Frontiers in Immunology | Systems Immunology

Original Research

Published on 08 Apr 2025

Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings

in Systems Immunology

Tianmeng Chen
Julia Hughes
Alyssa Gregory
Julia Conroy
Patricia Loughran
Jinming Song
Wei Chen
Timothy Billiar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565211

918 views

Original Research

Accepted on 07 Apr 2025

Interpretable Machine Learning Algorithms Reveals Gut Microbiome Features Associated with Atopic Dermatitis

in Systems Immunology

Jingtai Ma
yiting fang
shiqi li
Lilian Zeng
Siyi Chen
Zhifeng Li
Guiyuan Ji
Xing-Fen Yang
wei wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528046

139 views

Review

Published on 02 Apr 2025

TREM2+ macrophages: a key role in disease development

in Systems Immunology

Xinxin Wang
Yunhan Wang
Lei Yang
Yi Zhang
Li Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550893

1,440 views

Review

Published on 31 Mar 2025

Oral and transdermal administration of lipopolysaccharide safely enhances self-healing ability through the macrophage network

in Systems Immunology

Gen-Ichiro Soma
Masataka Oda
Vindy Tjendana Tjhin
Chie Kohchi
Hiroyuki Inagawa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563484

976 views

Review

Published on 31 Mar 2025

Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review

in Systems Immunology

Siyu He
Ziyue Wang
Yinan Zhu
Mingfang Sun
Xuyong Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1473817

1,107 views

Original Research

Published on 26 Mar 2025

Integrating machine learning and multi-omics analysis to reveal nucleotide metabolism-related immune genes and their functional validation in ischemic stroke

in Systems Immunology

Tianzhi Li
Xiaojia Kang
Sijie Zhang
Yihan Wang
Jinshan He
Hongyan Li
Chen Shao
Jingsong Kang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561544

1,611 views

Original Research

Published on 24 Mar 2025

A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma

in Systems Immunology

Jiale Fang
Siyuan Yu
Wei Wang
Cheng Liu
Xiaojia Lv
Jiaqi Jin
Xiaomin Han
Fang Zhou
Yukun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524120

1,473 views

Original Research

Published on 21 Mar 2025

Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning

in Systems Immunology

Junyang Ma
Shufu Hou
Xinxin Gu
Peng Guo
Jiankang Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533959

1,477 views

Original Research

Published on 21 Mar 2025

Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup

in Systems Immunology

Piia Karisola
Mari Kanerva
Aki Vuokko
Helena Liira
Shuyuan Wang
Kirsi Kvarnström
Mikko Varonen
Hille Suojalehto
Harri Alenius

Frontiers in Immunology

doi 10.3389/fimmu.2025.1500997

850 views

Editorial

Published on 18 Mar 2025

Editorial: Spatial immunology of tissue microenvironments

in Systems Immunology

Roslyn A. Kemp
Felix Marsh-Wakefield

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584850

664 views

Correction

Published on 13 Mar 2025

Corrigendum: Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages

in Systems Immunology

Wenyu Fu
Qinqin Xie
Pengfei Yu
Shuang Liu
Lingyao Xu
Xiaowei Ye
Wei Zhao
Qishan Wang
Yuchun Pan
Zhe Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588642

439 views

Original Research

Published on 12 Mar 2025

Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer

in Systems Immunology

Teng Wang
Zhaoming Chen
Wang Wang
Heng Wang
Shenglong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1556386

1,701 views

Correction

Published on 07 Mar 2025

Corrigendum: Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

in Systems Immunology

Aliakbar Hasankhani
Abolfazl Bahrami
Negin Sheybani
Behzad Aria
Behzad Hemati
Farhang Fatehi
Hamid Ghaem Maghami Farahani
Ghazaleh Javanmard
Mahsa Rezaee
John P. Kastelic

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572273

452 views

Methods

Published on 28 Feb 2025

OnmiMHC: a machine learning solution for UCEC tumor vaccine development through enhanced peptide-MHC binding prediction

in Systems Immunology

Fangfang Jian
Haihua Cai
Qushuo Chen
Xiaoyong Pan
Weiwei Feng
Ye Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550252

1,013 views

Original Research

Published on 28 Feb 2025

Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages

in Systems Immunology

Wenyu Fu
Qinqin Xie
Pengfei Yu
Shuang Liu
Lingyao Xu
Xiaowei Ye
Wei Zhao
Qishan Wang
Yuchun Pan
Zhe Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1530214

1,192 views

Original Research

Published on 25 Feb 2025

In-depth immunochemical characterization of the serum antibody response using a dual-titration microspot assay

in Systems Immunology

Ágnes Kovács
Zoltán Hérincs
Krisztián Papp
Jakub Zbigniew Kaczmarek
Daniel Nyberg Larsen
Pernille Stage
László Bereczki
Eszter Ujhelyi
Tamás Pfeil
József Prechl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1494624

751 views