Frontiers in Endocrinology | Diabetes: Molecular Mechanisms

Original Research

Published on 06 Mar 2026

Age- and diet-dependent progression of retinal microvascular injury in GCK-MODY under metabolic stress

in Diabetes: Molecular Mechanisms

Yadi Huang
Yang Liu
Yiqing Wang
Xuan Liu
Shuhui Ji
Shanshan Chen
Hua Shu
Yu Fan
Ming Liu
Xin Li

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1744691

Original Research

Published on 06 Mar 2026

Ultrasound combined with microbubbles promotes diabetic wound healing by regulating macrophage polarization

in Diabetes: Molecular Mechanisms

Huabin Yang
Qian Feng
Nan Huang
Wen Zhang
Tao Jiang
Rui Wang
Linling Li
Jie Tao
Juan Tang
Zhong Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1781906

Review

Published on 06 Mar 2026

Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy

in Diabetes: Molecular Mechanisms

Casandra Carrillo
Teri L. Belecky-Adams
Nader Sheibani

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1771836

Original Research

Accepted on 05 Mar 2026

Mechanistic insights of hypoglycemic components from Polygonatum Polysaccharide

in Diabetes: Molecular Mechanisms

Guanhai Dai
Zeming Ren
Sisi Chen
Zhongxiu Guo
Xiyu Mei
Yeling Tong
Yane Liu
Ziyun Gao
Xuan Chen

Frontiers in Endocrinology

Review

Published on 27 Feb 2026

HMGB1: a key molecule linking chronic inflammation to complications in type 2 diabetes mellitus and a target for exercise intervention

in Diabetes: Molecular Mechanisms

Fu Pengyu
Xu Huiyun
Gong Lijing

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1769497

138 views

Original Research

Accepted on 26 Feb 2026

Unveiling the TrkA-p35/CDK5 Axis: A Novel Therapeutic Target in Diabetic Kidney Disease

in Diabetes: Molecular Mechanisms

Xia Wenbo
MEI WANG
Yongcai Gao
Yonghua Liu
Jing Li
Hongliang Zhang
Hongyan Luo
Dongyang Shen
Jing E
Bo Li

Frontiers in Endocrinology

Original Research

Published on 26 Feb 2026

Inflammatory markers associated with albuminuria and early atherosclerosis in type 2 diabetic kidney disease: a cross-sectional study

in Diabetes: Molecular Mechanisms

Ainhoa González-Luis
Orlando Siverio-Morales
Carolina Hernández-Carballo
Carmen Mora-Fernández
Ernesto Martín-Núñez
Andrea Reyes-Carrión
J. Diego Carlos-Monzón
Juan F. Navarro-González
Javier Donate-Correa

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1732900

344 views

Original Research

Accepted on 23 Feb 2026

Integrating Machine Learning and Immune Infiltration Analysis to Identify Core Genes and Construct a Diagnostic Model for Type 2 Diabetes Mellitus

in Diabetes: Molecular Mechanisms

Xiaonan Zhang
Li Li
Fangqin Cui
Mingji Hu
Bao Li
Bang Du
Qingqing Fang
Dake Huang

Frontiers in Endocrinology

Original Research

Accepted on 23 Feb 2026

Epigenetic Inhibition of Class I Histone Deacetylases by MS-275 Attenuates Diabetic Skeletal Muscle Atrophy via Akt/ARK5–FoxO and Myostatin–Smad Signaling

in Diabetes: Molecular Mechanisms

Youngho Son
Hye-Eun Byeon
Sung-E Choi
Youngha Kim
Yu Jung Heo
Soon Beom Kwon
Jaemyung Choi
Seung Jin Han
Jayoung Jeon
Hae Jin Kim

Frontiers in Endocrinology

Systematic Review

Published on 23 Feb 2026

Type 2 diabetes mellitus associated microRNAs in tuberculosis susceptibility: a systematic review and bioinformatic analysis

in Diabetes: Molecular Mechanisms

Rodolfo L. Chávez-Domínguez
Mercedes Viettri
Martha Torres
Itzel A. Corona-Galvan
Emilio Hernández-Diego
Mauricio Castañón-Arreola
Claudia Carranza

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1760933

523 views

Review

Accepted on 19 Feb 2026

Exerkines in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects

in Diabetes: Molecular Mechanisms

Juming Zhu

Frontiers in Endocrinology

Original Research

Accepted on 19 Feb 2026

Syntaxin 4 (STX4) protects islet b-cells from cytokine-induced senescence

in Diabetes: Molecular Mechanisms

Miwon Ahn
Sneha Susan Varghese
Erika McCown
Supriyo Bhattacharya
Katarzyna Dabrowska
Nathaniel Hansen
Patrick Pirrotte
Debbie C Thurmond
Sangeeta Dhawan

Frontiers in Endocrinology

Review

Published on 18 Feb 2026

The role of PYY in improving insulin resistance

in Diabetes: Molecular Mechanisms

Chunyan Liu
Na Ren
Haixin Zhang
Jian Ma

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1784709

621 views

Original Research

Published on 13 Feb 2026

Metabolomics identifies chenodeoxycholic acid as a protective factor in diabetic foot ulcers

in Diabetes: Molecular Mechanisms

Ying Li
Ran Guo
Lu Lv
Tao Jiang
Chenning Zhang
Jiangying Chang
KeYan Hu
Huifang Peng
Lulu Chen
Ran Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1754743

363 views

Review

Published on 13 Feb 2026

Endoplasmic reticulum stress in skeletal muscle dysfunction of type 2 diabetes: mechanisms and therapeutic implications

in Diabetes: Molecular Mechanisms

Xin Wang
Mingdi Li
Zengpeng Chi
Mingshan Wang
Jiayi Liu
Ailin Li
Bailin Song
Le Tong

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1769545

445 views

Review

Published on 13 Feb 2026

Role of metabolic reprogramming and lactylation in diabetic nephropathy: molecular mechanisms and therapeutic prospects – a narrative review

in Diabetes: Molecular Mechanisms

Zongtao Li
Yashi Wang
Die Fang
Wenfeng Ye
Xueqin Zhang
Zhiqiang Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1770531

454 views

Original Research

Published on 12 Feb 2026

Effects and interactive effects of high-altitude environment on metabolism in normal and diabetic populations: a comparative metabolomics study

in Diabetes: Molecular Mechanisms

Jing Shi
Jinli Meng
Chenghui Zhang
Li Feng
Suyuan Wang
Hengyan Li
Yongyue Guo
Xin Hu
Xiaomei Li
Wanlin He

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1736270

419 views

Systematic Review

Published on 12 Feb 2026

Lipoprotein-associated phospholipase A2 and complications of diabetes mellitus: a systematic review and meta-analysis

in Diabetes: Molecular Mechanisms

Sujuan Guo
Xiaojuan Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1765261

404 views

Original Research

Published on 12 Feb 2026

TangShenWeiNing formula alleviates diabetic kidney disease by inhibiting ferroptosis via AMPK pathway in renal tubular epithelial cells

in Diabetes: Molecular Mechanisms

Ye Jiang
Jing Chang
You Guo
Zhe Liu
Xiaomeng Feng

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1749994

325 views

Review

Published on 12 Feb 2026

Mechanisms and applications of natural plant ingredients in modulating amino acid metabolism for the improvement of diabetic retinopathy: a review

in Diabetes: Molecular Mechanisms

Le-yi Zhang
Tian-yi Zhang
Ya-juan Zheng
Jia-xin Li
Hu-rong Chen
Jing Cao
Teng Dan

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1745507

435 views

Review

Published on 11 Feb 2026

The SGLT2 inhibitor checklist: a comprehensive review of perioperative and acute phase safety management

in Diabetes: Molecular Mechanisms

Bin Deng
Wenhua Liu
Qingmin Chu

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1777334

740 views

Systematic Review

Published on 09 Feb 2026

Clinical parameters and emerging biomarkers of partial remission in pediatric type 1 diabetes: a systematic review

in Diabetes: Molecular Mechanisms

Camille Dikranian
Oumayma Hadara
Philippe A. Lysy

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1758848

1,028 views

Original Research

Published on 03 Feb 2026

Aerobic exercise and MOTS-c attenuate diabetic myocardial fibrosis via inhibition of the THBS1/TGF-β signaling pathway

in Diabetes: Molecular Mechanisms

Zhiyu Li
Tutu Wang
Yu Fu
Feilong Chen
Shunchang Li

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1732329

490 views

Review

Published on 03 Feb 2026

Ferroptosis in diabetic retinopathy: from pathogenic mechanisms to translational prospects

in Diabetes: Molecular Mechanisms

Jieyu Jiang
Zhimin Liu
Xiangdong Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1765089

1,002 views

860 articles

articles

Age- and diet-dependent progression of retinal microvascular injury in GCK-MODY under metabolic stress

Ultrasound combined with microbubbles promotes diabetic wound healing by regulating macrophage polarization

Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy

Mechanistic insights of hypoglycemic components from Polygonatum Polysaccharide

HMGB1: a key molecule linking chronic inflammation to complications in type 2 diabetes mellitus and a target for exercise intervention

Unveiling the TrkA-p35/CDK5 Axis: A Novel Therapeutic Target in Diabetic Kidney Disease

Inflammatory markers associated with albuminuria and early atherosclerosis in type 2 diabetic kidney disease: a cross-sectional study

Integrating Machine Learning and Immune Infiltration Analysis to Identify Core Genes and Construct a Diagnostic Model for Type 2 Diabetes Mellitus

Epigenetic Inhibition of Class I Histone Deacetylases by MS-275 Attenuates Diabetic Skeletal Muscle Atrophy via Akt/ARK5–FoxO and Myostatin–Smad Signaling

Type 2 diabetes mellitus associated microRNAs in tuberculosis susceptibility: a systematic review and bioinformatic analysis

Exerkines in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects

Syntaxin 4 (STX4) protects islet b-cells from cytokine-induced senescence

The role of PYY in improving insulin resistance

Metabolomics identifies chenodeoxycholic acid as a protective factor in diabetic foot ulcers

Endoplasmic reticulum stress in skeletal muscle dysfunction of type 2 diabetes: mechanisms and therapeutic implications

Role of metabolic reprogramming and lactylation in diabetic nephropathy: molecular mechanisms and therapeutic prospects – a narrative review

Effects and interactive effects of high-altitude environment on metabolism in normal and diabetic populations: a comparative metabolomics study

Lipoprotein-associated phospholipase A2 and complications of diabetes mellitus: a systematic review and meta-analysis

TangShenWeiNing formula alleviates diabetic kidney disease by inhibiting ferroptosis via AMPK pathway in renal tubular epithelial cells

Mechanisms and applications of natural plant ingredients in modulating amino acid metabolism for the improvement of diabetic retinopathy: a review

The SGLT2 inhibitor checklist: a comprehensive review of perioperative and acute phase safety management

Clinical parameters and emerging biomarkers of partial remission in pediatric type 1 diabetes: a systematic review

Aerobic exercise and MOTS-c attenuate diabetic myocardial fibrosis via inhibition of the THBS1/TGF-β signaling pathway

Ferroptosis in diabetic retinopathy: from pathogenic mechanisms to translational prospects