indicated that park area was positively associated with trail length, r (14) = 0.888, p < 0.001, total paved activity zone area, r (14) = 0.660, p < 0.005, and total natural area, r (14) = 0.962, p < 0.001. Parks with larger natural area also have longer trails r (14) = 0.858, p < 0.001, and larger total paved activity zone area, r (14) = 0.588, p < 0.005. Parks with courts also tend to have larger paved activity zone area, r (14) = 0.523, p < 0.005.


Table 4. Descriptive statistics for park design characteristics.


Table 5. Correlation matrix for park design characteristic variables.

Does Seniors' Total Step and Energy Expenditure Differ in Parks With Different Design Characteristics?

ANOVA analyses were performed to detect the differences in seniors' mean total step and mean energy expenditure in parks with different design characteristics. The results indicated that on average, seniors walk more steps in parks with larger surface area, F(2, 231) = 2.45, p = 0.089, longer trail, F(2, 231) = 2.85, p = 0.060, larger natural area, F(2, 231) = 6.27, p = 0.002, and outdoor fitness equipment, F(1, 231) = 4.00, p = 0.047 (Table 6, Figure 5). In particular, ANOVA post hoc (LSD) analyses indicated that senior participants in parks with <3 ha total area walked 507 fewer steps than those in parks with areas between 3 and 5 ha (p = 0.074), and 691 fewer steps compared to seniors in parks larger than 5 ha (p = 0.032) (Table 7). On average, seniors in parks with more than 2 km of trails walked 739 more steps (p = 0.021) than seniors in parks with <1 km of trails. Similarly, seniors in parks with <2 ha of natural area walked 724 fewer steps than those in parks with between 2 and 4 ha of natural area (p = 0.003), and 946 fewer steps (p = 0.002) than those in parks with more than 4 ha of natural area. Seniors expended more energy in parks without water, F(1, 189) = 5.608, p = 0.019, but no significant differences in seniors' average energy expenditure were detected between parks with different sizes, F(2, 188) =.725, p = 0.486, trail lengths, F(2, 188) = 1.101, p = 0.335, paved activity zone areas, F(2, 188) = 0.755, p = 0.472, natural areas, F(2, 188) = 0.188, p = 0.889, presence of outdoor fitness equipment, F(1, 189) = 1.081, p = 0.300, or presence of court, F(1, 189) = 0.014, p = 0.906.


Table 6. ANOVA analysis for seniors' total step, energy expenditure and park design characteristics.


Figure 5. Differences in seniors' total walking step and energy expenditure in parks with different design characteristics.


Table 7. AOVA post hoc (LSD) analysis for total step and neighborhood park design characteristics.

Do Relationships Between Seniors' Total Step and Energy Expenditure and Neighborhood Park Design Characteristics Still Hold When Controlling for Demographic Attributes?

The relationship of park design characteristics and seniors' total steps and energy expenditures were evaluated using multiple stepwise regression analyses (Table 8). We included age, gender, BMI, family income, health condition, and visit purpose as control variables. The multiple stepwise regression models indicated that seniors' walking step was negatively associated with senior age (β = −0.164, p = 0.011), but positively associated with natural area (β = 0.158, p = 0.015) and the presence of outdoor fitness equipment (β = 0.149, p = 0.021) in the park. These three factors explained 6.4% (p = 0.002) of the variance in step counts in the parks. Seniors' energy expenditure was positively related to BMI (β = 0.241, p = 0.001), household monthly income between 5,000 and 10,000 (β = 0.160, p = 0.024) and the presence of outdoor fitness equipment (β = 0.161, p = 0.024) in the park, these three factors explained 9.9% of the variance (p = 0.000) in senior energy expenditure.


Table 8. Total step, energy expenditure, and park design characteristics and senior demographic attributes (stepwise model).


This study examined the relationships between neighborhood park design characteristics and seniors' total steps and energy expenditure in the park, using both objective and self-reported measures. We sampled 15 different parks to enhance the generalizability of the results.

Seniors' Age, Household Monthly Income, and Physical Activity

The results indicated that younger seniors walked more in the park, and seniors with a household monthly income between 5,000 and 10,000 have larger energy expenditure than those with a monthly income <3,000 CNY. Existing research indicates that the young elderly tend to engage in more physical activity than the old elderly in daily life (53), and our findings suggest that this difference existed in park visits. Human skeletal muscle atrophies with age (54), and seniors in the 50–59 age have a better physical function than those in the 60–69 and 70–79 age groups (55). Therefore, young seniors are expected to walk more in the park. The needs of seniors in different decades and with different physical capabilities should be considered in urban park design and management. Seniors with higher incomes are more likely to participate in health promotion programs (56), report better health (57), have lower body mass index, and engage in more moderate and vigorous physical activity (58). That might explain our findings that compared to seniors with a household monthly income <3,000 CNY, seniors with a household monthly income between 5,000 and 10,000 CNY expend more energy in the park. On the other hand, urban park provides free settings for seniors with low income to engage in physical activity, efforts are needed to encourage those seniors to actively use urban parks.

Park Size, Natural Area, and Seniors' Walking

Our findings suggest that seniors in larger neighborhood parks walk more. However, existing research with adults indicates that park size is not associated with the chance whether a park is used for physical activity (17), and features rather than park size is more important for park-based physical activity (4). One possible explanation is that previous studies used binary measures of physical activity, while our study measured walking steps and energy expenditure using continuous variables, which allows for quantitative comparisons between parks. More time spent in a park has been shown to correlate with higher levels of physical activity (59). Larger parks provide more area to explore and may encourage seniors to stay and walk for longer periods. We also found that larger natural area was associated with more walking steps. The health benefits of walking in natural areas have long been recognized (60). Nature is important to seniors (61), and can help seniors release stress (62). Compared to other adults, seniors have a stronger motivation to walk in natural environment (8). Larger natural area may contribute to a better mood and attracted seniors to stay longer and walk more. The findings suggest that we can provide larger natural area to encourage seniors' walking in the park.

Trail Length and Seniors Walking

We found total trail length is related to seniors' total steps in the park. Existing research suggests that parks with tracks draw more seniors (4). A study in Missouri finds that users of a trail longer than 0.25 mile are more likely to report an increase in physical activity (63). Trail in the park is where seniors walking on, and longer trail can provide more opportunities for seniors to walk thus may facilitate seniors walking. In parks of limited area, designers can distribute longer trails to facilitate senior walking; further investigation is needed to explore how the characteristics of park trails may facilitate walking by seniors (64).

Outdoor Fitness Equipment and Seniors' Physical Activity

We found that the presence of outdoor fitness equipment was associated with total steps and energy expenditure of seniors. Fitness equipment can accommodate a variety of fitness goals, and their presence provides opportunities for physical activity beyond walking. Existing studies reported that outdoor fitness equipment in parks attracts senior users (49, 50), and seniors use this equipment with the primary motivation of exercising and improving health (7). Compared to other adults, seniors have less access to walking trails and indoor gyms (63). In contrast, outdoor fitness equipment can provide seniors with important exercise opportunities (50). Landscape architects can provide outdoor fitness equipment in urban parks to facilitate the physical activity of senior visitors, and how seniors use outdoor fitness equipment should be further explored.


The present study has some limitations that should be considered. The parks included in the study were neighborhood parks with areas of <10 ha, and thus the results may not be applicable to larger parks such as city parks, regional parks or natural reserves. Although we included 15 parks to ensure the representativeness of the sites, all are located in Shanghai, China. The patterns of park features and park use may differ in less-dense urban areas, in suburban and rural locations, and in other cultures. Additionally, we used a convenient sample of seniors visiting the parks who volunteered to participate in the study. It is uncertain whether this population group displayed characteristics that may influence the physical activity data systematically. Third, only step counts were measured, and only pedometers were used for measurement. Future studies should consider combining pedometers, accelerometers, heart-rate monitors, armbands, or multi-sensor devices for more accurate estimates of activity intensity, activity duration, and energy expenditure.


This study aimed to investigate the associations between neighborhood park design characteristics and seniors' walking and energy expenditure during park visits. The results indicated that park area, total trail length, and total natural area of the park were positive predictors of more walking. The presence of outdoor fitness equipment also contributed to more walking and energy expenditure. In addition, demographic and socioeconomic factors, as well as BMI are related to seniors' activities in parks. For example, senior's total step count was negatively associated with age; and their energy expenditure was positively related to BMI. More energy was also expended by seniors with a monthly household income between 5,000 and 10,000 CNY as compared to those with a monthly household income of <3,000 CNY. These findings can be used to guide park design and management to promote walking and active recreation in parks. For instance, planners and designers can include more natural areas and less impervious areas, create longer trails, and provide more outdoor fitness equipment in parks, especially in parks that are located in communities that demonstrate greater inactivity and obesity. Park use patterns and the needs of seniors with diverse demographic attributes should also be considered and addressed in future park design and management practice.

Data Availability Statement

The raw data can not be shared because sensitive location information is asked to be reserved by IRB.

Ethics Statement

Our study has been approved by the Institutional Review Board of Tongji University and we confirm that the patients/participants provided their written informed consent to participate in this study.

Author Contributions

All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.


This study was supported by National Science Foundation of China (No. 51508390) and the Fundamental Research Funds for the Central Universities of China (No. 22120180069).

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


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Keywords: neighborhood park, design characteristic, senior, walking, energy expenditure, pedometer

Citation: Zhai Y, Li D, Wang D and Shi C (2020) Seniors' Physical Activity in Neighborhood Parks and Park Design Characteristics. Front. Public Health 8:322. doi: 10.3389/fpubh.2020.00322

Received: 12 April 2020; Accepted: 12 June 2020;
Published: 29 July 2020.

Edited by:

Yi Lu, City University of Hong Kong, Hong Kong

Reviewed by:

Levent Dalar, Istanbul Bilim University, Turkey
Gulnihal Ozbay, Delaware State University, United States

Copyright © 2020 Zhai, Li, Wang and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Cheng Shi,