Frontiers in Aging Neuroscience

Original Research

Published on 21 Jul 2025

Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain

Gen Miura
Tomoyo Morita
Jihoon Park
Eiichi Naito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1501011

2,354 views

Review

Published on 18 Jul 2025

Motor symptoms of Parkinson’s disease: critical markers for early AI-assisted diagnosis

Ni Yang
Jing Liu
Dan Sun
Jiajun Ding
Lingzhi Sun
Xianghua Qi
Wei Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602426

5,631 views
1 citation

Original Research

Published on 17 Jul 2025

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

Mark H. Sundman
Yilin Liu
Nan-kuei Chen
Ying-hui Chou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597311

4,367 views
3 citations

Systematic Review

Published on 17 Jul 2025

Orthostatic hypotension in Parkinson’s disease: effects on clinical features and disease severity-a systematic review and meta-analysis

Hui Wang
Chi Zhang
Dongxun Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612960

2,287 views

Original Research

Published on 16 Jul 2025

Brain structural MRI marker for predicting conversion to Parkinson’s disease in individuals with prodromal symptoms

Chang-hyun Park
Uicheul Yoon
Phil Hyu Lee
Jinna Kim
Seung-Koo Lee
Na-Young Shin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579326

2,067 views

Original Research

Published on 16 Jul 2025

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study

Yushu Huang
Xifan Yang
Qi Wang
Adila Abula
Yue Dong
Wenyuan Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1532884

4,277 views
1 citation

Original Research

Published on 16 Jul 2025

Predictive value of pan-immune-inflammation value in the prognosis of adults with status epilepticus: a retrospective study

Jie Fu
Yifei Chu
Chenxin Zhao
Lilei Peng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1601816

1,256 views
1 citation

Original Research

Published on 16 Jul 2025

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly

Vivian Schultz
Benita Schmitz-Koep
Aurore Menegaux
Melissa Thalhammer
Severin Schramm
Su Hwan Kim
Claus Zimmer
Christian Sorg
Panteleimon Giannakopoulos
Marie-Louise Montandon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1542857

2,211 views

Review

Published on 16 Jul 2025

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

Yanrong Yang
Hua Chen
Qibing Liu
Yang Niu
Chunyang Mao
Rui Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1623050

4,129 views
4 citations

Original Research

Published on 16 Jul 2025

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer’s disease

Fenyang Chen
Tiantian Heng
Qi Feng
Rui Hua
Jiaojiao Wu
Feng Shi
Zhengluan Liao
Keyin Qiao
Zhiliang Zhang
Jianliang Miao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1621106

3,535 views
2 citations

Original Research

Published on 16 Jul 2025

Evaluation of non-motor symptoms in Parkinson’s disease using multiparametric MRI with the multiplex sequence

He Sui
Zhanhao Mo
Feng Shi
Qing Zhou
Dan Yu
Jiaqi Wang
Lin Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602245

2,059 views
1 citation

Review

Published on 15 Jul 2025

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

Amy F. T. Arnsten
Isabella Perone
Min Wang
Shengtao Yang
Stacy Uchendu
Dinara Bolat
Dibyadeep Datta

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610350

3,138 views
1 citation

Original Research

Published on 15 Jul 2025

Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey

Hui-Ying Fan
He-Li Sun
Yuan Feng
Qinge Zhang
Hua-Qing Xing
Qian-Hua Huang
Zhaohui Su
Teris Cheung
Chee H. Ng
Yu-Tao Xiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579560

3,165 views
1 citation

Systematic Review

Published on 11 Jul 2025

Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis

Han Han
Jinhao Zhang
Fan Zhang
Fanghui Li
Zhijian Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1510773

12,741 views
9 citations

Original Research

Published on 11 Jul 2025

Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism

Clémence Disdier
Clara Lhotellier
Stéphanie Wagner
Emile Andriambeloson
Frédéric Théodoro
Alain Pruvost
Thomas Joudinaud
Henri Bénech
Aloïse Mabondzo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597263

3,178 views
1 citation

Original Research

Published on 11 Jul 2025

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China

Jianping Lu
Guoen Cai
Naian Xiao
Kunmu Zheng
Qinyong Ye
Xiaochun Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566247

1,678 views
1 citation

Review

Published on 11 Jul 2025

Stem cell extracellular vesicles: a new dawn for anti-inflammatory treatment of neurodegenerative diseases

Miao Yu
Hongxia Ma
Xiaoyi Lai
Jiannan Wu
Mengmeng Shen
Junqiang Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592578

4,850 views
5 citations

Systematic Review

Published on 10 Jul 2025

Repetitive transcranial magnetic stimulation across neurodegenerative diseases: a systematic review and dose-response meta-analysis

Yu Zhang
Yulin Wang
Ke Xu
Chengguang Zhang
Peizhu Lv
Yan Bai
Shun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1615734

3,266 views

Original Research

Published on 09 Jul 2025

Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos

Ernesto G. Miranda-Morales
Daniel F. Ramos-Rosales
Alma C. Salas-Leal
Sergio M. Salas-Pacheco
Francisco X. Castellanos-Juárez
Edna M. Méndez-Hernández
Osmel La Llave-León
María S. Peñaherrera
Gerardo Quiñones-Canales
Oscar Arias-Carrión

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612544

1,768 views

Original Research

Published on 09 Jul 2025

Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury

Ryan P. McCann
Bethany Bowley
Monica Pessina
Qiong Yang
Hongqi Xin
Sarah A. DeVries
Mingjin Wang
Yi Zhang
Michael Chopp
Zhenggang Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1605144

3,113 views
2 citations

Original Research

Published on 09 Jul 2025

Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism

Wei Zhou
MengYue Tang
Bo Cheng
Ling Sun
HongYu Lin
Yang Fan
Nian Liu
Shushan Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566785

1,796 views

Mini Review

Published on 09 Jul 2025

Regulation of BBB function and pathological evolution of PD by microenvironment “spatiotemporal gradient”: unique advantages of microfluidic chips

Sixun Yu
Lingli Jiang
Min Song
Tao Yang
Ma Yuan
Xin Chen
Haifeng Shu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599509

3,224 views
2 citations

Systematic Review

Published on 08 Jul 2025

Sedentary behavior, cognition, and brain health in older adults: a systematic review

Marissa A. Gogniat
Junyeon Won
Carlos Cruz
Amaya Aranda
Aryan Verma
Swathi Gujral
Andrea M. Weinstein
Afsara B. Zaheed
Keith R. Cole
Kelsie M. Full

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1622049

3,988 views
4 citations

Original Research

Published on 08 Jul 2025

Altered automatic gaze processing in older adults

Roger Koenig-Robert
Boris Barrientos
Phoebe E. Bailey
Kiley Seymour

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592763

1,733 views

7,815 Publications

volumes

Volume 17 - 2025

Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain

Motor symptoms of Parkinson’s disease: critical markers for early AI-assisted diagnosis

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

Orthostatic hypotension in Parkinson’s disease: effects on clinical features and disease severity-a systematic review and meta-analysis

Brain structural MRI marker for predicting conversion to Parkinson’s disease in individuals with prodromal symptoms

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study

Predictive value of pan-immune-inflammation value in the prognosis of adults with status epilepticus: a retrospective study

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer’s disease

Evaluation of non-motor symptoms in Parkinson’s disease using multiparametric MRI with the multiplex sequence

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey

Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis

Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China

Stem cell extracellular vesicles: a new dawn for anti-inflammatory treatment of neurodegenerative diseases

Repetitive transcranial magnetic stimulation across neurodegenerative diseases: a systematic review and dose-response meta-analysis

Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos

Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury

Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism

Regulation of BBB function and pathological evolution of PD by microenvironment “spatiotemporal gradient”: unique advantages of microfluidic chips

Sedentary behavior, cognition, and brain health in older adults: a systematic review

Altered automatic gaze processing in older adults