Frontiers in Endocrinology | Diabetes: Molecular Mechanisms

Original Research

Published on 22 Sep 2025

Ischemic postconditioning ameliorates diabetic cerebral ischemia via activating the brain-derived neurotrophic factor–tropomyosin receptor kinase B–hypoxia-inducible factor 1α–Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 pathway to induce microglial mitophagy and suppress A1 astrocyte-mediated neuroinflammation

in Diabetes: Molecular Mechanisms

Ling Zhao
Yuanyuan Han
Ying Wang
Tingyu Ke
Shiying Huang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1620004

215 views

Systematic Review

Accepted on 19 Sep 2025

The rs7799039 Variant in the Leptin Gene Promoter Drives Insulin Resistance Through Reduced Serum Leptin Levels

in Diabetes: Molecular Mechanisms

Yongyan Song
Youjin Zhang
Xinyu Liu
Wang Gong
Yinquan Ai
Binger Shen
Jing Li
Ya Liu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1589575

297 views

Review

Published on 19 Sep 2025

Gut microbiota-derived short-chain fatty acids mediate the antifibrotic effects of traditional Chinese medicine in diabetic nephropathy

in Diabetes: Molecular Mechanisms

Haiyan Jiang
Xiaoran Wang
Wei Zhou
Zhili Huang
Wen Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1643515

460 views

Original Research

Accepted on 18 Sep 2025

Multi-omics analysis of hepatic outcomes in T2DM-MAFLD patients treated with semaglutide: A single-centre, longitudinal, data-driven study

in Diabetes: Molecular Mechanisms

Shu Niu
Shuchun Chen
Di Wu
Chenxi Wang
Jianchao Xu
Jiantong Yin
Yubin Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1650729

376 views

Original Research

Published on 18 Sep 2025

Future horizons in diabetes treatment: hypoglycemic activity of [1,2,4]triazino[2,3-c]quinazoline derivatives

in Diabetes: Molecular Mechanisms

Serhii Trzhetsynskyi
Inna Nosulenko
Anna Kinichenko
Dmytro Skoryna
Halyna Berest
Volodymyr Shvets
Oleksii Voskoboinik
Serhii Kovalenko
Pavlo Petakh
Oleksandr Kamyshnyi

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1638013

886 views

Review

Published on 18 Sep 2025

Gut microbiota dysbiosis in diabetic nephropathy: mechanisms and therapeutic targeting via the gut-kidney axis

in Diabetes: Molecular Mechanisms

Haiyan Jiang
Xiaoran Wang
Wei Zhou
Zhili Huang
Wen Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1661037

498 views

Review

Accepted on 17 Sep 2025

Exploring Type 2 Diabetes Mellitus: A Comprehensive Review of the Pathophysiology, Management and Prevention, Current Insights and Future Perspectives

in Diabetes: Molecular Mechanisms

Himanshu .
Suryakant Verma
Usha Singh
Ashu Rathi
Kshitiz Sahu
Aishvi Gupta

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1674756

253 views

Review

Accepted on 16 Sep 2025

The Emerging Role of Extracellular Vesicles in Diabetes and Complications: Mechanistic Insights and Translational Prospects

in Diabetes: Molecular Mechanisms

Siyuan Liu
Zhicheng Pan
Xuzhuo Chen
Zhenlin Wang
Wei Zhong
Jitao Ling
Yixuan Chen
Panpan Xia
Deju Zhang
Xiao Liu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1674028

220 views

Original Research

Published on 16 Sep 2025

Association of MIF rs1007888 and ARAP1 rs1552224 genetic variants with the risk of gestational diabetes mellitus in a chinese population; case study and meta-analysis

in Diabetes: Molecular Mechanisms

Yuxuan Zhang
Yanying Wu
Qiaoli Zeng
Watson Ray Gyan
Sining Huang
Xiner Dai
Jia Liu
Xin Liu
Yue Wei
Runmin Guo

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1650782

711 views

Hypothesis and Theory

Published on 16 Sep 2025

A mathematical model of insulin action on acinar tissue linking histology and radiological imaging of the pancreas

in Diabetes: Molecular Mechanisms

John Virostko

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1676627

514 views

Original Research

Accepted on 15 Sep 2025

HOMA-AD, Inflammation, and Adipose Tissue Dysfunction as Key Drivers of Immunometabolic Risk in People Living with HIV and Type 2 Diabetes

in Diabetes: Molecular Mechanisms

Elsa Janneth Anaya Ambriz
Tania Elisa Holguin Aguirre
Paula Catalina Méndez Ríos
Monserrat Alvarez Zavala
Luz Alicia González Hernández
Jaime Federico Andrade Villanueva
Pedro Martinez Ayala
Rodolfo Ismael Cabrera Silva
Karina Sánchez Reyes

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1669148

260 views

Correction

Accepted on 15 Sep 2025

Correction: The role of protein S-acylation in vascular injury associated with metabolic disorders

in Diabetes: Molecular Mechanisms

Yayun Wang
Wenhui Zhu
Wenfan Wang
Jiayi Zhang
Dongsen Hu
Huanmeng Shao
Yingtong zhou
Shan Wang
Linhua Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1704241

138 views

Original Research

Accepted on 15 Sep 2025

Development of targeted drugs for diabetic retinopathy using Mendelian randomized pharmacogenomics

in Diabetes: Molecular Mechanisms

Guodan Liu
Miao Tian
Xinge Li
Xichen Wang
Songhao Zhang
Gali Bai
Xuyang Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1632691

140 views

Original Research

Accepted on 15 Sep 2025

Alterations of oral microbiota and cytokines profile in children and young adults with type 1 diabetes

in Diabetes: Molecular Mechanisms

Luana Aldegheri
Eulalia Catamo
Nunzia Zanotta
Giuseppina Campisciano
Carolina Cason
Andrea Conti
Chiara Cipullo
Milena Cadenaro
Gianluca Tornese
Chiara Navarra

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1629185

142 views

Original Research

Published on 15 Sep 2025

Adipose tissue quantity, distribution and pathology and its relationship with type-2 diabetes, insulin resistance and other clustering disease risk in South Asians: a cross-sectional study

in Diabetes: Molecular Mechanisms

Aditya Saxena
Sanjay Saran
Praveen Choudhary
Balram Sharma
Shalu Gupta
Rajendra Mandia
Ramesh C. Banshiwal
Ravinder Kumar Lamoria
Anurag Dhakad
Utkarsh Raj

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1622732

603 views

Original Research

Published on 11 Sep 2025

Triglycerides as a mediator in the hyperuricemia-diabetes link: insights from a hypertensive Chinese population

in Diabetes: Molecular Mechanisms

Dan Lu
Xiaowen Ou
Tingjun Wang
Guoyan Xu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1645766

626 views