Frontiers in Immunology | Systems Immunology

Systematic Review

Published on 02 Jun 2025

Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review

in Systems Immunology

Xianghui Zhao
Peiying Lv
Zixing Cai
Jun Dong
Wenxiang Chen
Liang Sun
Ruiyue Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579924

647 views

Original Research

Published on 30 May 2025

KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification

in Systems Immunology

Nan Zhang
Shishun Zhao
Runze Wu
Xizi Luo
Ming Yang
Zecheng Chang
Jianting Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602907

611 views

Editorial

Published on 30 May 2025

Editorial: Revolutionizing immunological disease understanding through single cell multi-omics technologies

in Systems Immunology

Ying Zhu
Veronica G. Anania
Jennie R. Lill
Zora Modrusan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628120

876 views

Original Research

Accepted on 29 May 2025

Developmental Immune Network of Airway Lymphocytes and Innate Immune Cells in Patients with Stable COPD

in Systems Immunology

Lanlan Liu
Mei Zhou
Shengwen Sun
Long Chen
Dehu Li
Jiaxi Lv
Rui Cheng
Jianchu Zhang
Jianghua Wu
Xianzhi Xiong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1614655

129 views

Original Research

Published on 29 May 2025

Transcriptional regulatory logic orchestrating lymphoid and myeloid cell fate decisions

in Systems Immunology

Rasoul Godini
Jingjing Yan
Michaël Chopin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1544483

786 views

Perspective

Published on 29 May 2025

Multi-physiology modeling of the immune system in the era of precision immunotherapy

in Systems Immunology

Sunghyun Hong
Kyemyung Park

Frontiers in Immunology

doi 10.3389/fimmu.2025.1548768

550 views

Original Research

Published on 27 May 2025

Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation

in Systems Immunology

Jingyi Hou
Lihan Wang
Naiqiang Zhu
Xueli Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543584

739 views

Original Research

Accepted on 26 May 2025

CAR-T cell therapy for glioblastoma: insight from mathematical modeling

in Systems Immunology

Magdalena Szafrańska-Łęczycka
Zuzanna Szymańska
Monika Joanna Piotrowska
Marek Bodnar
Urszula Foryś

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563829

225 views

Review

Accepted on 23 May 2025

Advanced Omics Approaches in Liver Transplant Settings: Current Applications and Future Prospectives

in Systems Immunology

Huijuan Wang
Yifeng Zhou
Lu Yu
Zhengtao Liu
Shusen Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564248

170 views

Original Research

Published on 21 May 2025

Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma

in Systems Immunology

Maria Eduarda de Castro
Gustavo Forlin de Siqueira
Jean Ferrante Mariano
Marina Malta Letro Kizys
Lucieli Ceolin
Fernando Augusto Soares
Rodrigo Natal
Humberto Carneiro
Rodrigo Nalio Ramos
Laura Sterian Ward

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579205

1,111 views

Original Research

Published on 20 May 2025

Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2

in Systems Immunology

N. S. Suneesh
Kishore Dhotre
Pratik Mahajan
Debashree Dass
Anwesha Banerjee
Nikhat J. Siddiqi
Abdul Malik
Manali Joshi
Abdul Arif Khan
Vijay Nema

Frontiers in Immunology

doi 10.3389/fimmu.2025.1586271

2,228 views

Original Research

Published on 16 May 2025

Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding

in Systems Immunology

Tingting Zhang
Laurie Baert
Neal W. Woodbury
Laimonas Kelbauskas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528524

1,110 views

Original Research

Published on 13 May 2025

Clinical and mechanistic relevance of high-dimensionality analysis of the paediatric sepsis immunome

in Systems Immunology

Dandan Pi
Judith Ju Ming Wong
Katherine Nay Yaung
Nicholas Kim Huat Khoo
Su Li Poh
Martin Wasser
Pavanish Kumar
Thaschawee Arkachaisri
Feng Xu
Herng Lee Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569096

1,036 views

Original Research

Published on 13 May 2025

Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing

in Systems Immunology

Hua Huang
Jiaze Ma
An Kang
Tianwei Guo
Wei Sun
Yan Xu
Lijiang Ji

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534768

1,577 views

Original Research

Published on 13 May 2025

Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus

in Systems Immunology

Jingjing Zhang
Ling Ma
Hanyin Deng
Wenqian Yi
Alim Tohtihan
Xiaojun Tang
Xiudi Wu
Xuebing Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580540

1,234 views

Original Research

Accepted on 12 May 2025

Integrative Bioinformatics and Machine Learning Approaches Reveal Oxidative Stress and Glucose Metabolism Related Genes as Therapeutic Targets and Drug Candidates in Alzheimer's Disease

in Systems Immunology

Fatima Noor
Sidra Aslam
Ignazio Piras
Cécilia Tremblay
Thomas G Beach
Geidy E Serrano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572468

277 views