Frontiers in Immunology

Original Research

Published on 01 Dec 2025

Commensal Staphylococci attenuate Staphylococcus aureus skin colonization and inflammation via AHR-dependent signaling

in Microbial Immunology

Jule Riebelmann
Nicole Kienzle
Birgit Sauer
Birgit Schittek

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726557

916 views

Mini Review

Published on 01 Dec 2025

From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS

in Molecular Innate Immunity

Yingshi Bao
Zixuan Chen
Yutong Su
Tingting Guo
Huaping Du
Xianjun Jia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682030

866 views

Original Research

Published on 01 Dec 2025

Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization and in vivo evidence

in Microbial Immunology

Aling Tang
Zhimin Gong
Yi Shi
Weizhen Zhang
Mingming Jin
Lichao Sun
Wei Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674678

846 views

Original Research

Published on 01 Dec 2025

Pan-cancer multi-omics analysis of CCT4 in tumor progression and cancer immunity, with focus on lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Yonghui Wu
Zhenpeng Wu
Junjie Wen
Desheng Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714837

667 views

Opinion

Published on 01 Dec 2025

Targeting the role played by microbiota and adaptive immunity within autoimmune disease complexity

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Anders Bredberg
Katrine R. Nermo
Gunnel Henriksson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718417

706 views

Original Research

Published on 01 Dec 2025

Intestinal microbiota regulates naïve lymphocyte migration in Peyer’s patches

in Mucosal Immunity

Johanna Kabbert
Anne Kaminski
Oliver Pabst
Milas Ugur

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717788

808 views

Review

Published on 01 Dec 2025

Pathogen-induced hijacking of host SUMOylation: from molecular mechanisms and prospects for therapeutic modulation

in Microbial Immunology

Sandhya Padmakumar
Aravind Madhavan
Bipin G. Nair
Geetha B. Kumar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686880

622 views

Mini Review

Published on 01 Dec 2025

Shaping the glioblastoma microenvironment to enhance CAR-NK immunotherapy

in Cancer Immunity and Immunotherapy

Emily Tang
Jake Y. Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681966

754 views

Original Research

Published on 01 Dec 2025

LASSO-empowered nomogram integrating nutritional-inflammatory-tumor characteristics predicts immunotherapy outcomes in advanced HCC: Large retrospective cohort

in Cancer Immunity and Immunotherapy

Shuifang Hu
Mingcong Xu
Shuping Li
Wei Chen
Zhenwei Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626940

547 views

Original Research

Published on 01 Dec 2025

Overall survival according to time-of-day of combined immuno-chemotherapy for advanced gastric cancer: a propensity score-matched analysis

in Cancer Immunity and Immunotherapy

Chong Cheng
Xiaqin Cheng
Tiejun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653218

699 views

Original Research

Published on 01 Dec 2025

In silico design of novel precision vaccine targeting sclerostin epitopes for osteoporosis prevention and treatment

in Vaccines and Molecular Therapeutics

Jianzhou Luo
Tailin Wu
Bin Guan
Lin Li
Zili Yang
Huiren Tao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644437

735 views

Original Research

Published on 01 Dec 2025

Impact of anti-TB drugs on modulations of T-cell-receptor-mediated signaling events in TB pleurisy patients

in Microbial Immunology

Bhawna Sharma
Beenu Joshi
Santosh Kumar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645200

695 views

Original Research

Published on 01 Dec 2025

Reduced CD40 expression in B cell subsets of individuals with radiologically isolated syndrome

in Multiple Sclerosis and Neuroimmunology

Christian W. Keller
Kerstin Stein
Andreu Vilaseca
Luisa M. Villar
Gary Álvarez-Bravo
Maria Protopapa
Josef Shin
Nicolás Fissolo
José Enrique Martínez-Rodríguez
Ana Quiroga-Varela

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680233

663 views

Original Research

Published on 01 Dec 2025

Prognostic and therapeutic implications of disulfidptosis-related genes in multiple myeloma

in Cancer Immunity and Immunotherapy

Yunke Zang
Peipei Zhou
Haotian Dong
Jingfei Wang
Rongxuan Cao
Guimao Yang
Qianqian Wu
Yanhua Sun
Yanli Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652179

467 views

Case Report

Published on 01 Dec 2025

Classical complement activation in light and heavy chain deposition disease with acquired cutis laxa and bronchiolitis obliterans: a case report of monoclonal gammopathy of clinical significance

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yuxiong Chen
Yue Fan
Shoudong Yang
Haoyuan Cui
Wei Ye
Wenling Ye
Yubing Wen
Junling Zhuang
Ping Wang
Donglai Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718342

588 views

Original Research

Published on 01 Dec 2025

Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury

in Inflammation

Sean O’Leary
Anesh Prasai
Ariadna Robledo
Christopher Thang
Ye Wang
Rahul R. Deshpande
William K. Russell
Andrew J. Murton
Steven E. Wolf
Amina El Ayadi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709256

875 views

Original Research

Published on 01 Dec 2025

Conformational stability of hemocyanins regulates their lysosomal and proteasomal degradation, influencing their pro-inflammatory effects on mammalian antigen-presenting cells

in Antigen Presenting Cell Biology

Michelle L. Salazar
Claudia d’Alençon
Diego Díaz-Dinamarca
Javier Bustamante
Byron Castillo
Alejandra Alvarado
Fabián Salazar
Augusto Manubens
María Inés Becker

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603070

727 views

Editorial

Published on 01 Dec 2025

Editorial: Early phase clinical trials for the development of novel immunotherapeutic anti-cancer agents

in Cancer Immunity and Immunotherapy

Agnese Losurdo
Anastasia Lalioti
Angelo Dipasquale
Matteo Simonelli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1750018

631 views

Review

Published on 01 Dec 2025

Unraveling the immune response in optic nerve injury: implications for retinal ganglion cell protection

in Inflammation

Kexin Xu
Lu Yu
Ningzhi Zhang
Min Dong
Yiqiao Xing
Ning Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671438

585 views

Original Research

Published on 01 Dec 2025

Estradiol enhances B cell humoral immune responses against genital herpes simplex virus type 2 in mice through an IL-17 dependant pathway

in Mucosal Immunity

M. Firoz Mian
Ramtin Ghasemi
Puja Bagri
Joshua J. C. McGrath
Danya Thayaparan
Maysa Niazy
Denis P. Snider
Charu Kaushic

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691163

1,002 views

Original Research

Published on 01 Dec 2025

Integrative multi-omics analysis identifies a PTM-related immune signature and IRF9 as a driver in ccRCC

in Cancer Immunity and Immunotherapy

Zixiang Li
Xun Li
Simeng Hu
Shan Jiang
Junqi Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707375

800 views

Review

Published on 01 Dec 2025

The significance of trained immunity in cancer

in Cancer Immunity and Immunotherapy

Junxing Qu
Xinya Guo
Xinru Wang
Huiwen Meng
Peizhi Li
Zhiheng Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665099

861 views

Case Report

Published on 01 Dec 2025

A case report of advanced pancreatic neuroendocrine carcinoma with Ki67 80%, CPS 0, and pMMR achieving durable complete response for over 7 years after combination immunotherapy

in Cancer Immunity and Immunotherapy

Weiqiang Fan
Hui Xu
Yating Wu
Hang Li
Yonghai Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682148

625 views

Original Research

Published on 01 Dec 2025

Anti-gallbladder cancer activities and toxicity studies of glycyrrhetinic acid derivative as a novel PPARγ agonist

in Cancer Immunity and Immunotherapy

Min Liu
Haizhang Ma
Gaozhong Xiong
Mei Qi
Yuan Xia
Yunxue Zhao
Chunyan Ji
Juan Sun
Tao Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704994

715 views

48,462 articles

articles

Commensal Staphylococci attenuate Staphylococcus aureus skin colonization and inflammation via AHR-dependent signaling

From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS

Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization and in vivo evidence

Pan-cancer multi-omics analysis of CCT4 in tumor progression and cancer immunity, with focus on lung adenocarcinoma

Targeting the role played by microbiota and adaptive immunity within autoimmune disease complexity

Intestinal microbiota regulates naïve lymphocyte migration in Peyer’s patches

Pathogen-induced hijacking of host SUMOylation: from molecular mechanisms and prospects for therapeutic modulation

Shaping the glioblastoma microenvironment to enhance CAR-NK immunotherapy

LASSO-empowered nomogram integrating nutritional-inflammatory-tumor characteristics predicts immunotherapy outcomes in advanced HCC: Large retrospective cohort

Overall survival according to time-of-day of combined immuno-chemotherapy for advanced gastric cancer: a propensity score-matched analysis

In silico design of novel precision vaccine targeting sclerostin epitopes for osteoporosis prevention and treatment

Impact of anti-TB drugs on modulations of T-cell-receptor-mediated signaling events in TB pleurisy patients

Reduced CD40 expression in B cell subsets of individuals with radiologically isolated syndrome

Prognostic and therapeutic implications of disulfidptosis-related genes in multiple myeloma

Classical complement activation in light and heavy chain deposition disease with acquired cutis laxa and bronchiolitis obliterans: a case report of monoclonal gammopathy of clinical significance

Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury

Conformational stability of hemocyanins regulates their lysosomal and proteasomal degradation, influencing their pro-inflammatory effects on mammalian antigen-presenting cells

Editorial: Early phase clinical trials for the development of novel immunotherapeutic anti-cancer agents

Unraveling the immune response in optic nerve injury: implications for retinal ganglion cell protection

Estradiol enhances B cell humoral immune responses against genital herpes simplex virus type 2 in mice through an IL-17 dependant pathway

Integrative multi-omics analysis identifies a PTM-related immune signature and IRF9 as a driver in ccRCC

The significance of trained immunity in cancer

A case report of advanced pancreatic neuroendocrine carcinoma with Ki67 80%, CPS 0, and pMMR achieving durable complete response for over 7 years after combination immunotherapy

Anti-gallbladder cancer activities and toxicity studies of glycyrrhetinic acid derivative as a novel PPARγ agonist