Frontiers in Immunology

Original Research

Published on 02 Jun 2025

Conversion study of hepatocellular carcinoma using HAIC combined with lenvatinib and PD-1/L1 immunotherapy under the guidance of BCLC staging

in Cancer Immunity and Immunotherapy

Weihao Zhang
Xiaohui Zhao
Wei Gao
Tongguo Si
Qiang Zou
Xueling Yang
Wenge Xing
Haipeng Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596864

1,420 views

Original Research

Published on 02 Jun 2025

The comparison of efficacy and safety between cadonilimab (PD-1/CTLA-4) and anti-PD-1 inhibitors in patients with recurrent or metastatic cervical cancer: a retrospective real-world study

in Cancer Immunity and Immunotherapy

Baoyue Pan
He Huang
Ting Wan
Qidan Huang
Shanyang He
Shijie Xu
Siyu Chen
Jiaxin Yin
Jundong Li
Min Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582299

1,550 views

Editorial

Published on 02 Jun 2025

Editorial: Immune responses at barrier tissues: insights from synthetic biology in therapeutics, diagnostics, mechanisms, and beyond

in Mucosal Immunity

Siheng Chao
Naoki Iwanaga
Hernan Felipe Peñaloza
Nicola Ivan Lorè
Kong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621688

874 views

Mini Review

Published on 02 Jun 2025

Lymphatic dissemination of HPV-positive oropharyngeal squamous cell carcinoma: underlying mechanisms and treatment innovations

in Cancer Immunity and Immunotherapy

Xinyu Li
Hui Qiu
Qiuji Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601572

1,578 views

Editorial

Published on 02 Jun 2025

Editorial: Community series in emerging insights in controlling autoimmunity, volume II

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Lorenza Bruno
Dimitrios Bogdanos
Maria Maslinska
Carlo Perricone

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613858

896 views

Original Research

Published on 02 Jun 2025

Correlation between increased total serum IgE levels and clinical features in alopecia areata patients

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yijie Sun
Shuang Xu
Yujing Zhang
Yuxin Wang
Jianzhong Zhang
Xiangqian Li
Cheng Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581976

1,174 views

Original Research

Published on 02 Jun 2025

IFN-γ gene polymorphisms +874 T/A and +2109 A/G are associated with the serofast state after early syphilis treatment: a prospective observational study

in Inflammation

Konrad Kaminiów
Martyna Kiołbasa
Maciej Pastuszczak

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602527

896 views

Case Report

Published on 02 Jun 2025

Case Report: Unilateral relapsing primary central nervous system vasculitis—expanding the phenotype

in Multiple Sclerosis and Neuroimmunology

Turlough Montague
Jenny Han
Emily Cheung
James Drummond
Hwei Choo Soh
Jeannette Lechner-Scott
John Parratt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1502022

1,065 views

Review

Published on 02 Jun 2025

Role of interleukin-16 in human diseases: a novel potential therapeutic target

in Cytokines and Soluble Mediators in Immunity

Timothy B. Niewold
Julia S. Lehman
Iva Gunnarsson
Alexander Meves
Vilija Oke

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524026

1,752 views

Systematic Review

Published on 02 Jun 2025

Unravelling the link between chronic inflammation and primary hyperparathyroidism: a systematic review

in Inflammation

Ana Gheorghe-Milea
Oana Stănoiu-Pînzariu
Carmen Emanuela Georgescu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563967

1,278 views

Original Research

Published on 02 Jun 2025

Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management

in Primary Immunodeficiencies

Nourhen Agrebi
Rafah Mackeh
Mohamed Alsabbagh
Asha Elmi
Amnah A. Al-Marri
Satanay Z. Hubrack
Saleema C. Purayil
Mohammed Yousuf Karim
Amel Hassan
Bernice Lo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594636

1,185 views

Systematic Review

Published on 02 Jun 2025

Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review

in Systems Immunology

Xianghui Zhao
Peiying Lv
Zixing Cai
Jun Dong
Wenxiang Chen
Liang Sun
Ruiyue Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579924

2,097 views

Original Research

Published on 30 May 2025

Is adiponectin involved in morphea pathogenesis? – first observational study

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Adriana Polańska
Aleksandra Wiktoria Bratborska
Michał J. Kowalczyk
Ryszard Żaba
Aleksandra Dańczak-Pazdrowska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588439

1,512 views

Original Research

Published on 30 May 2025

Impact of body composition on pathological response to neoadjuvant immunotherapy in dMMR/MSI-H colorectal cancer

in Cancer Immunity and Immunotherapy

Ziyang Zeng
Jian Zhou
Weili Zhang
Jianhong Peng
Yuan Li
E-er-man-bie-ke Jin-si-han
Hao Wang
Shaopu Lian
Cheng Feng
Chuanmiao Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589869

1,508 views

Original Research

Published on 30 May 2025

KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification

in Systems Immunology

Nan Zhang
Shishun Zhao
Runze Wu
Xizi Luo
Ming Yang
Zecheng Chang
Jianting Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602907

1,051 views

Original Research

Published on 30 May 2025

Immunogenomic characteristics and prognostic implications of terminally exhausted CD8+ T cells in colorectal cancers

in Cancer Immunity and Immunotherapy

Ji-Ae Lee
Hye Eun Park
Dae-Won Lee
Sae-Won Han
Tae-You Kim
Seung-Yong Jeong
Kyu Joo Park
Jeong Mo Bae
Gyeong Hoon Kang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601188

1,296 views