Frontiers in Immunology

Original Research

Published on 11 Feb 2026

A fully human IgG1 antibody targeting MICA α1 domain inhibits interaction with NKG2D and activates immune effector functions against MICA-expressing cells

Ivo Campos
Fabiola González-Herrera
Yuneisy Guerra
María José Garrido
Nicolás Fehring
Carla Diaz
Douglas J. Matthies
Mauricio González
Samantha Tello
Fabián Tempio

Frontiers in Immunology

doi 10.3389/fimmu.2026.1740184

785 views

Original Research

Published on 11 Feb 2026

Metabolic reprogramming of glioma-associated macrophages identifies detoxification and energetic macrophages as drivers of immunosuppression and therapeutic vulnerability

Sujie Gu
Zhonghao Dou
Haoyu Shen
Hongfu Zhang
Yueyang Ba
Jianjun Gu
Peng Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1752553

429 views

Original Research

Published on 11 Feb 2026

Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1α/LSH/SCD1-mediated ferroptosis

Xin Ma
Xin Wang
Daobin Jiang
Yiminnuer Tuerxun
Siming Tao
Fengsen Li
Yanrong Wei
Liu Yang
Lei Xi
Ling Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1760615

551 views

Original Research

Published on 11 Feb 2026

Galectin-1 levels do not predict outcomes in undifferentiated arthritis: a two-year prospective observational study

Cristina Valero-Martínez
Marisa Pardines-Ortiz
Nuria Montes
Ana M. Ortiz
Rosario García-Vicuña
Isidoro González-Alvaro
Ana Triguero-Martínez

Frontiers in Immunology

doi 10.3389/fimmu.2026.1757168

372 views

Opinion

Published on 11 Feb 2026

Beyond cytokine blockade: could CAR-Tregs open a new era of tissue-targeted immune tolerance in psoriatic arthritis?

Rubén Queiro
Sara Alonso
Mercedes Alperi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1772369

481 views

Review

Published on 11 Feb 2026

TRIM proteins as emerging regulators of immune pathways: potential therapeutic targets in immune-related disorders

Bilal Jawed
Rimsha Kanwal
Syed Khuram Zakir
Francesco Gaudio
Jessica Elisabetta Esposito
Azfar Athar Ishaqui
Stefano Martinotti
Matteo Botteghi
Elena Toniato

Frontiers in Immunology

doi 10.3389/fimmu.2026.1764253

281 views

Review

Published on 11 Feb 2026

Single-cell dissection of hepatocellular carcinoma immunity: from heterogeneous subtypes to precision therapeutics

Yuni Liang
Hemeng Wu
Yunshan Qiu
Qiulian Mo
Peipei Chen
Mingfen Li
Hongsheng Lin

Frontiers in Immunology

doi 10.3389/fimmu.2026.1744845

314 views

Systematic Review

Published on 11 Feb 2026

The effects of different exercise interventions on clinical outcomes of irritable bowel syndrome and their potential mechanisms: a systematic review and network meta-analysis

Zheping Quan
Weijia Song
Qianting Huang
Jiale Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1730624

352 views

Original Research

Published on 11 Feb 2026

Characterizing tumor microenvironment heterogeneity in EBV+ nTNKL vs ENKTL using spatial transcriptomics and MIF

Siyu Qian
Zeyuan Wang
Yue Zhang
Wanyue Zhao
Honghan Qiao
Xiaoyan Feng
Yukai Duan
Boyuan Su
Shifeng Hao
Zhenzhen Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1717844

406 views

Review

Published on 11 Feb 2026

Restoring B cell intrinsic tolerance to lupus autoimmunity: a rational strategy for lupus treatment

Shreya Desikan Shai
Sailee Vijay Chavan
Elaine Zi Huan
Peter M. Kalin
Miriam Feuerman
Christopher A. J. Roman
Chongmin Huan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1728403

365 views

Mini Review

Published on 11 Feb 2026

Functional roles and mechanisms of circRNA-protein interactions in cancer progression and tumor immune regulation

Lin Yang
Chunhong Li
Xiulin Jiang
Yixiao Yuan
Chongxin Li
Qiang Zhou
Qiang Wang
Jie Xiong

Frontiers in Immunology

doi 10.3389/fimmu.2026.1771949

218 views

Case Report

Published on 11 Feb 2026

A rare presentation of CASPR2-associated Morvan syndrome overlapping with GM1-positive AMSAN: a case report

Yajing Wu
Xiaoli Tang
Tianyuan Guan
Jing Xu
Peiyuan Lv
Yanhong Dong

Frontiers in Immunology

doi 10.3389/fimmu.2026.1755001

316 views

Case Report

Published on 11 Feb 2026

Case Report: Tricho-hepato-enteric syndrome in an infant presented with colorectal ulceration and severe respiratory superinfection

Yuta Narishige
Tomohiro Nakano
Yusuke Hoshi
Kenji Sonota
Hiroki Sakurai
Fumihiko Kakuta
Taku Koizumi
Yoji Sasahara
Daiki Abukawa

Frontiers in Immunology

doi 10.3389/fimmu.2026.1721204

250 views

Editorial

Published on 11 Feb 2026

Editorial: The transcriptional and metabolic role of Foxp3 in regulatory T cells

Mehdi Benamar

Frontiers in Immunology

doi 10.3389/fimmu.2026.1796661

341 views

Case Report

Published on 11 Feb 2026

Successful tocilizumab-based combination therapy for a case of rapidly progressive adult deep morphea with multiple antiphospholipid antibodies: a case report and literature review

Ruohan Yu
Lina Zhang
Sheng-Guang Li
Jing Zhang
Ji Li
Yadan Zou
Ting Long
Yanfeng Zhang
Guanjun Yue

Frontiers in Immunology

doi 10.3389/fimmu.2026.1764835

311 views

Case Report

Published on 11 Feb 2026

Small B-cell lymphoma highly suspicious for splenic marginal zone lymphoma with MYD88 L265P mutation and MYC copy-number gain presenting as severe autoimmune hemolytic anemia: a case report with literature review

Xiaoyan Liu
Guoyang Zhang
Liping Ma

Frontiers in Immunology

doi 10.3389/fimmu.2026.1767267

218 views

Original Research

Published on 11 Feb 2026

Efficacy and safety of telitacicept combined with immunosuppressive therapy for IgA nephropathy: a retrospective multicenter cohort study

Fang Zeng
Yang Yang
Fei Tan
Yebei Li
Daijin Ren
Chengmin Cai
Jiang Wang
Wenjun Yan
Xiaojie Xie
Yu Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1740891

442 views

Original Research

Published on 11 Feb 2026

An interpretable deep learning framework based on TabNet-Cox for risk stratification and prognostic assessment in hepatocellular carcinoma immunotherapy

Wei Dong
Cheng Qian

Frontiers in Immunology

doi 10.3389/fimmu.2026.1751829

338 views

Review

Published on 11 Feb 2026

The dual roles of exosomes in prostate cancer: mechanisms in tumorigenesis and avenues for clinical translation

Mingyun Yu
Dan Zhou
Huijie Wei
Tong Wu
Jiahong Fan
Guanghe Ran
Chong Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1748272

385 views

Case Report

Published on 11 Feb 2026

Pathological complete response in esophageal squamous cell carcinoma complicated by malignant fistula via neoadjuvant immunotherapy, chemoradiotherapy, and nutritional support: a case report

Nanxi Li
Mei Lan
Wenxiu Yao
Yixiang Zhu
Qifeng Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1750544

294 views

Original Research

Published on 11 Feb 2026

Novel involvement of LMTK2 and EML6 in rheumatoid arthritis: potential biomarkers for disease activity and seronegative patients

Hubert Kubis
Marek Cieśla
Anna Pałka
Bogdan Kolarz

Frontiers in Immunology

doi 10.3389/fimmu.2026.1751440

458 views

Original Research

Published on 11 Feb 2026

Proteomic profiling of circulating extracellular vesicles from COVID-19 patients and their impact on innate Vdelta2 T-cell response

Claudia Montaldo
Eleonora Cimini
Eleonora Tartaglia
Manuela Antonioli
Veronica Bordoni
Stefania Notari
Michela Notarangelo
Eleonora Torchia
Giulia Canarutto
Silvano Piazza

Frontiers in Immunology

doi 10.3389/fimmu.2026.1748398

571 views

Review

Published on 11 Feb 2026

NKG2D CAR-T cells for solid tumor immunotherapy: advances, challenges, and future directions

Chen Liu
Zhiqiang Wang
Wentao Zhang
Guangping Cheng
Siyan Cheng
Long Qin
Huili Ye
Wen Ren

Frontiers in Immunology

doi 10.3389/fimmu.2026.1763843

355 views

Original Research

Published on 11 Feb 2026

Salidroside targets the Notch1/Hes5 axis to reconstruct the molecular innate immune–vascular network and correlates with repair after ischemic stroke

Jing Zeng
Xiaohua Huang
Jingyi Zeng
Qi Huang
Wenyi Song
Youfeng Xie
Guining Liang
Qingyan Wei
Yating Lan
Donghua Zou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1756559

471 views

49,797 Publications

volumes

Volume 17 - 2026

A fully human IgG1 antibody targeting MICA α1 domain inhibits interaction with NKG2D and activates immune effector functions against MICA-expressing cells

Metabolic reprogramming of glioma-associated macrophages identifies detoxification and energetic macrophages as drivers of immunosuppression and therapeutic vulnerability

Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1α/LSH/SCD1-mediated ferroptosis

Galectin-1 levels do not predict outcomes in undifferentiated arthritis: a two-year prospective observational study

Beyond cytokine blockade: could CAR-Tregs open a new era of tissue-targeted immune tolerance in psoriatic arthritis?

TRIM proteins as emerging regulators of immune pathways: potential therapeutic targets in immune-related disorders

Single-cell dissection of hepatocellular carcinoma immunity: from heterogeneous subtypes to precision therapeutics

The effects of different exercise interventions on clinical outcomes of irritable bowel syndrome and their potential mechanisms: a systematic review and network meta-analysis

Characterizing tumor microenvironment heterogeneity in EBV+ nTNKL vs ENKTL using spatial transcriptomics and MIF

Restoring B cell intrinsic tolerance to lupus autoimmunity: a rational strategy for lupus treatment

Functional roles and mechanisms of circRNA-protein interactions in cancer progression and tumor immune regulation

A rare presentation of CASPR2-associated Morvan syndrome overlapping with GM1-positive AMSAN: a case report

Case Report: Tricho-hepato-enteric syndrome in an infant presented with colorectal ulceration and severe respiratory superinfection

Editorial: The transcriptional and metabolic role of Foxp3 in regulatory T cells

Successful tocilizumab-based combination therapy for a case of rapidly progressive adult deep morphea with multiple antiphospholipid antibodies: a case report and literature review

Small B-cell lymphoma highly suspicious for splenic marginal zone lymphoma with MYD88 L265P mutation and MYC copy-number gain presenting as severe autoimmune hemolytic anemia: a case report with literature review

Efficacy and safety of telitacicept combined with immunosuppressive therapy for IgA nephropathy: a retrospective multicenter cohort study

An interpretable deep learning framework based on TabNet-Cox for risk stratification and prognostic assessment in hepatocellular carcinoma immunotherapy

The dual roles of exosomes in prostate cancer: mechanisms in tumorigenesis and avenues for clinical translation

Pathological complete response in esophageal squamous cell carcinoma complicated by malignant fistula via neoadjuvant immunotherapy, chemoradiotherapy, and nutritional support: a case report

Novel involvement of LMTK2 and EML6 in rheumatoid arthritis: potential biomarkers for disease activity and seronegative patients

Proteomic profiling of circulating extracellular vesicles from COVID-19 patients and their impact on innate Vdelta2 T-cell response

NKG2D CAR-T cells for solid tumor immunotherapy: advances, challenges, and future directions

Salidroside targets the Notch1/Hes5 axis to reconstruct the molecular innate immune–vascular network and correlates with repair after ischemic stroke