Frontiers in Immunology | Cytokines and Soluble Mediators in Immunity

Original Research

Accepted on 16 Sep 2025

Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor's role in recurrent spontaneous abortion

in Cytokines and Soluble Mediators in Immunity

Weixu Ma
Zhongjia Gu
Qiwang Lin
Mingzhu Cao
Xin Li
Hongyan Li
Yue Lin
Han Lin
Junmin Zhong
Mengchang Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659251

Original Research

Accepted on 16 Sep 2025

A crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS

in Cytokines and Soluble Mediators in Immunity

Louise Nuyttens
Marah Heyerick
Maxime Roes
Elise Moens
Céline Van Dender
Charlotte Wallaeys
Tino Hochepied
Steven Timmermans
Jolien Vandewalle
Claude Libert

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652516

Review

Accepted on 16 Sep 2025

Cytokines in Sepsis: A Critical Review of the Literature on Systemic Inflammation and Multiple Organ Dysfunction

in Cytokines and Soluble Mediators in Immunity

Roberta Vella
Diego Panci
Francesco Carini
Ginevra Malta
SALVATORE VIENI
Sabrina David
Giuseppe Davide Albano
Maria Puntarello
Stefania Zerbo
Antonina Argo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682306

Original Research

Accepted on 12 Sep 2025

IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis

in Cytokines and Soluble Mediators in Immunity

Jiezhong Deng
Jun Gu
Xiaoshan Gong
Hao Tang
Yuyi Cai
Yusheng Yang
Shi-Wu Dong
Chunrong Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630253

862 views

Original Research

Published on 12 Sep 2025

Longitudinal evaluation of T-cell responses to Pfizer-BioNTech and Janssen SARS-CoV-2 vaccines as boosters in Ghanaian adults

in Cytokines and Soluble Mediators in Immunity

Frank Osei
Kekeli Korshi Tudzi
Isaac Otieno Othol
Selorm Philip Segbefia
Diana Ahu Prah
Evans Nii Armah-Vedjesu
Abigail Naa Adjorkor Pobee
Oscar Nii Otto Darko
Theophilus Brenko
Doreen Teye-Adjei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643083

1,382 views

Review

Published on 12 Sep 2025

Research progress on the mechanisms of interleukin and chemokine families in driving calcium oxalate nephrolithiasis formation

in Cytokines and Soluble Mediators in Immunity

Fujie Liang
Fuyou Guo
Runjun Liu
Xiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651003

905 views

Original Research

Published on 12 Sep 2025

Low rather than high interleukin-6 levels are associated with immune-related adverse events in cancer patients treated with immune checkpoint inhibitors

in Cytokines and Soluble Mediators in Immunity

Iñigo Les
David de Haedo
Mireia Martínez
Berta Ibáñez-Beroiz
Amaia Moreno
Ibone de Elejoste
Ana Campillo-Calatayud
Inés Pérez-Francisco
María Cabero
Iñaki Elejalde

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677778

657 views

Review

Published on 10 Sep 2025

Role of depression-mediated alterations in pro-inflammatory cytokines in carcinogenesis

in Cytokines and Soluble Mediators in Immunity

Rui Cao
Heguo Jiang
Ping Chen
Chunhua Dai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659153

1,371 views

Original Research

Published on 05 Sep 2025

Inhibition of IL-27 signaling regulates chemokine levels and sustains CXCR2 receptor expression on mononuclear cells to improve disease outcomes during gram-negative neonatal sepsis

in Cytokines and Soluble Mediators in Immunity

Madhavi Annamanedi
Jordan K. Vance
Cory M. Robinson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653355

1,335 views

Review

Published on 05 Sep 2025

The interplay between mesenchymal stem cells and the immune microenvironment in rotator cuff tendon-to-bone healing: current progress and future directions

in Cytokines and Soluble Mediators in Immunity

Dong Li
Yujia Zou
Yuanting Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661340

968 views

Mini Review

Published on 04 Sep 2025

Mini review: Interleukin-32 as a key mediator of type 1 diabetes pathogenesis

in Cytokines and Soluble Mediators in Immunity

James A. Pearson
Stephanie J. Hanna

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641698

915 views

Review

Published on 03 Sep 2025

Decoding STAT3: a new frontier in understanding and treating hyperoxic lung injury

in Cytokines and Soluble Mediators in Immunity

Wulan Li
Qian Liu
Wenyan Xiong
Xu Zhong
Lei Tian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657823

851 views

Original Research

Published on 03 Sep 2025

Mechanism of IFITM1 regulating epidural scar hyperplasia after laminectomy through SMAD3/CBR4 pathway

in Cytokines and Soluble Mediators in Immunity

Haoran Wang
Zekai Zhu
Jun Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628970

667 views

Original Research

Accepted on 02 Sep 2025

Extracellular vesicles of patients with acute-on-chronic liver failure induce mitochondrial dysfunction in T cells

in Cytokines and Soluble Mediators in Immunity

Mona-May Langer
Sabrina Guckenbiehl
Alina Bauschen
Helena Stadler
Farnusch Kaschani
Markus Kaiser
Bernd Walkenfort
Heiner Wedemeyer
Christian M Lange

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656692

267 views

Original Research

Published on 01 Sep 2025

NUPA10hd-immortalized and genetically engineered progenitors allow studying dendritic cell immune functions

in Cytokines and Soluble Mediators in Immunity

Guerric P. B. Samson
Nadine Anslinger
Daniel F. Legler
Daniela Finke

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658429

1,320 views

Review

Accepted on 28 Aug 2025

CCR10: A Comprehensive Review of Its Function, Phylogeny, Role in Immune Cell Trafficking and Disease Pathogenesis

in Cytokines and Soluble Mediators in Immunity

Amanda Lopes Willuveit
Ana Carolina Buzzo Stefanini
Tais Aparecida Matozo de Souza
Luciana Cavalheiro Marti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599277

711 views