Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Accepted on 13 Feb 2026

The Role of Large Immune Complexes in Anti-drug Antibody Development: A Case Study of Anti-SARS-CoV-2 Antibody Therapeutics and Co-administered mRNA vaccine

in Vaccines and Molecular Therapeutics

Susan C. Irvin
Zhiqiang Wang
Samit Ganguly
Deepanshu Choudhary
Minita Kanagaraj
Nina Liu
Flonza Isa
Zhongqing Will He
Hong Yan
Veronica Mas Casullo

Frontiers in Immunology

Original Research

Published on 13 Feb 2026

Novel BPI3Vc-vectored surface displayed fusion and hemagglutinin-neuraminidase antigens elicit broadly neutralizing antibodies in cattle

in Vaccines and Molecular Therapeutics

Huldah Sang
Tae Kim
Rakshith Kumar
Jayden McCall
Aloysius Abraham
Tsvetoslav Koynarski
Michelle Zajac
Karim W. Abdelsalam
Daniela Hernandez Muguiro
Katherine Bauer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702440

408 views

Correction

Published on 13 Feb 2026

Correction: Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses

in Vaccines and Molecular Therapeutics

Naomi Krickeberg
Hans-Georg Rammensee
Karin Schilbach

Frontiers in Immunology

doi 10.3389/fimmu.2026.1788957

354 views

Original Research

Accepted on 12 Feb 2026

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment

in Vaccines and Molecular Therapeutics

I Seul Park
Ji Hyung Kim
Dongyeop Kim
Ye Won Kim
Yoojin Shin
Ki Beom Kim
Haiying Zhang
TAE IL KIM
Seung Won Kim
Young-guen Kwon

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Biologics for Eosinophilic COPD: Current Applications and Future Prospects

in Vaccines and Molecular Therapeutics

Qi Qi
Wenbei Peng
Bohan Yang
Shijie Liu
Ying Pu
Qiong Zhou

Frontiers in Immunology

Review

Published on 12 Feb 2026

mRNA vaccines transform personalized lung cancer treatment

in Vaccines and Molecular Therapeutics

Kaiqi Wei
Zitong Wan
Miaomiao Wen
Shaowei Xin
Yinxi Zhou
Jun Wei
Jianfei Zhu
Chengbin Tang
Yanlu Xiong
Tao Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707654

1,243 views

Methods

Accepted on 11 Feb 2026

Methodology for a freshly engineered or cryo-preserved 3D tuberculoma bioplatform for studying tuberculosis biology and high-content screening of therapeutics

in Vaccines and Molecular Therapeutics

Suraj B. Sable
Allison Kline
Wen Li
James E Posey

Frontiers in Immunology

Brief Research Report

Accepted on 10 Feb 2026

Clinical Outcomes-Dependent IgG Epitope Profiling in HTLV-1 Reveals Differential Recognition of Pathogen-Derived Antigens

in Vaccines and Molecular Therapeutics

Natali Espasiani Cilento
João Vitor da Silva Borges
Nicolle Rakanidis Machado
Lais Alves do Nascimento
Anna Luisa Baratelli Moreira
Lhays Ozório Passos
Aline Boveto Santamarina
Jorge Casseb
Sabri Saeed Sanabani
Jefferson Russo Victor

Frontiers in Immunology

169 views

Review

Accepted on 09 Feb 2026

Identification of metabolic signatures of immune response following mRNA and inactivated vaccines against COVID-19: a systematic review

in Vaccines and Molecular Therapeutics

Andrzej Wasilewski
Agata Serrafi

Frontiers in Immunology

Original Research

Accepted on 09 Feb 2026

Inhaled Bovine Lactoferrin Modulates the p47phox–MPO–NETosis Axis in Acute Lung Injury: Implications for Bioengineered Nanomedicine in Respiratory Infections

in Vaccines and Molecular Therapeutics

Guoan Xiang
Di Lian
jingchao cao
zhongkuo yu
yaru liu
Xiaoxiang Hu
Shoulong Deng
Xin Li
lixin xie

Frontiers in Immunology

Original Research

Published on 09 Feb 2026

Unlocking binding properties of single-domain antibodies targeting the polymeric immunoglobulin receptor to enhance mucosal enrichment of IgG against respiratory syncytial virus

in Vaccines and Molecular Therapeutics

Jia Liu
Jiwon Jung
Siqun Zhou
Shi-Juan Chen
Jiping Huang
Yinyan Tang
Karin Vroom
Soha Motlagh
Daoyang Chen
Huong Trinh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739562

618 views

Original Research

Published on 09 Feb 2026

Mincle-dependent Th17 adjuvanticity requires TNFR1 signaling in myeloid cells

in Vaccines and Molecular Therapeutics

Robert Blamberg
Carl Haberkamp
Gabriel Kristian Pedersen
Ida Rosenkrands
Ulrike Schleicher
Barbara U. Schraml
Sho Yamasaki
Roland Lang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1746618

571 views

Original Research

Accepted on 06 Feb 2026

Mycobacterium tuberculosis antigen containing-exosomes reinforce BCG vaccine efficacy by augmenting long term protection and memory response against experimental tuberculosis in BALB-C mice

in Vaccines and Molecular Therapeutics

Manu Sharma
Sher Afghan
Amit Singh
M I Alam
Meetu Agarwal
Mohd. Shahid
Shaikh Muhammad Atif
Saif Khan
Syed Saima Malik
Vengala Rao Yenuganti

Frontiers in Immunology

131 views

Original Research

Published on 06 Feb 2026

In silico design of a multiepitope subunit vaccine targeting Salmonella enterica serovar Infantis: an immunoinformatics and reverse vaccinology approach

in Vaccines and Molecular Therapeutics

Dhiraj Chundru
Mostafa Ghanem

Frontiers in Immunology

doi 10.3389/fimmu.2026.1717278

427 views

Perspective

Published on 05 Feb 2026

Is the reverse vaccinology idea becoming exhausted?

in Vaccines and Molecular Therapeutics

Javier Zumárraga
Daniel López
Javier Sotillo
Michael J. McConnell
Antonio J. Martín-Galiano

Frontiers in Immunology

doi 10.3389/fimmu.2026.1730217

667 views

Original Research

Published on 05 Feb 2026

MVA-Spike encoding the A subunit of dmLT safely enhances systemic and mucosal immune responses

in Vaccines and Molecular Therapeutics

Stephan Rambichler
Ronny Kassub
Rodrigo Carrasco-León
Kerstin Lämmermann
Markus Feigl
Barbara Bathke
Clémentine Durand
Živa Fras
Alexander Heiseke
André Riedl

Frontiers in Immunology

doi 10.3389/fimmu.2026.1771410

615 views

Original Research

Published on 05 Feb 2026

Possible role of pre-vaccination T-lymphocyte subpopulations in the antibody response to COVID-19 vaccines in children undergoing chemotherapy

in Vaccines and Molecular Therapeutics

Csaba Péterfia
Zsolt I. Komlósi
Zoltán Pós
Nikolett Lupsa
Nóra Fekete
Katalin Böröcz
Timea Dergez
Evelin A. Leibinger
Noémi Benedek
Ágnes Vojcek

Frontiers in Immunology

doi 10.3389/fimmu.2026.1728845

425 views

Original Research

Accepted on 03 Feb 2026

Treponema pallidum mRNA-LNP vaccine candidate encoding TP0954 induces strongly protective immunity in rabbits

in Vaccines and Molecular Therapeutics

Zhiyu Lu
Yizhou Lu
Di Liu
Fangzhi Du
Qingyun Wu
Guoyang Liao
Yanan Wu
Ruili Zhang
Jian Zhou
Qian-Qiu Wang

Frontiers in Immunology

471 views

Original Research

Accepted on 03 Feb 2026

Broad Innate Immune Activation Enhances the Protective Efficacy of rBCG-LTAK63 Against Mycobacterium tuberculosis

in Vaccines and Molecular Therapeutics

Ana Carolina de Oliveira Carvalho
Monalisa Martins Trentini
Dunia Rodriguez
Lázaro Moreira Marques-Neto
Paulo Henrique Santana Silveira
Nancy Starobinas
Sergio Costa Oliveira
Luciana C C Leite
Alex Kanno

Frontiers in Immunology

113 views

Original Research

Accepted on 03 Feb 2026

Impact of cross-linking stoichiometry on the structure and allergenicity of glutaraldehyde-polymerized allergen extracts

in Vaccines and Molecular Therapeutics

Sandra Sivill
Marcos Viñuela
Diego García-Puentes
Lucia Moreno-Serna
Emilio Nuñez-Borque
Rodrigo Jiménez-Saiz
Maria Vila-Gonzalo
Miguel Fernandez-Arquero
Irene Real-Arévalo
Salvador Iborra

Frontiers in Immunology

137 views

Original Research

Published on 03 Feb 2026

Synergistic immune protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice

in Vaccines and Molecular Therapeutics

Anran Shen
Suyue Zhu
Min Li
Yu Zhao
Yandan Wu
Yue Zhang
Jiejie Zhang
Xuelian Han
Yuan Wang
Guangyu Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1729444

488 views

Review

Published on 03 Feb 2026

Revisiting the streptococcal M protein: modern perspectives on antibody function, host interactions, and therapeutic targeting

in Vaccines and Molecular Therapeutics

Sebastian Wrighton
Pontus Nordenfelt

Frontiers in Immunology

doi 10.3389/fimmu.2026.1771053

685 views

Brief Research Report

Accepted on 02 Feb 2026

Experimental Validation and Immunogenic Insights of Multiepitope Vaccine design against Streptococcus pneumoniae

in Vaccines and Molecular Therapeutics

Yogeshwar Devarakonda
MVN Janardhan Reddy
Arunima Binu
KIRTIMAAN SYAL

Frontiers in Immunology

126 views

Original Research

Accepted on 02 Feb 2026

Immunopeptidomics of cutaneous leishmaniasis patients reveals the natural antigenic landscape

in Vaccines and Molecular Therapeutics

Nicky De Vrij
Elise Pepermans
Louise Laurijssen
Thao-Thy Pham
Lauren Thijs
Kurt Boonen
Kadrie Ramadan
Ilse Maes
Yetemwork Aleka
Mekibib Kassa

Frontiers in Immunology

106 views

3,189 articles

articles

The Role of Large Immune Complexes in Anti-drug Antibody Development: A Case Study of Anti-SARS-CoV-2 Antibody Therapeutics and Co-administered mRNA vaccine

Novel BPI3Vc-vectored surface displayed fusion and hemagglutinin-neuraminidase antigens elicit broadly neutralizing antibodies in cattle

Correction: Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment

Biologics for Eosinophilic COPD: Current Applications and Future Prospects

mRNA vaccines transform personalized lung cancer treatment

Methodology for a freshly engineered or cryo-preserved 3D tuberculoma bioplatform for studying tuberculosis biology and high-content screening of therapeutics

Clinical Outcomes-Dependent IgG Epitope Profiling in HTLV-1 Reveals Differential Recognition of Pathogen-Derived Antigens

Identification of metabolic signatures of immune response following mRNA and inactivated vaccines against COVID-19: a systematic review

Inhaled Bovine Lactoferrin Modulates the p47phox–MPO–NETosis Axis in Acute Lung Injury: Implications for Bioengineered Nanomedicine in Respiratory Infections

Unlocking binding properties of single-domain antibodies targeting the polymeric immunoglobulin receptor to enhance mucosal enrichment of IgG against respiratory syncytial virus

Mincle-dependent Th17 adjuvanticity requires TNFR1 signaling in myeloid cells

Mycobacterium tuberculosis antigen containing-exosomes reinforce BCG vaccine efficacy by augmenting long term protection and memory response against experimental tuberculosis in BALB-C mice

In silico design of a multiepitope subunit vaccine targeting Salmonella enterica serovar Infantis: an immunoinformatics and reverse vaccinology approach

Is the reverse vaccinology idea becoming exhausted?

MVA-Spike encoding the A subunit of dmLT safely enhances systemic and mucosal immune responses

Possible role of pre-vaccination T-lymphocyte subpopulations in the antibody response to COVID-19 vaccines in children undergoing chemotherapy

Treponema pallidum mRNA-LNP vaccine candidate encoding TP0954 induces strongly protective immunity in rabbits

Broad Innate Immune Activation Enhances the Protective Efficacy of rBCG-LTAK63 Against Mycobacterium tuberculosis

Impact of cross-linking stoichiometry on the structure and allergenicity of glutaraldehyde-polymerized allergen extracts

Synergistic immune protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice

Revisiting the streptococcal M protein: modern perspectives on antibody function, host interactions, and therapeutic targeting

Experimental Validation and Immunogenic Insights of Multiepitope Vaccine design against Streptococcus pneumoniae

Immunopeptidomics of cutaneous leishmaniasis patients reveals the natural antigenic landscape