Frontiers in Endocrinology | Diabetes: Molecular Mechanisms

Original Research

Published on 10 Oct 2025

Mechanistic insights into modified Danggui Buxue Decoction for diabetic retinopathy via integrative analysis

in Diabetes: Molecular Mechanisms

Lee Yam Poon
Li Mei Hsu
Lai Kwan Lam
Xiaoqing Huang
Pengli Xu
Qiuer Liang
Pengcheng Xie
Shuyu Yang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1648831

666 views

Original Research

Published on 10 Oct 2025

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes

in Diabetes: Molecular Mechanisms

Chelsea G. Johansen
Kenedee Lam
Nikki L. Farnsworth

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1675043

335 views

Original Research

Published on 09 Oct 2025

Development of targeted drugs for diabetic retinopathy using Mendelian randomized pharmacogenomics

in Diabetes: Molecular Mechanisms

Guodan Liu
Miao Tian
Xinge Li
Xichen Wang
Songhao Zhang
Gali Bai
Xuyang Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1632691

629 views

Original Research

Published on 09 Oct 2025

Metabolomics integrated with network pharmacology and serum-urine pharmacochemistry unveils the antidiabetic mechanism of Anemarrhenae Rhizoma

in Diabetes: Molecular Mechanisms

Xunlong Zhong
Huaidong Peng
Chang Xiao
Chunhua Xiao
Xinyu Zhu
Haixuan Liang
Ruolun Wang
Yanmei Zhong
Jingwen Feng

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1618584

539 views

Original Research

Published on 09 Oct 2025

Association of systemic immune-inflammation index with type 2 diabetes mellitus and its prognostic significance: a systematic review and meta-analysis

in Diabetes: Molecular Mechanisms

Ru Xu
Lele Jiang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1572089

430 views

Original Research

Accepted on 07 Oct 2025

MODY PDX1P33T: A Mouse Model Reveals Phenotypic Divergence from Human Disease

in Diabetes: Molecular Mechanisms

Aliona Harten
Maximilian R Schmidtke
Florian Giesert
David Skerrett-Byrne
Raffaele Teperino
Gerhard Przemeck
Martin Hrabě de Angelis

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1680893

153 views

Review

Published on 07 Oct 2025

The emerging role of extracellular vesicles in diabetes and complications: mechanistic insights and translational prospects

in Diabetes: Molecular Mechanisms

Siyuan Liu
Zhicheng Pan
Xuzhuo Chen
Zhenlin Wang
Wei Zhong
Jitao Ling
Yixuan Chen
Panpan Xia
Deju Zhang
Xiao Liu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1674028

517 views

Review

Published on 07 Oct 2025

Inflammation, diabetic foot and related treatments

in Diabetes: Molecular Mechanisms

Yuqi Qin
Shan Deng

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1676621

461 views

Original Research

Published on 07 Oct 2025

HOMA-AD, inflammation, and adipose tissue dysfunction as key drivers of immunometabolic risk in people living with HIV and type 2 diabetes

in Diabetes: Molecular Mechanisms

Elsa J. Anaya-Ambriz
Tania E. Holguín-Aguirre
Paula Catalina Méndez-Ríos
Monserrat Alvarez-Zavala
Luz A. González-Hernández
Jaime F. Andrade-Villanueva
Pedro Martínez Ayala
Rodolfo I. Cabrera-Silva
Karina Sánchez-Reyes

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1669148

538 views

Editorial

Accepted on 02 Oct 2025

Exploring the expanding therapeutic value of glucose-dependent insulinotropic polypeptide receptor signaling. An editorial for "The Impact of GIP/GIPR on Metabolic Diseases: How the Field Is Evolving"

in Diabetes: Molecular Mechanisms

Kirk M. Habegger
Alejandra Tomas
Roger Chen
Charles Harris
William C Roell
Tamer Coskun

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1710843

404 views

Original Research

Published on 02 Oct 2025

Early pathological changes in the liver and kidney of non-obese diabetic (NOD) mice: involvement of iron accumulation and ferroptosis

in Diabetes: Molecular Mechanisms

Ana Stancic
Milica Markelic
Nevena Savic
Ksenija Velickovic
Vesna Martinovic
Andjelija Gudelj
Danica Velickovic
Ilijana Grigorov
Vesna Otasevic

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1673012

783 views

Original Research

Published on 01 Oct 2025

Multi-omics analysis of hepatic outcomes in T2DM-MAFLD patients treated with semaglutide: a single-centre, longitudinal, data-driven study

in Diabetes: Molecular Mechanisms

Shu Niu
Shuchun Chen
Di Wu
Chenxi Wang
Jianchao Xu
Jiantong Yin
Yubin Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1650729

849 views

Original Research

Published on 01 Oct 2025

Alterations of oral microbiota and cytokines profile in children and young adults with type 1 diabetes

in Diabetes: Molecular Mechanisms

Luana Aldegheri
Eulalia Catamo
Nunzia Zanotta
Giuseppina Campisciano
Carolina Cason
Andrea Conti
Chiara Cipullo
Milena Cadenaro
Gianluca Tornese
Chiara Navarra

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1629185

552 views

Original Research

Published on 30 Sep 2025

A systematic analysis of the global disease burden of type 2 diabetes mellitus attributable to high intake of processed meat in 204 countries (1990-2021)

in Diabetes: Molecular Mechanisms

Wangchu Ze
Rui Su
Ruiyu Huang
Yanxia Guo
Xiaofang Yang
Baolu Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1635831

1,037 views

Original Research

Accepted on 29 Sep 2025

GROWTH FACTOR AND HYPOXIA-INDUCIBLE FACTOR ALPHA CONTENT IN THE RETINA OF MALE WISTAR RATS IN EXPERIMENTAL DIABETIC RETINOPATHY AND THE EFFECT OF CELLULAR PROTEIN KINASE BLOCKADE

in Diabetes: Molecular Mechanisms

K.O. Usenko
Olena Strubchevska
S.O. Rykov
M.S. Babenko
Kateryna Strubchevska
Oleksandra Kozyk
S.V. Ziablitsev
Marko Kozyk

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1643445

244 views

Review

Published on 29 Sep 2025

Multi-dimensional roles of sodium-glucose cotransporter 2 inhibitors: beyond hypoglycemic and cardiorenal protection

in Diabetes: Molecular Mechanisms

Siyu Li
Yaqi Wang
Quan Gong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1641699

574 views