Frontiers in Immunology | B Cell Biology

Review

Published on 18 Aug 2025

B cell depletion as a therapeutic strategy for neuromyelitis optica spectrum disorder: rationale, evidence, and challenges

in B Cell Biology

Hirofumi Ochi
Satoru Nakamura
Jin Nakahara

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635989

5,689 views

Original Research

Published on 15 Aug 2025

Comparative analysis of CDR3 length-dependent patterns in VHHs

in B Cell Biology

Lu Zhang
Tianyu Yang
Yao Zhang
Jiahui Yan
Jiaguo Li
Wenfeng Xu
Weimin Zhu
Xinhao Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647230

4,164 views
2 citations

Editorial

Published on 13 Aug 2025

Editorial: Unraveling mechanisms and implications of anti-RBC antibodies in transfusion medicine

in B Cell Biology

Krystalyn E. Hudson
David R. Gibb

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671343

1,612 views

Review

Published on 08 Aug 2025

B cell development: transcriptional regulation and immunological mechanisms in homeostasis

in B Cell Biology

Jorge Gómez-Manríquez
Jorge Hernández-Bello
José Francisco Muñoz-Valle
Sonia Sifuentes-Franco
Omar Graciano-Machuca
José Javier Morales-Núñez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593338

9,196 views

Review

Published on 07 Aug 2025

The role of B lymphocyte subsets in nephrotic syndrome: functions, mechanisms, clinical significance and future perspectives

in B Cell Biology

Yuheng Liao
Haofei Hu
Qijun Wan
Haiying Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598197

5,110 views
1 citation

Original Research

Published on 06 Aug 2025

Investigation into the prognostic factors of early recurrence and progression in previously untreated diffuse large B-cell lymphoma and a statistical prediction model for POD12

in B Cell Biology

Ke Lian
Wenyao Zhu
Zhihui Hu
Fang Su
CaiXia Xu
Hui Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539924

2,069 views

Original Research

Published on 01 Aug 2025

Clone-specific residue changes at multiple positions are associated with amyloid formation by antibody light chains

in B Cell Biology

Gareth J. Morgan
Tatiana Prokaeva

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622207

1,920 views
1 citation

Original Research

Published on 31 Jul 2025

Treatment with intravenous immunoglobulin modulates coagulation- and complement-related pathways in COVID-19 patients

in B Cell Biology

Dominic McGrosso
Jessica Raygoza
Avnee J. Kumar
Michael T. Y. Lam
Laura A. Barnes
Sophia Karandashova
Alexia Perryman
Matthew Geriak
Mazen F. Odish
Nicole G. Coufal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623309

3,389 views
1 citation

Original Research

Published on 30 Jul 2025

Engineered human B cells targeting tumor-associated antigens exhibit antigen presentation and antibody-mediated functions

in B Cell Biology

Alexander Boucher
Courtney Anderson
Rochelle Hinman
Molly Kindschuh
Jeremy Fung
Tiansu Wang
Isabella Klooster
Elise Kim
Caroline Roth
Michael Vander Oever

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621222

5,726 views
6 citations

Correction

Published on 22 Jul 2025

Correction: B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry

in B Cell Biology

Gregg J. Silverman
Abhimanyu N. Amarnani
Arnaldo A. Arbini
Angie Kim
Hannah Kopinsky
David Fenyo
Ilya Kister

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649409

1,371 views

Original Research

Published on 22 Jul 2025

Adenovectored RSV prefusion glycoprotein + soluble glycoprotein combination immunization establishes persistent opsonophagocytic antibody response through IgG3

in B Cell Biology

Xin Tong
Ross Blanc
Deniz Cizmeci
Hadar Malca
Jaewon Kang
Christy Comeaux
Benoit Callendret
Arangassery Rosemary Bastian
Mehak Zahoor Khan
Galit Alter

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609779

3,985 views
1 citation

Original Research

Published on 18 Jul 2025

Mouse B cells engineered to express an anti-HPV antibody elicit anti-tumor T cell responses

in B Cell Biology

Michal Guberman Bracha
Guy Biber
Natalie Zelikson
Sharon Shavit
Roy Avraham
Yaron Vagima
Débora Rosa Bublik
Yael Katz
Adi Barzel
Leah Natasha Klapper

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613879

4,263 views
1 citation

Review

Published on 01 Jul 2025

A paradigm shift in simulating affinity maturation to elicit broadly neutralizing antibodies

in B Cell Biology

Fahsai Nakarin
Kayla G. Sprenger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627674

4,507 views

Original Research

Published on 01 Jul 2025

Low nanomolar affinity to major grass pollen allergen Phl p 5 as achieved in an unmutated human antibody-lineage ancestor

in B Cell Biology

Mattias Essén
Eric Franciskovic
Céleste Sele
Magdalena Godzwon
Mats Ohlin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600778

2,262 views
1 citation

Original Research

Published on 10 Jun 2025

B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry

in B Cell Biology

Gregg J. Silverman
Abhimanyu N. Amarnani
Arnaldo A. Arbini
Angie Kim
Hannah Kopinsky
David Fenyo
Ilya Kister

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590165

3,347 views

Original Research

Published on 04 Jun 2025

Elucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay

in B Cell Biology

Cary M. Looney
Axel Ducret
Guido Steiner
Karen Dernick
Katharina Hartman
Michel Siegel
Timothy Hickling
Alex Odermatt
Céline Marban-Doran

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589483

4,168 views
1 citation

Original Research

Published on 03 Jun 2025

Phosphatidylcholine-specific B cells are enriched among atypical CD11chigh and CD21low memory B cells in antiphospholipid syndrome

in B Cell Biology

Eduard Nitschke
Van Duc Dang
Hector Rincon-Arevalo
Franziska Szelinski
Jacob Ritter
Eva Schrezenmeier
Tobias Alexander
Tuan Anh Le
Yidan Chen
Annika Wiedemann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585953

4,021 views
1 citation

Original Research

Published on 16 May 2025

Engineered sequestrins inhibit aggregation of pathogenic alpha-synuclein mutants

in B Cell Biology

Linnea Charlotta Hjelm
Wojciech Paslawski
Christofer Lendel
Siri Flemming Svedmark
Per Svenningsson
Stefan Ståhl
Hanna Lindberg
John Löfblom

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574755

2,729 views

Original Research

Published on 02 May 2025

B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort

in B Cell Biology

Matthew Moll
Zhonghui Xu
Adel Boueiz
Min Hyung Ryu
Edwin K. Silverman
Michael H. Cho
Craig P. Hersh
Maor Sauler
Francesca Polverino
Gregory L. Kinney

Frontiers in Immunology

doi 10.3389/fimmu.2025.1508786

4,536 views
2 citations

Case Report

Published on 01 May 2025

Efficacy of Telitacicept in treating IgA vasculitis nephritis: a two-case report

in B Cell Biology

Shuang-xi Li
Rui-kang Hu
De-liang Kong
Jing Xu
Qi Bian
Zhi-Yong Guo
Xiao-bin Mei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564242

4,536 views
2 citations

Original Research

Published on 28 Apr 2025

Mimicking immune complexes for efficient antibody responses

in B Cell Biology

Jonathan Schönfelder
Omar El Ayoubi
Oles Havryliuk
Rüdiger Groß
Alina Seidel
Tamam Bakchoul
Jan Münch
Hassan Jumaa
Corinna S. Setz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570487

3,613 views

Original Research

Published on 17 Apr 2025

Regulatory T cell epitope content in human antibodies decreases during maturation

in B Cell Biology

Andres H. Gutierrez
Frances E. Terry
Amy S. Rosenberg
William D. Martin
Anne S. De Groot

Frontiers in Immunology

doi 10.3389/fimmu.2025.1535826

6,771 views

Original Research

Published on 17 Apr 2025

CD19+ B cell depletion: a novel strategy to alleviate ischemic stroke damage

in B Cell Biology

Yu Xu
Jing Peng
Yizhong Yan
Min Gao
HongJing Zang
Lamei Cheng
Yu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528471

3,950 views

Original Research

Published on 28 Mar 2025

Early-life homeostatic differentiation of thymus-resident B cells into memory B cells

in B Cell Biology

Justine Castañeda
Lilian Poblete
Mariana V. Rosemblatt
Daniela Sauma
Mario Rosemblatt
María Rosa Bono
Sarah Nuñez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567788

3,530 views
1 citation

1,037 articles

articles

B cell depletion as a therapeutic strategy for neuromyelitis optica spectrum disorder: rationale, evidence, and challenges

Comparative analysis of CDR3 length-dependent patterns in VHHs

Editorial: Unraveling mechanisms and implications of anti-RBC antibodies in transfusion medicine

B cell development: transcriptional regulation and immunological mechanisms in homeostasis

The role of B lymphocyte subsets in nephrotic syndrome: functions, mechanisms, clinical significance and future perspectives

Investigation into the prognostic factors of early recurrence and progression in previously untreated diffuse large B-cell lymphoma and a statistical prediction model for POD12

Clone-specific residue changes at multiple positions are associated with amyloid formation by antibody light chains

Treatment with intravenous immunoglobulin modulates coagulation- and complement-related pathways in COVID-19 patients

Engineered human B cells targeting tumor-associated antigens exhibit antigen presentation and antibody-mediated functions

Correction: B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry

Adenovectored RSV prefusion glycoprotein + soluble glycoprotein combination immunization establishes persistent opsonophagocytic antibody response through IgG3

Mouse B cells engineered to express an anti-HPV antibody elicit anti-tumor T cell responses

A paradigm shift in simulating affinity maturation to elicit broadly neutralizing antibodies

Low nanomolar affinity to major grass pollen allergen Phl p 5 as achieved in an unmutated human antibody-lineage ancestor

B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry

Elucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay

Phosphatidylcholine-specific B cells are enriched among atypical CD11chigh and CD21low memory B cells in antiphospholipid syndrome

Engineered sequestrins inhibit aggregation of pathogenic alpha-synuclein mutants

B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort

Efficacy of Telitacicept in treating IgA vasculitis nephritis: a two-case report

Mimicking immune complexes for efficient antibody responses

Regulatory T cell epitope content in human antibodies decreases during maturation

CD19+ B cell depletion: a novel strategy to alleviate ischemic stroke damage

Early-life homeostatic differentiation of thymus-resident B cells into memory B cells