Frontiers in Endocrinology | Diabetes: Molecular Mechanisms

Original Research

Published on 04 Dec 2025

Multi-fluid, multi-omics signatures of insulin resistance and incident type 2 diabetes among Puerto Rican adults

in Diabetes: Molecular Mechanisms

Tong Xia
Zicheng Wang
Teja Lakamraju
Danielle E. Haslam
Saravanan Thangarajan
David T. W. Wong
Liming Liang
Kaumudi Joshipura
Meir J. Stampfer
Frank B. Hu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1699656

Review

Published on 04 Dec 2025

Metabolic-stress-induced mitochondrial calcium dysregulation: a central hub in diabetic cardiomyopathy pathogenesis and treatment

in Diabetes: Molecular Mechanisms

Siqi Deng
Fatemeh Tayefi
Yunpeng Jin

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1696344

177 views

Original Research

Published on 03 Dec 2025

Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations

in Diabetes: Molecular Mechanisms

Maria Barranco-Altirriba
Minerva Granado-Casas
Oscar Yanes
Jordi Capellades
Alexandra Junza
Josep Franch-Nadal
Joan Vendrell
Gemma Llauradó
Sergio Valdés
Eva García-Escobar

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1706886

270 views

Original Research

Published on 03 Dec 2025

Association of serum miR-99a level and metabolic dysfunction-associated steatotic liver disease, serum mTOR levels in patients with type 2 diabetes mellitus

in Diabetes: Molecular Mechanisms

Yangyang Zhang
Yuqiong Zuo
Qian Chen
Yaqiang Cui
Yanxia Bao
Panpan Jiang
Jing Liu
Jinxing Quan
Juxiang Liu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1724108

216 views

Review

Published on 01 Dec 2025

Immunometabolic crossroads: infections as bidirectional modulators in diabetes and metabolic syndromes

in Diabetes: Molecular Mechanisms

Md. Sharifull Islam
Sawda Binte Monir
Nabila Haque
Marshia Ahmed Vabna
Jie Fan
Yikui Li
Ishatur Nime
Farahnaaz Feroz
Mrityunjoy Acharjee
Fan Pan

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1710157

446 views

Original Research

Accepted on 28 Nov 2025

Apolipoprotein E genotypes are associated with diabetic peripheral neuropathy in Lebanese adults with type 2 diabetes: a case-control study

in Diabetes: Molecular Mechanisms

Rita Nemr
SABRINA ZIDI
Akram Echtay
Eddie Racoubian
Nisrine Beydoun
Wassim Almawi

Frontiers in Endocrinology

215 views

Original Research

Accepted on 28 Nov 2025

Inulin and Lycium barbarum polysaccharides mitigate the diabetic inflammatory response by modulating bile acid metabolism to enhance regulatory T cell (Treg) activation in a rat model of diabetes

in Diabetes: Molecular Mechanisms

Hai Xia Lu
Hongyan Luo
Peiling Li
Yan Yang
Shilu Cao
Zhang Yanfang
Hongxia Ma
Qian Zhao
Yali Zheng
Hao Wang

Frontiers in Endocrinology

Review

Published on 28 Nov 2025

Lactylation in diabetes mellitus and its complications: mechanisms of action and therapeutic potential - recent advances

in Diabetes: Molecular Mechanisms

Min Zhou
Lan Liu
Yihong Sun
Xiaoshu Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1710645

265 views

Review

Accepted on 27 Nov 2025

Mitochondrial Bioenergetics Dysfunction in T2DM: Linking Oxidative Stress to Insulin Resistance

in Diabetes: Molecular Mechanisms

Zheng Feng
Zhenlin Tan
Donghui Lu

Frontiers in Endocrinology

Original Research

Published on 27 Nov 2025

Parent-of-origin effects of phosphatidyl inositol-bisphosphate hydrolysis pathway genes on type 2 diabetes and the modification effect by obesity

in Diabetes: Molecular Mechanisms

Yinxi Tan
Hexiang Peng
Siyue Wang
Poning Hu
Yi Zheng
Haodong Zhang
Huangda Guo
Yixin Li
Hanyu Zhang
Yiqun Wu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1705584

306 views

Original Research

Published on 27 Nov 2025

Antibiotic-induced gut microbiota depletion enhances glucose tolerance linked to GLP-1 signaling

in Diabetes: Molecular Mechanisms

Alexandra Kellenberger
Revati Sumukh Dewal
Alice de Wouters d’Oplinter
Andreas Sichert
Markus Heine
Marceline M. Fuh
Emma Slack
Tenagne Delessa Challa
Christian Wolfrum

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1684155

542 views

Original Research

Published on 26 Nov 2025

Transcriptomic profiling of diabetic retinopathy: insights into RPL11 and bisphenol A

in Diabetes: Molecular Mechanisms

Jian Zhang
Xin Yang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1705233

401 views

Mini Review

Published on 26 Nov 2025

Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes

in Diabetes: Molecular Mechanisms

Ashley Ling
Katherine R. Schultz
Jefferson D. Knight
Colin T. Shearn
Sharon Baumel-Alterzon

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1722623

361 views

Review

Accepted on 24 Nov 2025

Molecular Analysis of Long COVID and New-onset Diabetes Mellitus: Pathobiological Relationships and Current Mechanistic Views

in Diabetes: Molecular Mechanisms

Getasew Shitaye
Muluabay Getie
Zewdie Mekonnen
Gianluca D'Abrosca
Roberto Fattorusso
Carla Isernia
Asmare Amuamuta
Gaetano Malgieri

Frontiers in Endocrinology

Original Research

Published on 24 Nov 2025

The regulatory effects of realgar and cinnabar on glucose metabolism in mice

in Diabetes: Molecular Mechanisms

Yifan Zhang
Qingsong Qu
Ertong Dai
Ruiyan Liu
Bilin Jin
Zixuan Lu
Hui Kong
Yue Zhang
Huihua Qu
Yan Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1658148

275 views

Review

Accepted on 21 Nov 2025

Klotho in Diabetes Mellitus: Research Progress and Clinical Implications

in Diabetes: Molecular Mechanisms

Tingyuan Zhu
Songfeng Zhao
Ning Lu

Frontiers in Endocrinology

309 views