Frontiers in Immunology | Vaccines and Molecular Therapeutics

Review

Published on 19 Sep 2025

Decadal advances and future prospects in subunit vaccine development against Streptococcus suis infection

in Vaccines and Molecular Therapeutics

Lihua Fang
Jie Ning

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680732

558 views

Original Research

Published on 19 Sep 2025

A nanodiamond-formulated plant protein induces robust immunity against porcine epidemic diarrhea virus in piglets

in Vaccines and Molecular Therapeutics

Thuong Thi Ho
Hoai Thu Tran
Phuong Minh Thi Nguyen
Huyen Thi Bui
Hien Thu Thi Nguyen
Thao Bich Thi Le
Minh Dinh Pham
Wesley Wei-Wen Hsiao
Dai Huu Nguyen
Ha Hoang Chu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674222

597 views

Original Research

Published on 19 Sep 2025

Heterologous prime-pull mucosal vaccination with an adjuvanted RBD vaccine elicits robust IgA production and protects against SARS-CoV-2

in Vaccines and Molecular Therapeutics

Allyson H. Hirsch
Calder R. Ellsworth
William A. Lewis
Ryan Craig
Amy E. Meyer
Jonatan Maldonado
Frania Ramirez Lopez
Syamala Rani Thimmiraju
James B. McLachlan
Xuebin Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673460

937 views

Correction

Published on 19 Sep 2025

Correction: Immune response dynamics of SARS-CoV-2 vaccination in chronic lymphocytic leukemia individuals: a descriptive analysis

in Vaccines and Molecular Therapeutics

Clara Sánchez-Menéndez
Alejandro Zurdo
Magdalena Corona
Elena Mateos de la Morenas
Sara Rodríguez-Mora
Guiomar Casado
Javier García-Pérez
Mayte Pérez-Olmeda
Susana Domínguez
María Aránzazu Murciano-Antón

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706723

645 views

Original Research

Accepted on 18 Sep 2025

A biomimetic model composed of injectable 3D-muscle like tissue, stromal and immune cells for recapitulating the rapid immune signature predictive of mRNA vaccine immunogenicity

in Vaccines and Molecular Therapeutics

Marilena Paola Etna
Claudia Fuoco
Martina Severa
Daniela Ricci
Alessandro Sinigaglia
Camilla Lucca
Giada Cairo
Barbara Bottazzi
Cecilia Garlanda
Anna Teresa Palamara

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651095

197 views

Original Research

Published on 18 Sep 2025

Heterologous prime-boost vaccination with VLA2001 and an ORFV-based vector enhances spike- and nucleocapsid-specific immunity in mice

in Vaccines and Molecular Therapeutics

Alena Reguzova
Verena Haug
Carina Metz
Melanie Müller
Madeleine Fandrich
Alex Dulovic
Ralf Amann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675859

904 views

Review

Published on 18 Sep 2025

Controlled human malaria infection studies: insights into recent advances and key immunological and ethical implementation lessons

in Vaccines and Molecular Therapeutics

Rodney Ogwang
Mohamed Adan
Philip Bejon
Melissa C. Kapulu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672945

1,082 views

Original Research

Accepted on 17 Sep 2025

Immunoadjuvanted influenza vaccine immunogenicity in children with type 1 diabetes over two consecutive seasons

in Vaccines and Molecular Therapeutics

Mikhail Petrovich Kostinov
Maria Alexandrovna Kvasova
Alla Anatolievna Tarasova
Anna Vlasenko
Elena Vladimirovna Kolbasina
Darya Alexandrovna Bydanova
ARISTITSA KOSTINOVA
Valentina Polishchuk
Isabella Abramovna Khrapunova
Marina Loktionova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597619

370 views

Review

Accepted on 16 Sep 2025

MAPPs Assays For Non-Clinical Immunogenicity Risk Assessment: Best Practices Recommended By The European Immunogenicity Platform

in Vaccines and Molecular Therapeutics

Anette Christine Karle
Katharina L. Kopp
Robert Joseph Seward
Sophie Tourdot
Chloé Ackaert
Michael Gutknecht
Edward Cloake
Noel Smith
Axel Ducret

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690101

367 views

Original Research

Accepted on 16 Sep 2025

Development of potent HLA-A*02:01-restricted peptide-based cytotoxic T-Cells against SARS-CoV-2 infections in kidney patients

in Vaccines and Molecular Therapeutics

Chih-Chao Chang
Ya Nan Liu
ZHENG XU
Elena-Rodica Vasilescu
Ping Li
Eric K Ho
Muyang Li
Syed A Husain
Govind Bhagat
Sumit Mohan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664371

414 views

Review

Published on 16 Sep 2025

Review of advanced research on swine Actinobacillus pleuropneumoniae vaccine development strategy

in Vaccines and Molecular Therapeutics

Adehanom Baraki Tesfaye
Rui Han
Zhengyu Tao
Liuchao You
Jiayao Zhu
Pengcheng Gao
Lei Fu
Yuefeng Chu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645610

1,182 views

Clinical Trial

Published on 16 Sep 2025

No evidence of MMR induced trained immunity to prevent SARS COV2: results from a multi-centre RCT

in Vaccines and Molecular Therapeutics

Sinead Delany-Moretlwe
Hakim-Moulay Dehbi
Izukanji Sikazwe
George Kyei
Kwadwo Koram
Erik Dubberke
Noluthando Mwelase
Dominic Hague
Linda-Gail Bekker
Linda Yun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588190

858 views

Original Research

Accepted on 15 Sep 2025

Impact of an Aerosolized or Intramuscular Adenovirus Type 5-Vectored COVID-19 Vaccine on Fc-Mediated Immune Effector Functions in a Hybrid Immunity Population

in Vaccines and Molecular Therapeutics

Mingzhi Gan
Chuang Li
Simin Li
Zhuangzhuang Huang
Lingjie Xu
Xiaoyu Xu
Yuxin Chen
Jingxin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657235

347 views

Brief Research Report

Accepted on 15 Sep 2025

SARS-CoV-2 vaccines induce a diverse spike-specific CD4+ T cell receptor repertoire in people living with HIV with low CD4 nadirs

in Vaccines and Molecular Therapeutics

Alicia Mercado
Joel Sop
Steven Amanat
Li Zhang
Natasha M Chida
Christie R Basseth
Kelly Gebo
Annukka Antar
Kellie N Smith
Zhen Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663819

357 views

Opinion

Accepted on 15 Sep 2025

One Hundred Years of BCG: The Journey of Tuberculosis Vaccination in Brazil

in Vaccines and Molecular Therapeutics

Eloise Trostdorf Monteiro Filardi
ROBERTO CARLOS CRUZ CARBONELL
Fernando Rogerio Pavan
Felipe Augusto Cerni
Manuela Berto Pucca

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655969

102 views

Original Research

Published on 15 Sep 2025

Comparative single-cell immune responses in peripheral blood and lymph node of immunized SARS-CoV-2 challenged infant rhesus macaques

in Vaccines and Molecular Therapeutics

Sasha Anronikov
Cameron Meikle
Emma C. Milligan
Han Chen
Nilanjan Mukherjee
Zach Bjornson
Brice Gaudillière
Sizun Jiang
Sallie R. Permar
Koen K. A. Van Rompay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599408

1,549 views