Frontiers in Endocrinology | Diabetes: Molecular Mechanisms

Original Research

Published on 03 Nov 2025

Comprehensive transcriptomic profiling reveals tissue-specific molecular signatures and dysregulated pathways in human diabetic foot ulcers

in Diabetes: Molecular Mechanisms

Guangrong Hu
Ayesha Nisar
Sawar Khan
Wen Li
Enfang Zhu
Haoling Cui
Guiqin Zhang
Yonghan He
Hui Sun

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1669205

242 views

Original Research

Published on 03 Nov 2025

U-TXM: a novel biomarker for early detection of diabetic kidney disease

in Diabetes: Molecular Mechanisms

Yujie Jin
Jiahao Xu
Yan Ma
Chunchen Ni
Yan Yao
Shujuan Shang
Mengru Wang
Chunyan Xing
Song Dong
Chaoqun Xiong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1682136

256 views

Original Research

Accepted on 31 Oct 2025

Comparison of the predictive value of different non-insulin-based insulin resistance indices for acute kidney injury in patients with sepsis: a retrospective study

in Diabetes: Molecular Mechanisms

Shijie Wang
Ruowen Li
Li Zhang
Jiaqi Wang
Tingbin Xie
Xinying Wang

Frontiers in Endocrinology

Original Research

Published on 31 Oct 2025

Deciphering the epigenetic role of KDM4A in pancreatic β-like cell differentiation from iPSCs

in Diabetes: Molecular Mechanisms

Felipe Arroyave
Lina Méndez-Castillo
Fernando Lizcano

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1697097

234 views

Original Research

Published on 31 Oct 2025

Genetic/epigenetic RNA dysregulation in type 2 diabetes mellitus complicated with ischemic heart disease

in Diabetes: Molecular Mechanisms

Eslam S. Sedkey
Marwa Matboli
Mohamed G. Seadawy
Marwa G.A. Hegazy

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1687145

403 views

Systematic Review

Published on 30 Oct 2025

Yerba Maté and its impact on glycemic control and metabolic health: a systematic review and meta-analysis

in Diabetes: Molecular Mechanisms

Daiping Li
Liantian Yue
Xuchao Peng
Ling Chen
Taiping Lin
Li Huang
Yadong Liu
Jirong Yue
Xiaoli Huang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1641592

720 views

Original Research

Published on 29 Oct 2025

Identification and validation of key mitophagy-related biomarkers in the pathogenesis of proliferative diabetic retinopathy

in Diabetes: Molecular Mechanisms

Yifan Liu
Ye Zhou
Jie Chen
Jiahui Jin
Xueying Wang
Xi Wang
Jieping Zhang
Jiao Li
Junfang Zhang
Ling Zhu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1652898

284 views

Original Research

Published on 28 Oct 2025

Allyl nonanoate as a novel bile-derived biomarker in metabolic dysfunction-associated steatotic liver disease

in Diabetes: Molecular Mechanisms

Soo Hyeon Lee
Jonghwan Kim
Sung Ryol Lee
Bum Soo Lee
Ki Hyun Kim
Dae Won Jun
Chung Sub Kim
Kyung A Kang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1707492

421 views

Review

Accepted on 24 Oct 2025

Diabetic kidney disease macrophage cholesterol efflux: a revolution from metabolism to immune

in Diabetes: Molecular Mechanisms

JinJin Wang
Qin Zhu
Yi Cai
Yuxi Feng

Frontiers in Endocrinology

404 views

Original Research

Accepted on 23 Oct 2025

PSCP, a Novel Reactive Sulfur Donor, Activates Keap1-Nrf2 Signaling and Attenuates Mitochondrial Dysfunction in Diabetic Retinopathy

in Diabetes: Molecular Mechanisms

Kexin Li
Ruiying Ji
Youbang Chen
Yiwen Wang
Yiyan Guo
Xiang Li
Hui Zhang
Zaopeng He
Liang Guo
Chuntao Yang

Frontiers in Endocrinology

385 views

Original Research

Accepted on 23 Oct 2025

Association of TNF-α Polymorphisms rs1800629 (−308G>A) and rs361525 (−238G>A) with Type 2 Diabetes Mellitus in the Punjabi Population of Pakistan

in Diabetes: Molecular Mechanisms

Muhammad Waqar
Tsai-Sung Tai
Abdul Qadeer
Umar Aziz
Mohammad Abohassan
Chien-Chin Chen
Sawar Khan

Frontiers in Endocrinology

345 views

Original Research

Accepted on 22 Oct 2025

Multi level effects of Sanghuang Tongxie Formula on type 2 diabetes rats: a comprehensive analysis from intestinal bacteria to metabolome and transcriptome

in Diabetes: Molecular Mechanisms

Jiaxuan Liu
Sufen Bai
Chenxi Wu
Chunyu Tia
Qianru Fu
Xiujuan Gao
Biwei Zhang
Ji ' An Li
La Xiaojin

Frontiers in Endocrinology

360 views

Original Research

Published on 22 Oct 2025

MODY PDX1P33T: a mouse model reveals phenotypic divergence from human disease

in Diabetes: Molecular Mechanisms

Aliona Harten
Maximilian R. Schmidtke
Florian Giesert
David A. Skerrett-Byrne
Raffaele Teperino
Gerhard K. H. Przemeck
Martin Hrabě de Angelis

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1680893

659 views

Review

Accepted on 21 Oct 2025

Impact of structure and formulation changes on the function of insulin products

in Diabetes: Molecular Mechanisms

Yeonjin Yang
Md Shahinozzaman
Hyunsu Shin
Sujata Bupp
Carole Sourbier

Frontiers in Endocrinology

394 views

Review

Accepted on 21 Oct 2025

The role of dysregulated copper metabolism in diabetes and its complications: A review

in Diabetes: Molecular Mechanisms

Chen Wang
Junhong Wu
Yan Wang
Chengcheng Huang
Mengjuan Wei
Yufei Zhang
Renchu Shen
JingWu Wang

Frontiers in Endocrinology

361 views

Original Research

Accepted on 20 Oct 2025

Sodium-glucose cotransporter 2 inhibitors—but not insulin— enhance renal branched-chain amino acid catabolism

in Diabetes: Molecular Mechanisms

Moeko Sakamoto
Nao Hasuzawa
Lixiang Wang
Kyoko Tashiro
Miyuki Kitamura
Shimpei Iwata
Nobuhiko Wada
Seiji Nomura
Sawako Moriyama
Mizuki Gobaru

Frontiers in Endocrinology